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Genome-Wide Expression Profile in People with Optic Neuritis Associated with Multiple Sclerosis
Biomedicines, 11 (2023), 8; 2209. https://doi.org/10.3390/biomedicines11082209
Habek, Mario; Blažeković, Antonela; Gotovac Jerčić, Kristina; Pivac, Nela; Outero, Tiago Fleming; Borovečki, Fran; Brinar, Vesna

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Habek, M., Blažeković, A., Gotovac Jerčić, K., Pivac, N., Outero, T. F., Borovečki, F. i Brinar, V. (2023). Genome-Wide Expression Profile in People with Optic Neuritis Associated with Multiple Sclerosis. Biomedicines, 11. (8). doi: 10.3390/biomedicines11082209

Habek, Mario, et al. "Genome-Wide Expression Profile in People with Optic Neuritis Associated with Multiple Sclerosis." Biomedicines, vol. 11, br. 8, 2023. https://doi.org/10.3390/biomedicines11082209

Habek, Mario, Antonela Blažeković, Kristina Gotovac Jerčić, Nela Pivac, Tiago Fleming Outero, Fran Borovečki i Vesna Brinar. "Genome-Wide Expression Profile in People with Optic Neuritis Associated with Multiple Sclerosis." Biomedicines 11, br. 8 (2023). https://doi.org/10.3390/biomedicines11082209

Habek, M., et al. (2023) 'Genome-Wide Expression Profile in People with Optic Neuritis Associated with Multiple Sclerosis', Biomedicines, 11(8). doi: 10.3390/biomedicines11082209

Habek M, Blažeković A, Gotovac Jerčić K, Pivac N, Outero TF, Borovečki F, i sur.. Genome-Wide Expression Profile in People with Optic Neuritis Associated with Multiple Sclerosis. Biomedicines [Internet]. 07.08.2023. [pristupljeno 21.10.2024.];11(8). doi: 10.3390/biomedicines11082209

M. Habek, et al., "Genome-Wide Expression Profile in People with Optic Neuritis Associated with Multiple Sclerosis", Biomedicines, vol. 11, br. 8, Kolovoz 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:519912. [Citirano: 21.10.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:519912
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Podaci o radu
Naslov (engleski)Genome-Wide Expression Profile in People with Optic Neuritis Associated with Multiple Sclerosis
AutorMario Habek
AutorAntonela Blažeković
AutorKristina Gotovac Jerčić
AutorNela Pivac
AutorTiago Fleming Outero
AutorFran Borovečki
AutorVesna Brinar
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA NEUROLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Neurologija
Sažetak (engleski)
The aim of this study was to perform a genome-wide expression analysis of whole-blood samples from people with optic neuritis (ON) and to determine differentially expressed mRNAs compared to healthy control subjects. The study included eight people with acute ON and six healthy control subjects. Gene expression was analyzed using DNA microarrays for whole-human-genome analysis, which contain 54,675 25-base pairs. The additional biostatistical analysis included gene ontology analysis and gene set enrichment analysis (GSEA). Quantitative RT-PCR (qPCR) was used to confirm selected differentially expressed genes. In total, 722 differently expressed genes were identified, with 377 exhibiting increased, and 345 decreased, expression. Gene ontology analysis and GSEA revealed that protein phosphorylation and intracellular compartment, apoptosis inhibition, pathways involved in cell cycles, T and B cell functions, and anti-inflammatory central nervous system (CNS) pathways are implicated in ON pathology. qPCR confirmed the differential expression of eight selected genes, with SLPI, CR3, and ITGA4 exhibiting statistically significant results. In conclusion, whole-blood gene expression analysis showed significant differences in the expression profiles of people with ON compared to healthy control subjects. Additionally, pathways involved in T cell regulation and anti-inflammatory pathways within CNS were identified as important in the early phases of MS.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiomedicines
Brojčani podacivol. 11, br. 8, 2209
e-ISSN2227-9059
DOIhttps://doi.org/10.3390/biomedicines11082209
URN:NBNurn:nbn:hr:105:519912
Datum objave publikacije2023-08-07
URL dokumentahttps://www.mdpi.com/2227-9059/11/8/2209
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-08-20 10:04:39