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Increased NLRP1 mRNA and Protein Expression Suggests Inflammasome Activation in the Dorsolateral Prefrontal and Medial Orbitofrontal Cortex in Schizophrenia
Biomolecules, 14 (2024), 3; 302. https://doi.org/10.3390/biom14030302
Španić Popovački, Ena; Vogrinc, Dora; Fuller, Heidi R.; Langer Horvat, Lea; Mayer, Davor; Kopić, Janja; Pintarić, Klara; Babić Leko, Mirjana; Pravica, Mihaela; Krsnik, Željka; Marčinko, Darko; Šagud, Marina; Hof, Patrick R.; Mladinov, Mihovil; Šimić, Goran Više autora...

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Španić Popovački, E., Vogrinc, D., Fuller, H. R., Langer Horvat, L., Mayer, D., Kopić, J. ... Šimić, G. (2024). Increased NLRP1 mRNA and Protein Expression Suggests Inflammasome Activation in the Dorsolateral Prefrontal and Medial Orbitofrontal Cortex in Schizophrenia. Biomolecules, 14. (3). doi: 10.3390/biom14030302

Španić Popovački, Ena, et al. "Increased NLRP1 mRNA and Protein Expression Suggests Inflammasome Activation in the Dorsolateral Prefrontal and Medial Orbitofrontal Cortex in Schizophrenia." Biomolecules, vol. 14, br. 3, 2024. https://doi.org/10.3390/biom14030302

Španić Popovački, Ena, Dora Vogrinc, Heidi R. Fuller, Lea Langer Horvat, Davor Mayer, Janja Kopić, Klara Pintarić, et al. "Increased NLRP1 mRNA and Protein Expression Suggests Inflammasome Activation in the Dorsolateral Prefrontal and Medial Orbitofrontal Cortex in Schizophrenia." Biomolecules 14, br. 3 (2024). https://doi.org/10.3390/biom14030302

Španić Popovački, E., et al. (2024) 'Increased NLRP1 mRNA and Protein Expression Suggests Inflammasome Activation in the Dorsolateral Prefrontal and Medial Orbitofrontal Cortex in Schizophrenia', Biomolecules, 14(3). doi: 10.3390/biom14030302

Španić Popovački E, Vogrinc D, Fuller HR, Langer Horvat L, Mayer D, Kopić J, i sur.. Increased NLRP1 mRNA and Protein Expression Suggests Inflammasome Activation in the Dorsolateral Prefrontal and Medial Orbitofrontal Cortex in Schizophrenia. Biomolecules [Internet]. 04.03.2024. [pristupljeno 02.12.2024.];14(3). doi: 10.3390/biom14030302

E. Španić Popovački, et al., "Increased NLRP1 mRNA and Protein Expression Suggests Inflammasome Activation in the Dorsolateral Prefrontal and Medial Orbitofrontal Cortex in Schizophrenia", Biomolecules, vol. 14, br. 3, Ožujak 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:372634. [Citirano: 02.12.2024.]

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Naslov (engleski)Increased NLRP1 mRNA and Protein Expression Suggests Inflammasome Activation in the Dorsolateral Prefrontal and Medial Orbitofrontal Cortex in Schizophrenia
AutorEna Španić Popovački
AutorDora Vogrinc
AutorHeidi R. Fuller
AutorLea Langer Horvat
AutorDavor Mayer
AutorJanja Kopić
AutorKlara Pintarić
AutorMirjana Babić Leko
AutorMihaela Pravica
AutorŽeljka Krsnik
AutorDarko Marčinko
AutorMarina Šagud
AutorPatrick R. Hof
AutorMihovil Mladinov
AutorGoran Šimić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(HRVATSKI INSTITUT ZA ISTRAŽIVANJE MOZGA)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA ANATOMIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PSIHIJATRIJU I PSIHOLOŠKU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Anatomija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Psihijatrija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Neuroznanost
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sudska medicina
Sažetak (engleski)
Schizophrenia is a complex mental condition, with key symptoms marked for diagnosis including delusions, hallucinations, disorganized thinking, reduced emotional expression, and social dysfunction. In the context of major developmental hypotheses of schizophrenia, notably those concerning maternal immune activation and neuroinflammation, we studied NLRP1 expression and content in the postmortem brain tissue of 10 schizophrenia and 10 control subjects. In the medial orbitofrontal cortex (Brodmann’s area 11/12) and dorsolateral prefrontal cortex (area 46) from both hemispheres of six schizophrenia subjects, the NLRP1 mRNA expression was significantly higher than in six control brains (p < 0.05). As the expression difference was highest for the medial orbitofrontal cortex in the right hemisphere, we assessed NLRP1-immunoreactive pyramidal neurons in layers III, V, and VI in the medial orbitofrontal cortex in the right hemisphere of seven schizophrenia and five control brains. Compared to controls, we quantified a significantly higher number of NLRP1-positive pyramidal neurons in the schizophrenia brains (p < 0.01), suggesting NLRP1 inflammasome activation in schizophrenia subjects. Layer III pyramidal neuron dysfunction aligns with working memory deficits, while impairments of pyramidal neurons in layers V and VI likely disrupt predictive processing. We propose NLRP1 inflammasome as a potential biomarker and therapeutic target in schizophrenia.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiomolecules
Brojčani podacivol. 14, br. 3, 302
e-ISSN2218-273X
DOIhttps://doi.org/10.3390/biom14030302
URN:NBNurn:nbn:hr:105:372634
Datum objave publikacije2024-03-04
ProjektŠifra: IP-2019-04-3584
Naziv (hrvatski): Uloga krvno-moždane barijere, urođene imunosti i oligomerizacije tau proteina u patogenezi Alzheimerove bolesti
Naziv (engleski): Role of blood-brain barrier, innate immunity, and tau protein oligomerization in the pathogenesis of Alzheimer's disease
Kratica: ALZ-BBB-INNATETAU
Voditelj: Goran Šimić
Pravna nadležnost: Hrvatska
Financijer: Hrvatska zaklada za znanost
Linija financiranja: Research Projects
ProjektŠifra: KK.01.1.1.01.0007
Naziv (hrvatski): Eksperimentalna i klinička istraživanja hipoksijsko-ishemijskog oštećenja mozga u perinatalnoj i odrasloj dobi
Naziv (engleski): .
Kratica: ZCI Neuro
Voditelj: Miloš Judaš
Pravna nadležnost: eu
Financijer: Europska komisija
Linija financiranja: European Regional Development Fund
URL dokumentahttps://www.mdpi.com/2218-273X/14/3/302
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-10-22 07:30:33