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The Challenges and Opportunities of the Implementation of Comprehensive Genomic Profiling in Everyday Clinical Practice with Non-Small Cell Lung Cancer: National Results from Croatia
Cancers, 15 (2023), 13; 3395. https://doi.org/10.3390/cancers15133395
Čerina, Dora; Krpina, Kristina; Jakopović, Marko; Dedić Plavetić, Natalija; Seiwerth, Fran; Tomić, Snježana; Radić, Jasna; Belac Lovasić, Ingrid; Canjko, Ivana; Boban, Marijo; Samaržija, Miroslav; Vrdoljak, Eduard

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Čerina, D., Krpina, K., Jakopović, M., Dedić Plavetić, N., Seiwerth, F., Tomić, S. ... Vrdoljak, E. (2023). The Challenges and Opportunities of the Implementation of Comprehensive Genomic Profiling in Everyday Clinical Practice with Non-Small Cell Lung Cancer: National Results from Croatia. Cancers, 15. (13). doi: 10.3390/cancers15133395

Čerina, Dora, et al. "The Challenges and Opportunities of the Implementation of Comprehensive Genomic Profiling in Everyday Clinical Practice with Non-Small Cell Lung Cancer: National Results from Croatia." Cancers, vol. 15, br. 13, 2023. https://doi.org/10.3390/cancers15133395

Čerina, Dora, Kristina Krpina, Marko Jakopović, Natalija Dedić Plavetić, Fran Seiwerth, Snježana Tomić, Jasna Radić, et al. "The Challenges and Opportunities of the Implementation of Comprehensive Genomic Profiling in Everyday Clinical Practice with Non-Small Cell Lung Cancer: National Results from Croatia." Cancers 15, br. 13 (2023). https://doi.org/10.3390/cancers15133395

Čerina, D., et al. (2023) 'The Challenges and Opportunities of the Implementation of Comprehensive Genomic Profiling in Everyday Clinical Practice with Non-Small Cell Lung Cancer: National Results from Croatia', Cancers, 15(13). doi: 10.3390/cancers15133395

Čerina D, Krpina K, Jakopović M, Dedić Plavetić N, Seiwerth F, Tomić S, i sur.. The Challenges and Opportunities of the Implementation of Comprehensive Genomic Profiling in Everyday Clinical Practice with Non-Small Cell Lung Cancer: National Results from Croatia. Cancers [Internet]. 28.06.2023. [pristupljeno 16.03.2025.];15(13). doi: 10.3390/cancers15133395

D. Čerina, et al., "The Challenges and Opportunities of the Implementation of Comprehensive Genomic Profiling in Everyday Clinical Practice with Non-Small Cell Lung Cancer: National Results from Croatia", Cancers, vol. 15, br. 13, Lipanj 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:378709. [Citirano: 16.03.2025.]

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Podaci o radu
Naslov (engleski)The Challenges and Opportunities of the Implementation of Comprehensive Genomic Profiling in Everyday Clinical Practice with Non-Small Cell Lung Cancer: National Results from Croatia
AutorDora Čerina
AutorKristina Krpina
AutorMarko Jakopović
AutorNatalija Dedić Plavetić
AutorFran Seiwerth
AutorSnježana Tomić
AutorJasna Radić
AutorIngrid Belac Lovasić
AutorIvana Canjko
AutorMarijo Boban
AutorMiroslav Samaržija
AutorEduard Vrdoljak
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PATOFIZIOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Patofiziologija
Sažetak (engleski)
Non–small cell lung cancer (NSCLC) has become the best example of precision oncology’s impact on outcomes in everyday clinical practice, significantly changing the expectations of all stakeholders, including medical professionals, society, and most importantly, patients. Consequently, the implementation of the precision oncology concept in medical systems, in order to achieve optimal and proven curative effects in NSCLC, is imperative. In this study, we investigated the development, challenges,... Više and results associated with the implementation of precision oncology in NSCLC on a national level in Croatia. We conducted a multicenter, retrospective, cross-sectional analysis on the total population of Croatian patients with metastatic lung cancer, on whose tumors specimen comprehensive genomic profiling (CGP) testing was performed during 2020 and 2021. A total of 48 patients were included in the study. CGP revealed clinically relevant genomic alterations (CRGA) in 37 patients (79%), with a median of 2 (IQR 1–3) CRGA per patient. From the panel of recommended tests, KRAS, MET, and EGFR were the most common alterations, detected in 16 (34%), 5 (11%), and 3 (6%) patients, respectively. CGP revealed additional targetable mutations in 29 (60%) patients who would not have been tested (and consequently, whose mutations would not have been detected) according to the existing everyday standard of practice in Croatia. The tumor mutational burden was reported as high (≥10 Muts/Mb) in 19 patients (40%). CGP analysis reported some kind of targeted therapy for 34 patients (72%). CGP revealed other potentially targetable mutations, and it also determined TMB to be high in a significant number of patients. In conclusion, when possible, CGP should be used as an upfront backbone diagnostic and treatment-oriented work-up in patients with NSCLC. Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCancers
Brojčani podacivol. 15, br. 13, 3395
e-ISSN2072-6694
DOIhttps://doi.org/10.3390/cancers15133395
URN:NBNurn:nbn:hr:105:378709
Datum objave publikacije2023-06-28
URL dokumentahttps://www.mdpi.com/2072-6694/15/13/3395
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-09-26 07:51:41
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