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Technical Aspects and Clinical Limitations of Sperm DNA Fragmentation Testing in Male Infertility: A Global Survey, Current Guidelines, and Expert Recommendations
The World Journal of Men's Health, 42 (2024), 1; 202-215. https://doi.org/10.5534/wjmh.230076
Agarwal, Ashok; Farkouh, Ala’a; Saleh, Ramadan; Hamoda, Taha Abo-Almagd Abdel-Meguid; Salvio, Gianmaria; Boitrelle, Florence; Harraz, Ahmed M.; Ghayda, Ramy Abou; Kavoussi, Parviz; Gül, Murat; Toprak, Tuncay; Russo, Giorgio Ivan; Durairajanayagam, Damayanthi; Rambhatla, Amarnath; Birowo, Ponco; Cannarella, Rossella; Phuoc, Nguyen Ho Vinh; Zini, Armand; Arafa, Mohamed; Wyns, Christine; Tremellen, Kelton; Sarıkaya, Selçuk; Lewis, Sheena; Evenson, Donald P.; Ko, Edmund; Calogero, Aldo E.; Bahar, Fahmi; Martínez, Marlon; Ambar, Rafael F.; Colpi, Giovanni M.; Bakircioglu, Mustafa Emre; Henkel, Ralf; Kandil, Hussein; Serefoglu, Ege Can; Alfakhri, Abdullah; Tsujimura, Akira; Kheradmand, Alireza; Marino, Angelo; Adamyan, Aram; Zilaitiene, Birute; Ozer, Cevahir; Pescatori, Edoardo; Vogiatzi, Paraskevi; Busetto, Gian Maria; Balercia, Giancarlo; Elbardisi, Haitham; Akhavizadegan, Hamed; Sajadi, Hesamoddin; Taniguchi, Hisanori; Park, Hyun Jun; Maldonado Rosas, Israel; Al-Marhoon, Mohamed; Sadighi Gilani, Mohammad Ali; Alhathal, Naif; Quang, Nguyen; Pinggera, Germar-Michael; Kothari, Priyank; Micic, Sava; Homa, Sheryl; Long, Tran Quang Tien; Zohdy, Wael; Atmoko, Widi; Ibrahim, Wael; Sabbaghian, Marjan; Abumelha, Saad Mohammed; Chung, Eric; Ugur, Muhammet Rasit; Ozkent, Mehmet Serkan; Selim, Osama; Darbandi, Mahsa; Fukuhara, Shinichiro; Jamali, Mounir; de la Rosette, Jean; Kuroda, Shinnosuke; Smith, Ryan P.; Baser, Aykut; Kalkanli, Arif; Tadros, Nicholas N.; Aydos, Kaan; Mierzwa, Tiago Cesar; Khalafalla, Kareim; Malhotra, Vineet; Moussa, Mohamad; Finocchi, Federica; Rachman, Rinaldo Indra; Giulioni, Carlo; Avidor-Reiss, Tomer; Kahraman, Oguzhan; Çeker, Gökhan; Zenoaga-Barbăroşie, Cătălina; Barrett, Trenton L.; Yilmaz, Mehmet; Kadioglu, Ates; Jindal, Sunil; Omran, Huda; Bocu, Kadir; Karthikeyan, Vilvapathy Senguttuvan; Franco, Giorgio; Solorzano, Jesús Fernando; Vishwakarma, Ranjit B.; Arianto, Eko; Garrido, Nicolas; Jain, Divyanu; Gherabi, Nazim; Sokolakis, Ioannis; Palani, Ayad; Calik, Gokhan; Kulaksiz, Deniz; Simanaviciene, Vaida; Simopoulou, Mara; Güngör, Nur Dokuzeylül; Blecher, Gideon; Falcone, Marco; Ježek, Davor; Preto, Mirko; Amar, Edouard; Le, Tan V.; Ahn, Sun Tae; Rezano, Andri; Singh, Keerti; Rocco, Lucia; Savira, Missy; Rajmil, Osvaldo; Darbandi, Sara; Sogutdelen, Emrullah; Boeri, Luca; Hernández, Guadalupe; Hakim, Lukman; Morimoto, Yoshiharu; Japari, Andrian; Sofikitis, Nikolaos; Altay, Baris; Metin Mahmutoglu, Asli; Al Hashimi, Manaf; Ziouziou, Imad; Anagnostopoulou, Christina; Lin, Haocheng; Shah, Rupin Više autora...

