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Incretin Hormone Secretion in Women with Polycystic Ovary Syndrome: Roles of Obesity, Insulin Sensitivity and Treatment with Metformin and GLP-1s
Biomedicines, 12 (2024), 3; 653. https://doi.org/10.3390/biomedicines12030653
Etrusco, Andrea; Mikuš, Mislav; D’Amato, Antonio; Barra, Fabio; Planinić, Petar; Goluža, Trpimir; Buzzaccarini, Giovanni; Marušić, Jelena; Tešanović, Mara; Laganà, Antonio Simone

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Etrusco, A., Mikuš, M., D’Amato, A., Barra, F., Planinić, P., Goluža, T. ... Laganà, A. S. (2024). Incretin Hormone Secretion in Women with Polycystic Ovary Syndrome: Roles of Obesity, Insulin Sensitivity and Treatment with Metformin and GLP-1s. Biomedicines, 12. (3). doi: 10.3390/biomedicines12030653

Etrusco, Andrea, et al. "Incretin Hormone Secretion in Women with Polycystic Ovary Syndrome: Roles of Obesity, Insulin Sensitivity and Treatment with Metformin and GLP-1s." Biomedicines, vol. 12, br. 3, 2024. https://doi.org/10.3390/biomedicines12030653

Etrusco, Andrea, Mislav Mikuš, Antonio D’Amato, Fabio Barra, Petar Planinić, Trpimir Goluža, Giovanni Buzzaccarini, Jelena Marušić, Mara Tešanović i Antonio Simone Laganà. "Incretin Hormone Secretion in Women with Polycystic Ovary Syndrome: Roles of Obesity, Insulin Sensitivity and Treatment with Metformin and GLP-1s." Biomedicines 12, br. 3 (2024). https://doi.org/10.3390/biomedicines12030653

Etrusco, A., et al. (2024) 'Incretin Hormone Secretion in Women with Polycystic Ovary Syndrome: Roles of Obesity, Insulin Sensitivity and Treatment with Metformin and GLP-1s', Biomedicines, 12(3). doi: 10.3390/biomedicines12030653

Etrusco A, Mikuš M, D’Amato A, Barra F, Planinić P, Goluža T, i sur.. Incretin Hormone Secretion in Women with Polycystic Ovary Syndrome: Roles of Obesity, Insulin Sensitivity and Treatment with Metformin and GLP-1s. Biomedicines [Internet]. 14.03.2024. [pristupljeno 09.11.2024.];12(3). doi: 10.3390/biomedicines12030653

A. Etrusco, et al., "Incretin Hormone Secretion in Women with Polycystic Ovary Syndrome: Roles of Obesity, Insulin Sensitivity and Treatment with Metformin and GLP-1s", Biomedicines, vol. 12, br. 3, Ožujak 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:302957. [Citirano: 09.11.2024.]

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Naslov (engleski)Incretin Hormone Secretion in Women with Polycystic Ovary Syndrome: Roles of Obesity, Insulin Sensitivity and Treatment with Metformin and GLP-1s
AutorAndrea Etrusco
AutorMislav Mikuš
AutorAntonio D’Amato
AutorFabio Barra
AutorPetar Planinić
AutorTrpimir Goluža
AutorGiovanni Buzzaccarini
AutorJelena Marušić
AutorMara Tešanović
AutorAntonio Simone Laganà
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA GINEKOLOGIJU I OPSTETRICIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Ginekologija i opstetricija
Sažetak (engleski)
Background: The purpose of this narrative review is to describe the mechanisms that are responsible for the development of infertility and PCOS, with a focus on the role of obesity, insulin sensitivity and treatment with metformin and GLP-1s. Methods: The relevant publications were identified after systematic queries of the following sources: PubMed, Google Scholar, Web of Science, and publishers’ databases, complemented by a cross-check of the reference lists. We used a combination of the search terms “polycystic ovary syndrome”, “obesity” and “insulin resistance” with “metformin”, “exenatide”, “liraglutide”, “semaglutide”, “orlistat” and terms relevant to the topic of each paragraph (e.g., “pathophysiology”, “metabolism”, “infertility”, “treatment”). Results: All articles describing the mechanisms responsible for the development of infertility and PCOS, with a focus on the role of obesity, insulin sensitivity and treatment with metformin and GLP-1s, were considered for this review. Conclusions: The existing research on GLP-1 receptor agonists (GLP-1RAs) has not conclusively established a specific therapeutic use for these drugs. Additionally, the efficacy of the newer generation of GLP-1RAs, particularly in terms of dosage and duration of exposure, warrants more extensive research. Understanding the optimal dosing and treatment duration could significantly enhance the therapeutic use of GLP-1RAs in managing PCOS and its associated conditions.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiomedicines
Brojčani podacivol. 12, br. 3, 653
e-ISSN2227-9059
DOIhttps://doi.org/10.3390/biomedicines12030653
URN:NBNurn:nbn:hr:105:302957
Datum objave publikacije2024-03-14
URL dokumentahttps://www.mdpi.com/2227-9059/12/3/653
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-10-22 07:45:00