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Lasting mesothalamic dopamine imbalance and altered exploratory behavior in rats after a mild neonatal hypoxic event
Frontiers in Integrative Neuroscience, 17 (2024); 1304338. https://doi.org/10.3389/fnint.2023.1304338
Nikolić, Barbara; Trnski-Levak, Sara; Kosić, Kristina; Drlje, Matea; Banovac, Ivan; Hranilović, Dubravka; Jovanov-Milošević, Nataša

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Nikolić, B., Trnski Levak, S., Kosić, K., Drlje, M., Banovac, I., Hranilović, D. i Jovanov Milošević, N. (2024). Lasting mesothalamic dopamine imbalance and altered exploratory behavior in rats after a mild neonatal hypoxic event. Frontiers in Integrative Neuroscience, 17.. doi: 10.3389/fnint.2023.1304338

Nikolić, Barbara, et al. "Lasting mesothalamic dopamine imbalance and altered exploratory behavior in rats after a mild neonatal hypoxic event." Frontiers in Integrative Neuroscience, vol. 17, 2024. https://doi.org/10.3389/fnint.2023.1304338

Nikolić, Barbara, Sara Trnski Levak, Kristina Kosić, Matea Drlje, Ivan Banovac, Dubravka Hranilović i Nataša Jovanov Milošević. "Lasting mesothalamic dopamine imbalance and altered exploratory behavior in rats after a mild neonatal hypoxic event." Frontiers in Integrative Neuroscience 17 (2024). https://doi.org/10.3389/fnint.2023.1304338

Nikolić, B., et al. (2024) 'Lasting mesothalamic dopamine imbalance and altered exploratory behavior in rats after a mild neonatal hypoxic event', Frontiers in Integrative Neuroscience, 17. doi: 10.3389/fnint.2023.1304338

Nikolić B, Trnski Levak S, Kosić K, Drlje M, Banovac I, Hranilović D, i sur.. Lasting mesothalamic dopamine imbalance and altered exploratory behavior in rats after a mild neonatal hypoxic event. Frontiers in Integrative Neuroscience [Internet]. 17.01.2024. [pristupljeno 03.12.2024.];17. doi: 10.3389/fnint.2023.1304338

B. Nikolić, et al., "Lasting mesothalamic dopamine imbalance and altered exploratory behavior in rats after a mild neonatal hypoxic event", Frontiers in Integrative Neuroscience, vol. 17, Siječanj 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:475780. [Citirano: 03.12.2024.]

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Podaci o radu
Naslov (engleski)Lasting mesothalamic dopamine imbalance and altered exploratory behavior in rats after a mild neonatal hypoxic event
AutorBarbara Nikolić
AutorSara Trnski-Levak
AutorKristina Kosić
AutorMatea Drlje
AutorIvan Banovac
AutorDubravka Hranilović
AutorNataša Jovanov-Milošević
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(HRVATSKI INSTITUT ZA ISTRAŽIVANJE MOZGA)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA MEDICINSKU BIOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Introduction: Adversities during the perinatal period can decrease oxygen supply to the fetal brain, leading to various hypoxic brain injuries, which can compromise the regularity of brain development in different aspects. To examine the catecholaminergic contribution to the link between an early-life hypoxic insult and adolescent behavioral aberrations, we used a previously established rat model of perinatal hypoxia but altered the hypobaric to normobaric conditions. Methods: Exploratory and social behavior and learning abilities were tested in 70 rats of both sexes at adolescent age. Inherent vertical locomotion, sensory-motor functions and spatial learning abilities were explored in a subset of animals to clarify the background of altered exploratory behavior. Finally, the concentrations of dopamine (DA) and noradrenaline in midbrain and pons, and the relative expression of genes for DA receptors D1 and D2, and their down-stream targets (DA- and cAMP-regulated phosphoprotein, Mr 32 kDa, the regulatory subunit of protein kinase A, and inhibitor-5 of protein phosphatase 1) in the hippocampus and thalamus were investigated in 31 rats. Results: A lesser extent of alterations in exploratory and cognitive aspects of behavior in the present study suggests that normobaric conditions mitigate the hypoxic injury compared to the one obtained under hypobaric conditions. Increased exploratory rearing was the most prominent consequence, with impaired spatial learning in the background. In affected rats, increased midbrain/pons DA content, as well as mRNA levels for DA receptors and their down-stream elements in the thalamus, but not the hippocampus, were found. Conclusion: We can conclude that a mild hypoxic event induced long-lasting disbalances in mesothalamic DA signaling, contributing to the observed behavioral alterations. The thalamus was thereby indicated as another structure, besides the well-established striatum, involved in mediating hypoxic effects on behavior through DA signaling.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaFrontiers in Integrative Neuroscience
Brojčani podacivol. 17, 1304338
e-ISSN1662-5145
DOIhttps://doi.org/10.3389/fnint.2023.1304338
URN:NBNurn:nbn:hr:105:475780
Datum objave publikacije2024-01-17
ProjektŠifra: IP-2019-04-3182
Naziv (hrvatski): Moždani izvanstanični matriks u razvitku i perinatalnoj hipoksiji
Naziv (engleski): Brain extracellular matrix in development and in perinatal hypoxia
Kratica: BRAINECM
Voditelj: Nataša Jovanov Milošević
Pravna nadležnost: Hrvatska
Financijer: Hrvatska zaklada za znanost
Linija financiranja: Research Projects
ProjektŠifra: KK.01.1.1.01.0007
Naziv (hrvatski): Znanstveni centar izvrsnosti - eksperimentalna i klinička istraživanja hipoksijsko-ishemijskog oštećenja mozga u perinatalnoj i odrasloj dobi
Naziv (engleski): Scientific center of excellence - Experimental and clinical research of hypoxic-ischemic brain damage in perinatal and adulthood
Kratica: ZCI-NEURO
Voditelj: Miloš Judaš
Pravna nadležnost: eu
Financijer: Europska unija
Linija financiranja: European Regional Development Fund
URL dokumentahttps://www.frontiersin.org/articles/10.3389/fnint.2023.1304338/full
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-12-03 08:17:00