prikaz prve stranice dokumenta Relationship Between Azithromycin and Cardiovascular Outcomes in Unvaccinated Patients With COVID‐19 and Preexisting Cardiovascular Disease
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Relationship Between Azithromycin and Cardiovascular Outcomes in Unvaccinated Patients With COVID‐19 and Preexisting Cardiovascular Disease
Journal of the American Heart Association, 12 (2023), 14; e028939. https://doi.org/10.1161/JAHA.122.028939
Bergami, Maria; Manfrini, Olivia; Nava, Stefano; Caramori, Gaetano; Yoon, Jinsung; Badimon, Lina; Cenko, Edina; David, Antonio; Demiri, Ilir; Dorobantu, Maria; Fabin, Natalia; Gheorghe‐Fronea, Oana; Jankovic, Radmilo; Kedev, Sasko; Ladjevic, Nebojsa; Lasica, Ratko; Loncar, Goran; Mancuso, Giuseppe; Mendieta, Guiomar; Miličić, Davor; Mjehović, Petra; Pašalić, Marijan; Petrović, Milovan; Poposka, Lidija; Scarpone, Marialuisa; Stefanovic, Milena; van der Schaar, Mihaela; Vasiljevic, Zorana; Vavlukis, Marija; Vega Pittao, Maria Laura; Vukomanovic, Vladan; Zdravkovic, Marija; Bugiardini, Raffaele Više autora...

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Bergami, M., Manfrini, O., Nava, S., Caramori, G., Yoon, J., Badimon, L. ... Bugiardini, R. (2023). Relationship Between Azithromycin and Cardiovascular Outcomes in Unvaccinated Patients With COVID‐19 and Preexisting Cardiovascular Disease. Journal of the American Heart Association, 12. (14). doi: 10.1161/JAHA.122.028939

Bergami, Maria, et al. "Relationship Between Azithromycin and Cardiovascular Outcomes in Unvaccinated Patients With COVID‐19 and Preexisting Cardiovascular Disease." Journal of the American Heart Association, vol. 12, br. 14, 2023. https://doi.org/10.1161/JAHA.122.028939

Bergami, Maria, Olivia Manfrini, Stefano Nava, Gaetano Caramori, Jinsung Yoon, Lina Badimon, Edina Cenko, et al. "Relationship Between Azithromycin and Cardiovascular Outcomes in Unvaccinated Patients With COVID‐19 and Preexisting Cardiovascular Disease." Journal of the American Heart Association 12, br. 14 (2023). https://doi.org/10.1161/JAHA.122.028939

Bergami, M., et al. (2023) 'Relationship Between Azithromycin and Cardiovascular Outcomes in Unvaccinated Patients With COVID‐19 and Preexisting Cardiovascular Disease', Journal of the American Heart Association, 12(14). doi: 10.1161/JAHA.122.028939

Bergami M, Manfrini O, Nava S, Caramori G, Yoon J, Badimon L, i sur.. Relationship Between Azithromycin and Cardiovascular Outcomes in Unvaccinated Patients With COVID‐19 and Preexisting Cardiovascular Disease. Journal of the American Heart Association [Internet]. 18.07.2023. [pristupljeno 19.12.2024.];12(14). doi: 10.1161/JAHA.122.028939

M. Bergami, et al., "Relationship Between Azithromycin and Cardiovascular Outcomes in Unvaccinated Patients With COVID‐19 and Preexisting Cardiovascular Disease", Journal of the American Heart Association, vol. 12, br. 14, Srpanj 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:359470. [Citirano: 19.12.2024.]

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Podaci o radu
Naslov (engleski)Relationship Between Azithromycin and Cardiovascular Outcomes in Unvaccinated Patients With COVID‐19 and Preexisting Cardiovascular Disease
AutorMaria Bergami
AutorOlivia Manfrini
AutorStefano Nava
AutorGaetano Caramori
AutorJinsung Yoon
AutorLina Badimon
AutorEdina Cenko
AutorAntonio David
AutorIlir Demiri
AutorMaria Dorobantu
AutorNatalia Fabin
AutorOana Gheorghe‐Fronea
AutorRadmilo Jankovic
AutorSasko Kedev
AutorNebojsa Ladjevic
AutorRatko Lasica
AutorGoran Loncar
AutorGiuseppe Mancuso
AutorGuiomar Mendieta
AutorDavor Miličić
AutorPetra Mjehović
AutorMarijan Pašalić
AutorMilovan Petrović
AutorLidija Poposka
AutorMarialuisa Scarpone
AutorMilena Stefanovic
AutorMihaela van der Schaar
AutorZorana Vasiljevic
AutorMarija Vavlukis
AutorMaria Laura Vega Pittao
AutorVladan Vukomanovic
AutorMarija Zdravkovic
AutorRaffaele Bugiardini
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Background Empiric antimicrobial therapy with azithromycin is highly used in patients admitted to the hospital with COVID-19, despite prior research suggesting that azithromycin may be associated with increased risk of cardiovascular events. Methods and Results This study was conducted using data from the ISACS-COVID-19 (International Survey of Acute Coronavirus Syndromes-COVID-19) registry. Patients with a confirmed diagnosis of SARS-CoV-2 infection were eligible for inclusion. The study included 793 patients exposed to azithromycin within 24 hours from hospital admission and 2141 patients who received only standard care. The primary exposure was cardiovascular disease (CVD). Main outcome measures were 30-day mortality and acute heart failure (AHF). Among 2934 patients, 1066 (36.4%) had preexisting CVD. A total of 617 (21.0%) died, and 253 (8.6%) had AHF. Azithromycin therapy was consistently associated with an increased risk of AHF in patients with preexisting CVD (risk ratio [RR], 1.48 [95% CI, 1.06-2.06]). Receiving azithromycin versus standard care was not significantly associated with death (RR, 0.94 [95% CI, 0.69-1.28]). By contrast, we found significantly reduced odds of death (RR, 0.57 [95% CI, 0.42-0.79]) and no significant increase in AHF (RR, 1.23 [95% CI, 0.75-2.04]) in patients without prior CVD. The relative risks of death from the 2 subgroups were significantly different from each other (Pinteraction=0.01). Statistically significant association was observed between AHF and death (odds ratio, 2.28 [95% CI, 1.34-3.90]). Conclusions These findings suggest that azithromycin use in patients with COVID-19 and prior history of CVD is significantly associated with an increased risk of AHF and all-cause 30-day mortality.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of the American Heart Association
Brojčani podacivol. 12, br. 14, e028939
e-ISSN2047-9980
DOIhttps://doi.org/10.1161/JAHA.122.028939
URN:NBNurn:nbn:hr:105:359470
Datum objave publikacije2023-07-18
URL dokumentahttps://www.ahajournals.org/doi/10.1161/JAHA.122.028939
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno 4.0 međunarodna (CC BY-NC 4.0)
Datum i vrijeme pohrane2024-09-25 12:27:19