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Agarwal, A., Farkouh, A., Saleh, R., Hamoda, T. A. A. A. M., Salvio, G., Boitrelle, F. ... Shah, R. (2024). Technical Aspects and Clinical Limitations of Sperm DNA Fragmentation Testing in Male Infertility: A Global Survey, Current Guidelines, and Expert Recommendations. The World Journal of Men's Health, 42. (1), 202-215. doi: 10.5534/wjmh.230076

Agarwal, Ashok, et al. "Technical Aspects and Clinical Limitations of Sperm DNA Fragmentation Testing in Male Infertility: A Global Survey, Current Guidelines, and Expert Recommendations." The World Journal of Men's Health, vol. 42, br. 1, 2024, str. 202-215. https://doi.org/10.5534/wjmh.230076

Agarwal, Ashok, Ala’a Farkouh, Ramadan Saleh, Taha Abo Almagd Abdel Meguid Hamoda, Gianmaria Salvio, Florence Boitrelle, Ahmed M. Harraz, et al. "Technical Aspects and Clinical Limitations of Sperm DNA Fragmentation Testing in Male Infertility: A Global Survey, Current Guidelines, and Expert Recommendations." The World Journal of Men's Health 42, br. 1 (2024): 202-215. https://doi.org/10.5534/wjmh.230076

Agarwal, A., et al. (2024) 'Technical Aspects and Clinical Limitations of Sperm DNA Fragmentation Testing in Male Infertility: A Global Survey, Current Guidelines, and Expert Recommendations', The World Journal of Men's Health, 42(1), str. 202-215. doi: 10.5534/wjmh.230076

Agarwal A, Farkouh A, Saleh R, Hamoda TAAAM, Salvio G, Boitrelle F, i sur.. Technical Aspects and Clinical Limitations of Sperm DNA Fragmentation Testing in Male Infertility: A Global Survey, Current Guidelines, and Expert Recommendations. The World Journal of Men's Health [Internet]. 01.2024. [pristupljeno 20.12.2024.];42(1):202-215. doi: 10.5534/wjmh.230076

