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Incidence, Risk Factors and Mortality Associated with Major Bleeding Events in Hospitalized COVID-19 Patients
Life, 13 (2023), 8; 1699. https://doi.org/10.3390/life13081699
Lucijanić, Marko; Tješić-Drinković, Ida; Piskač Živković, Nevenka; Paštrović, Frane; Rob, Zrinka; Bačevac, Mersiha; Sedinić Lacko, Martina; Džambas, Eleonora; Medić, Barbara; Vukoja, Ivan; Bušić, Iva; Grgurević, Ivica; Lukšić, Ivica; Baršić, Bruno

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Lucijanić, M., Tješić Drinković, I., Piskač Živković, N., Paštrović, F., Rob, Z., Bačevac, M. ... Baršić, B. (2023). Incidence, Risk Factors and Mortality Associated with Major Bleeding Events in Hospitalized COVID-19 Patients. Life, 13. (8). doi: 10.3390/life13081699

Lucijanić, Marko, et al. "Incidence, Risk Factors and Mortality Associated with Major Bleeding Events in Hospitalized COVID-19 Patients." Life, vol. 13, br. 8, 2023. https://doi.org/10.3390/life13081699

Lucijanić, Marko, Ida Tješić Drinković, Nevenka Piskač Živković, Frane Paštrović, Zrinka Rob, Mersiha Bačevac, Martina Sedinić Lacko, et al. "Incidence, Risk Factors and Mortality Associated with Major Bleeding Events in Hospitalized COVID-19 Patients." Life 13, br. 8 (2023). https://doi.org/10.3390/life13081699

Lucijanić, M., et al. (2023) 'Incidence, Risk Factors and Mortality Associated with Major Bleeding Events in Hospitalized COVID-19 Patients', Life, 13(8). doi: 10.3390/life13081699

Lucijanić M, Tješić Drinković I, Piskač Živković N, Paštrović F, Rob Z, Bačevac M, i sur.. Incidence, Risk Factors and Mortality Associated with Major Bleeding Events in Hospitalized COVID-19 Patients. Life [Internet]. 07.08.2023. [pristupljeno 17.10.2024.];13(8). doi: 10.3390/life13081699

M. Lucijanić, et al., "Incidence, Risk Factors and Mortality Associated with Major Bleeding Events in Hospitalized COVID-19 Patients", Life, vol. 13, br. 8, Kolovoz 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:675492. [Citirano: 17.10.2024.]

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Podaci o radu
Naslov (engleski)Incidence, Risk Factors and Mortality Associated with Major Bleeding Events in Hospitalized COVID-19 Patients
AutorMarko Lucijanić
AutorIda Tješić-Drinković
AutorNevenka Piskač Živković
AutorFrane Paštrović
AutorZrinka Rob
AutorMersiha Bačevac
AutorMartina Sedinić Lacko
AutorEleonora Džambas
AutorBarbara Medić
AutorIvan Vukoja
AutorIva Bušić
AutorIvica Grgurević
AutorIvica Lukšić
AutorBruno Baršić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA KIRURGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Kirurgija
Sažetak (engleski)
Thromboprophylaxis is a mainstay of treatment of hospitalized COVID-19 patients, due to the high occurrence of thrombotic events. This increases the risk of bleeding. However, data on bleeding events and associated risk factors are scarce. Thus, we aimed to investigate the incidence, predictors and clinical outcomes associated with major bleeding in hospitalized COVID-19 patients. We retrospectively evaluated a cohort of 4014 consecutively hospitalized COVID-19 patients treated in a tertiary-level institution in the period 3/2020–3/2021. Bleeding of any kind was documented in 322 (8%) and major bleeding in 129 (3.2%) patients. A total of 129 (40.1%) bleeding events were present at the time of hospital admission, and 193 (59.9%) occurred during hospitalization. In the multivariate logistic regression analysis, intensive-care-unit treatment (adjusted odds ratio (aOR) 6.55; p < 0.001), atrial fibrillation (aOR 2.55; p = 0.029), higher white-blood-cell count (WBC) (aOR 1.03; p = 0.021), lower hemoglobin (aOR 0.97; p = 0.002) and history of bleeding (aOR 17.39; p < 0.001) were recognized as mutually independent predictors of major bleeding. Major bleeding was significantly associated with increased in-hospital mortality compared to non-major-bleeding patients (59.7% vs. 34.8%, p < 0.001), especially if occurring during hospitalization. Median time from major bleeding to death was 5 days. Bleeding events are frequent in hospitalized COVID-19 patients, with a significant proportion of patients presenting at the time of hospital admission, and others almost universally exposed to anticoagulant and corticosteroid therapies. Major bleeding is associated with high mortality, especially if occurring during hospitalization. The recognition of patients at risk and implementation of timely interventions are of high clinical importance.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaLife
Brojčani podacivol. 13, br. 8, 1699
e-ISSN2075-1729
DOIhttps://doi.org/10.3390/life13081699
URN:NBNurn:nbn:hr:105:675492
Datum objave publikacije2023-08-07
URL dokumentahttps://www.mdpi.com/2075-1729/13/8/1699
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-08-19 08:53:36