prikaz prve stranice dokumenta Plasma Brain-Derived Neurotrophic Factor Levels in First-Episode and Recurrent Major Depression and before and after Bright Light Therapy in Treatment-Resistant Depression
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Plasma Brain-Derived Neurotrophic Factor Levels in First-Episode and Recurrent Major Depression and before and after Bright Light Therapy in Treatment-Resistant Depression
Biomolecules, 13 (2023), 9; 1425. https://doi.org/10.3390/biom13091425
Kosanović Rajačić, Biljana; Šagud, Marina; Begić, Dražen; Nikolac Perković, Matea; Dvojković, Anja; Ganoci, Lana; Pivac, Nela

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Kosanović Rajačić, B., Šagud, M., Begić, D., Nikolac Perković, M., Dvojković, A., Ganoci, L. i Pivac, N. (2023). Plasma Brain-Derived Neurotrophic Factor Levels in First-Episode and Recurrent Major Depression and before and after Bright Light Therapy in Treatment-Resistant Depression. Biomolecules, 13. (9). doi: 10.3390/biom13091425

Kosanović Rajačić, Biljana, et al. "Plasma Brain-Derived Neurotrophic Factor Levels in First-Episode and Recurrent Major Depression and before and after Bright Light Therapy in Treatment-Resistant Depression." Biomolecules, vol. 13, br. 9, 2023. https://doi.org/10.3390/biom13091425

Kosanović Rajačić, Biljana, Marina Šagud, Dražen Begić, Matea Nikolac Perković, Anja Dvojković, Lana Ganoci i Nela Pivac. "Plasma Brain-Derived Neurotrophic Factor Levels in First-Episode and Recurrent Major Depression and before and after Bright Light Therapy in Treatment-Resistant Depression." Biomolecules 13, br. 9 (2023). https://doi.org/10.3390/biom13091425

Kosanović Rajačić, B., et al. (2023) 'Plasma Brain-Derived Neurotrophic Factor Levels in First-Episode and Recurrent Major Depression and before and after Bright Light Therapy in Treatment-Resistant Depression', Biomolecules, 13(9). doi: 10.3390/biom13091425

Kosanović Rajačić B, Šagud M, Begić D, Nikolac Perković M, Dvojković A, Ganoci L, i sur.. Plasma Brain-Derived Neurotrophic Factor Levels in First-Episode and Recurrent Major Depression and before and after Bright Light Therapy in Treatment-Resistant Depression. Biomolecules [Internet]. 20.09.2023. [pristupljeno 14.07.2024.];13(9). doi: 10.3390/biom13091425

B. Kosanović Rajačić, et al., "Plasma Brain-Derived Neurotrophic Factor Levels in First-Episode and Recurrent Major Depression and before and after Bright Light Therapy in Treatment-Resistant Depression", Biomolecules, vol. 13, br. 9, Rujan 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:916343. [Citirano: 14.07.2024.]

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Naslov (engleski)Plasma Brain-Derived Neurotrophic Factor Levels in First-Episode and Recurrent Major Depression and before and after Bright Light Therapy in Treatment-Resistant Depression
AutorBiljana Kosanović Rajačić
AutorMarina Šagud
AutorDražen Begić
AutorMatea Nikolac Perković
AutorAnja Dvojković
AutorLana Ganoci
AutorNela Pivac
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PSIHIJATRIJU I PSIHOLOŠKU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Brain-derived neurotrophic factor (BDNF) is implicated in the etiology and treatment response in major depressive disorder (MDD). However, peripheral BDNF concentrations have not been compared across different MDD stages. Bright light therapy (BLT) offers some potential in treatment-resistant depression (TRD), but its effects on BDNF levels are unknown. This study included a cross-sectional analysis of plasma BDNF concentration in females with TRD, unmedicated MDD patients, and healthy controls (HC), and measurements of longitudinal BLT effects on plasma BDNF levels in TRD patients. The present study included 55 drug-naïve, first-episode patients, 25 drug-free recurrent-episode MDD patients, 71 HC participants, and 54 TRD patients. Patients were rated by Hamilton Depression Rating Scale (HAMD)-17 and the Montgomery–Åsberg Depression Rating Scale (MADRS). Patients with TRD received BLT during 4 weeks. The total HAMD-17 and MADRS scores decreased following BLT. All patient groups had lower plasma BDNF than HC, but BDNF levels did not differ between first- and recurrent-episode BDNF patients and TRD patients before or after BLT. However, responders and remitters to BLT had higher post-treatment plasma BDNF concentrations than patients who did not achieve response or remission. The changes in plasma BDNF levels may be candidates for biomarkers of treatment response to BLT in TRD patients.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiomolecules
Brojčani podacivol. 13, br. 9, 1425
e-ISSN2218-273X
DOIhttps://doi.org/10.3390/biom13091425
URN:NBNurn:nbn:hr:105:916343
Datum objave publikacije2023-09-20
ProjektŠifra: IPS-2022-02-2497
Naziv (hrvatski): Cirkulirajuće ekstracelularne vezikule kao prediktori antidepresivnog odgovora: Praćenje mehanizma djelovanja novih terapijskih pristupa u depresiji
Naziv (engleski): Circulating Extracellular Vesicles as Predictors of Antidepressant Response: Monitoring the Mechanism of Novel Therapeutic Approaches in Depression
Kratica: EVroPAR
Voditelj: Matea Nikolac Perković
Pravna nadležnost: Hrvatska
Financijer: Hrvatska zaklada za znanost
Linija financiranja: Slovenian-Croatian Bilateral Projects
URL dokumentahttps://www.mdpi.com/2218-273X/13/9/1425
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-05-21 09:24:42