A. Agarwal, et al., "Technical Aspects and Clinical Limitations of Sperm DNA Fragmentation Testing in Male Infertility: A Global Survey, Current Guidelines, and Expert Recommendations", The World Journal of Men's Health, vol. 42, br. 1, str. 202-215, Siječanj 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:077110. [Citirano: 20.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:077110
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Naslov (engleski)Technical Aspects and Clinical Limitations of Sperm DNA Fragmentation Testing in Male Infertility: A Global Survey, Current Guidelines, and Expert Recommendations
AutorAshok Agarwal
AutorAla’a Farkouh
AutorRamadan Saleh
AutorTaha Abo-Almagd Abdel-Meguid Hamoda
AutorGianmaria Salvio
AutorFlorence Boitrelle
AutorAhmed M. Harraz
AutorRamy Abou Ghayda
AutorParviz Kavoussi
AutorMurat Gül
AutorTuncay Toprak
AutorGiorgio Ivan Russo
AutorDamayanthi Durairajanayagam
AutorAmarnath Rambhatla
AutorPonco Birowo
AutorRossella Cannarella
AutorNguyen Ho Vinh Phuoc
AutorArmand Zini
AutorMohamed Arafa
AutorChristine Wyns
AutorKelton Tremellen
AutorSelçuk Sarıkaya
AutorSheena Lewis
AutorDonald P. Evenson
AutorEdmund Ko
AutorAldo E. Calogero
AutorFahmi Bahar
AutorMarlon Martínez
AutorRafael F. Ambar
AutorGiovanni M. Colpi
AutorMustafa Emre Bakircioglu
AutorRalf Henkel
AutorHussein Kandil
AutorEge Can Serefoglu
AutorAbdullah Alfakhri
AutorAkira Tsujimura
AutorAlireza Kheradmand
AutorAngelo Marino
AutorAram Adamyan
AutorBirute Zilaitiene
AutorCevahir Ozer
AutorEdoardo Pescatori
AutorParaskevi Vogiatzi
AutorGian Maria Busetto
AutorGiancarlo Balercia
AutorHaitham Elbardisi
AutorHamed Akhavizadegan
AutorHesamoddin Sajadi
AutorHisanori Taniguchi
AutorHyun Jun Park
AutorIsrael Maldonado Rosas
AutorMohamed Al-Marhoon
AutorMohammad Ali Sadighi Gilani
AutorNaif Alhathal
AutorNguyen Quang
AutorGermar-Michael Pinggera
AutorPriyank Kothari
AutorSava Micic
AutorSheryl Homa
AutorTran Quang Tien Long
AutorWael Zohdy
AutorWidi Atmoko
AutorWael Ibrahim
AutorMarjan Sabbaghian
AutorSaad Mohammed Abumelha
AutorEric Chung
AutorMuhammet Rasit Ugur
AutorMehmet Serkan Ozkent
AutorOsama Selim
AutorMahsa Darbandi
AutorShinichiro Fukuhara
AutorMounir Jamali
AutorJean de la Rosette
AutorShinnosuke Kuroda
AutorRyan P. Smith
AutorAykut Baser
AutorArif Kalkanli
AutorNicholas N. Tadros
AutorKaan Aydos
AutorTiago Cesar Mierzwa
AutorKareim Khalafalla
AutorVineet Malhotra
AutorMohamad Moussa
AutorFederica Finocchi
AutorRinaldo Indra Rachman
AutorCarlo Giulioni
AutorTomer Avidor-Reiss
AutorOguzhan Kahraman
AutorGökhan Çeker
AutorCătălina Zenoaga-Barbăroşie
AutorTrenton L. Barrett
AutorMehmet Yilmaz
AutorAtes Kadioglu
AutorSunil Jindal
AutorHuda Omran
AutorKadir Bocu
AutorVilvapathy Senguttuvan Karthikeyan
AutorGiorgio Franco
AutorJesús Fernando Solorzano
AutorRanjit B. Vishwakarma
AutorEko Arianto
AutorNicolas Garrido
AutorDivyanu Jain
AutorNazim Gherabi
AutorIoannis Sokolakis
AutorAyad Palani
AutorGokhan Calik
AutorDeniz Kulaksiz
AutorVaida Simanaviciene
AutorMara Simopoulou
AutorNur Dokuzeylül Güngör
AutorGideon Blecher
AutorMarco Falcone
AutorDavor Ježek
AutorMirko Preto
AutorEdouard Amar
AutorTan V. Le
AutorSun Tae Ahn
AutorAndri Rezano
AutorKeerti Singh
AutorLucia Rocco
AutorMissy Savira
AutorOsvaldo Rajmil
AutorSara Darbandi
AutorEmrullah Sogutdelen
AutorLuca Boeri
AutorGuadalupe Hernández
AutorLukman Hakim
AutorYoshiharu Morimoto
AutorAndrian Japari
AutorNikolaos Sofikitis
AutorBaris Altay
AutorAsli Metin Mahmutoglu
AutorManaf Al Hashimi
AutorImad Ziouziou
AutorChristina Anagnostopoulou
AutorHaocheng Lin
AutorRupin Shah
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA HISTOLOGIJU I EMBRIOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Citologija, histologija i embriologija
Sažetak (engleski)
Purpose: Sperm DNA fragmentation (SDF) is a functional sperm abnormality that can impact reproductive potential, for which four assays have been described in the recently published sixth edition of the WHO laboratory manual for the examination and processing of human semen. The purpose of this study was to examine the global practices related to the use of SDF assays and investigate the barriers and limitations that clinicians face in incorporating these tests into their practice. Materials and methods: Clinicians managing male infertility were invited to complete an online survey on practices related to SDF diagnostic and treatment approaches. Their responses related to the technical aspects of SDF testing, current professional society guidelines, and the literature were used to generate expert recommendations via the Delphi method. Finally, challenges related to SDF that the clinicians encounter in their daily practice were captured. Results: The survey was completed by 436 reproductive clinicians. Overall, terminal deoxynucleotidyl transferase deoxyuridine triphosphate Nick-End Labeling (TUNEL) is the most commonly used assay chosen by 28.6%, followed by the sperm chromatin structure assay (24.1%), and the sperm chromatin dispersion (19.1%). The choice of the assay was largely influenced by availability (70% of respondents). A threshold of 30% was the most selected cut-off value for elevated SDF by 33.7% of clinicians. Of respondents, 53.6% recommend SDF testing after 3 to 5 days of abstinence. Although 75.3% believe SDF testing can provide an explanation for many unknown causes of infertility, the main limiting factors selected by respondents are a lack of professional society guideline recommendations (62.7%) and an absence of globally accepted references for SDF interpretation (50.3%). Conclusions: This study represents the largest global survey on the technical aspects of SDF testing as well as the barriers encountered by clinicians. Unified global recommendations regarding clinician implementation and standard laboratory interpretation of SDF testing are crucial.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeStručni rad - Stručni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaThe World Journal of Men's Health
Brojčani podacivol. 42, br. 1, str. 202-215
p-ISSN2287-4208
e-ISSN2287-4690
DOIhttps://doi.org/10.5534/wjmh.230076
URN:NBNurn:nbn:hr:105:077110
Datum objave publikacije2024-01
URL dokumentahttps://wjmh.org/DOIx.php?id=10.5534/wjmh.230076
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno 4.0 međunarodna (CC BY-NC 4.0)
Datum i vrijeme pohrane2024-08-19 08:11:35