prikaz prve stranice dokumenta HPV16 Impacts NHERF2 Expression in Oropharyngeal Cancers
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HPV16 Impacts NHERF2 Expression in Oropharyngeal Cancers
Pathogens, 12 (2023), 8; 1013. https://doi.org/10.3390/pathogens12081013
Lulić, Lucija; Jakovčević, Antonia; Kovačić, Iva; Manojlović, Luka; Dediol, Emil; Skelin, Josipa; Tomaić, Vjekoslav

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Lulić, L., Jakovčević, A., Kovačić, I., Manojlović, L., Dediol, E., Skelin, J. i Tomaić, V. (2023). HPV16 Impacts NHERF2 Expression in Oropharyngeal Cancers. Pathogens, 12. (8). doi: 10.3390/pathogens12081013

Lulić, Lucija, et al. "HPV16 Impacts NHERF2 Expression in Oropharyngeal Cancers." Pathogens, vol. 12, br. 8, 2023. https://doi.org/10.3390/pathogens12081013

Lulić, Lucija, Antonia Jakovčević, Iva Kovačić, Luka Manojlović, Emil Dediol, Josipa Skelin i Vjekoslav Tomaić. "HPV16 Impacts NHERF2 Expression in Oropharyngeal Cancers." Pathogens 12, br. 8 (2023). https://doi.org/10.3390/pathogens12081013

Lulić, L., et al. (2023) 'HPV16 Impacts NHERF2 Expression in Oropharyngeal Cancers', Pathogens, 12(8). doi: 10.3390/pathogens12081013

Lulić L, Jakovčević A, Kovačić I, Manojlović L, Dediol E, Skelin J, i sur.. HPV16 Impacts NHERF2 Expression in Oropharyngeal Cancers. Pathogens [Internet]. 03.08.2023. [pristupljeno 09.11.2024.];12(8). doi: 10.3390/pathogens12081013

L. Lulić, et al., "HPV16 Impacts NHERF2 Expression in Oropharyngeal Cancers", Pathogens, vol. 12, br. 8, Kolovoz 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:949477. [Citirano: 09.11.2024.]

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Naslov (engleski)HPV16 Impacts NHERF2 Expression in Oropharyngeal Cancers
AutorLucija Lulić
AutorAntonia Jakovčević
AutorIva Kovačić
AutorLuka Manojlović
AutorEmil Dediol
AutorJosipa Skelin
AutorVjekoslav Tomaić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA KIRURGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Kirurgija
Sažetak (engleski)
Infection with human papillomaviruses (HPVs), in particular with HPV type 16, is now considered to be a key risk factor for the development of a subset of oropharyngeal squamous cell carcinomas (OPSCC) that show different epidemiological, clinical, and prognostic characteristics from HPV-negative (HPV−) OPSCCs. So far, extensive research efforts aiming to distinguish these two distinct entities have not identified specific biomarkers, nor led to different therapies. Previous research has shown that HPV16 E6 oncoprotein binds NHERF2, inducing its proteasomal degradation, and consequently increasing cell proliferation; we therefore aimed to investigate how this might be reflected in human histological samples. We analyzed NHERF2 expression patterns in HPV16-positive (HPV16+) and HPV− OPSCC samples, to investigate any potential differences in NHERF2 pattern. Interestingly, we observed a statistically significant decrease in NHERF2 levels in HPV16+ and poorly differentiated HPV− OPSCCs, compared with healthy tissue. Furthermore, we observed a significant reduction in the percentage of NHERF2 immunoreactive cancer cells in HPV16+ tumors, compared with well and moderately differentiated HPV− OPSCCs, suggesting the importance of 16E6’s targeting of NHERF2 in HPV-driven oncogenesis in the head and neck area.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPathogens
Brojčani podacivol. 12, br. 8, 1013
e-ISSN2076-0817
DOIhttps://doi.org/10.3390/pathogens12081013
URN:NBNurn:nbn:hr:105:949477
Datum objave publikacije2023-08-03
URL dokumentahttps://www.mdpi.com/2076-0817/12/8/1013
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-08-20 10:19:14