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Genotypic and Haplotypic Association of Catechol-O-Methyltransferase rs4680 and rs4818 Gene Polymorphisms with Particular Clinical Symptoms in Schizophrenia
Genes, 14 (2023), 7; 1358. https://doi.org/10.3390/genes14071358
Šagud, Marina; Tudor, Lucija; Nedić Erjavec, Gordana; Nikolac Perkovič, Matea; Uzun, Suzana; Mimica, Ninoslav; Madžarac, Zoran; Živkovic, Maja; Kozumplik, Oliver; Konjevod, Marcela; Švob Štrac, Dubravka; Pivac, Nela

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Šagud, M., Tudor, L., Nedić Erjavec, G., Nikolac Perkovič, M., Uzun, S., Mimica, N. ... Pivac, N. (2023). Genotypic and Haplotypic Association of Catechol-O-Methyltransferase rs4680 and rs4818 Gene Polymorphisms with Particular Clinical Symptoms in Schizophrenia. Genes, 14. (7). doi: 10.3390/genes14071358

Šagud, Marina, et al. "Genotypic and Haplotypic Association of Catechol-O-Methyltransferase rs4680 and rs4818 Gene Polymorphisms with Particular Clinical Symptoms in Schizophrenia." Genes, vol. 14, br. 7, 2023. https://doi.org/10.3390/genes14071358

Šagud, Marina, Lucija Tudor, Gordana Nedić Erjavec, Matea Nikolac Perkovič, Suzana Uzun, Ninoslav Mimica, Zoran Madžarac, et al. "Genotypic and Haplotypic Association of Catechol-O-Methyltransferase rs4680 and rs4818 Gene Polymorphisms with Particular Clinical Symptoms in Schizophrenia." Genes 14, br. 7 (2023). https://doi.org/10.3390/genes14071358

Šagud, M., et al. (2023) 'Genotypic and Haplotypic Association of Catechol-O-Methyltransferase rs4680 and rs4818 Gene Polymorphisms with Particular Clinical Symptoms in Schizophrenia', Genes, 14(7). doi: 10.3390/genes14071358

Šagud M, Tudor L, Nedić Erjavec G, Nikolac Perkovič M, Uzun S, Mimica N, i sur.. Genotypic and Haplotypic Association of Catechol-O-Methyltransferase rs4680 and rs4818 Gene Polymorphisms with Particular Clinical Symptoms in Schizophrenia. Genes [Internet]. 27.06.2023. [pristupljeno 20.12.2024.];14(7). doi: 10.3390/genes14071358

M. Šagud, et al., "Genotypic and Haplotypic Association of Catechol-O-Methyltransferase rs4680 and rs4818 Gene Polymorphisms with Particular Clinical Symptoms in Schizophrenia", Genes, vol. 14, br. 7, Lipanj 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:567260. [Citirano: 20.12.2024.]

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Podaci o radu
Naslov (engleski)Genotypic and Haplotypic Association of Catechol-O-Methyltransferase rs4680 and rs4818 Gene Polymorphisms with Particular Clinical Symptoms in Schizophrenia
AutorMarina Šagud
AutorLucija Tudor
AutorGordana Nedić Erjavec
AutorMatea Nikolac Perkovič
AutorSuzana Uzun
AutorNinoslav Mimica
AutorZoran Madžarac
AutorMaja Živkovic
AutorOliver Kozumplik
AutorMarcela Konjevod
AutorDubravka Švob Štrac
AutorNela Pivac
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PSIHIJATRIJU I PSIHOLOŠKU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Psihijatrija
Sažetak (engleski)
Catechol-O-methyl transferase (COMT) gene variants are involved in different neuropsychiatric disorders and cognitive impairments, associated with altered dopamine function. This study investigated the genotypic and haplotypic association of COMT rs4680 and rs4618 polymorphisms with the severity of cognitive and other clinical symptoms in 544 male and 385 female subjects with schizophrenia. COMT rs4818 G carriers were more frequent in male patients with mild abstract thinking difficulties, compared to CC homozygotes or C allele carriers. Male carriers of COMT rs4680 A allele had worse abstract thinking (N5) scores than GG carriers, whereas AA homozygotes were more frequent in male subjects with lower scores on the intensity of the somatic concern (G1) item, compared to G carriers. Male carriers of COMT rs4818–rs4680 GA haplotype had the highest scores on the G1 item (somatic concern), whereas GG haplotype carriers had the lowest scores on G2 (anxiety) and G6 (depression) items. COMT GG haplotype was less frequent in female patients with severe disturbance of volition (G13 item) compared to the group with mild symptoms, while CG haplotype was more frequent in female patients with severe then mild symptoms. These findings suggest the sex-specific genotypic and haplotypic association of COMT variants with a severity of cognitive and other clinical symptoms of schizophrenia.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaGenes
Brojčani podacivol. 14, br. 7, 1358
e-ISSN2073-4425
DOIhttps://doi.org/10.3390/genes14071358
URN:NBNurn:nbn:hr:105:567260
Datum objave publikacije2023-06-27
URL dokumentahttps://www.mdpi.com/2073-4425/14/7/1358
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-09-05 07:29:44