Calcium-Sensing Receptor Expression in Breast Cancer

Znanstveni rad - Izvorni znanstveni rad

• Autor: Iva Bušić-Pavlek
• Autor: Ivo Dumić-Čule
• Autor: Lucija Kovačević
• Autor: Milan Milošević
• Autor: Petra Delimar
• Autor: Lea Korša
• Autor: Zlatko Marušić
• Autor: Maja Prutki
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet; (KATEDRA ZA INTERNU MEDICINU)
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet; (KATEDRA ZA RADIOLOGIJU)
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet; (KATEDRA ZA ZDRAVSTVENU EKOLOGIJU, MEDICINU RADA I SPORTA)
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Javno zdravstvo i zdravstvena zaštita; Medicina rada i športa
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Kliničke medicinske znanosti; Radiologija
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Kliničke medicinske znanosti; Interna medicina

Sažetak (engleski)

The calcium-sensing receptor (CaSR) plays a crucial role in maintaining the balance of calcium in the body. Altered signaling through the CaSR has been linked to the development of various tumors, such as colorectal and breast tumors. This retrospective study enrolled 79 patients who underwent surgical removal of invasive breast carcinoma of no special type (NST) to explore the expression of the CaSR in breast cancer. The patients were categorized based on age, tumor size, hormone receptor status, HER2 status, Ki-67 proliferation index, tumor grade, and TNM staging. Immunohistochemistry was conducted on core needle biopsy samples to assess CaSR expression. The results revealed a positive correlation between CaSR expression and tumor size, regardless of the tumor surrogate subtype (p = 0.001). The expression of ER exhibited a negative correlation with CaSR expression (p = 0.033). In contrast, a positive correlation was observed between CaSR expression and the presence of HER2 receptors (p = 0.002). Increased CaSR expression was significantly associated with lymph node involvement and the presence of distant metastasis (p = 0.001 and p = 0.038, respectively). CaSR values were significantly higher in the patients with increased Ki-67 (p = 0.042). Collectively, higher CaSR expression in breast cancer could suggest a poor prognosis and treatment outcome regardless of the breast cancer subtype.

• Ključne riječi (engleski): Biomarkers, Tumor / metabolism; Breast Neoplasms / metabolism; Female; Humans; Ki-67 Antigen / genetics; Ki-67 Antigen / metabolism; Receptor, ErbB-2 / metabolism; Receptors, Calcium-Sensing / genetics; Receptors, Progesterone / metabolism; Retrospective Studies
• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Izvorni znanstveni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: International Journal of Molecular Sciences
• Brojčani podaci: vol. 24, br. 14, 11678
• e-ISSN: 1422-0067
• DOI: https://doi.org/10.3390/ijms241411678
• URN:NBN: urn:nbn:hr:105:873075
• Datum objave publikacije: 2023-07-20
• Projekt: Šifra: IP-2019-04-3684; Naziv (hrvatski): Biomedicinsko oslikavanje karcinoma dojke; Naziv (engleski): Biomedical imaging of breast carcinoma; Kratica: BOBCAt; Voditelj: Maja Prutki; Pravna nadležnost: Hrvatska; Financijer: Hrvatska zaklada za znanost; Linija financiranja: Research Projects
• URL dokumenta: https://www.mdpi.com/1422-0067/24/14/11678
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2024-09-04 11:46:08