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Differentinating between non-transfusion dependant β-thalassemia and iron deficinecy anemia in children using ROC and logistic regression analysis: two novel discrimination indices designed for pediatric patients
Frontiers in Pediatrics, 11 (2024); 1258054. https://doi.org/10.3389/fped.2023.1258054
Turudić, Daniel; Vučak, Jerko; Kocheva, Svetlana; Milošević, Danko; Bilić, Ernest

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Turudić, D., Vučak, J., Kocheva, S., Milošević, D. i Bilić, E. (2024). Differentinating between non-transfusion dependant β-thalassemia and iron deficinecy anemia in children using ROC and logistic regression analysis: two novel discrimination indices designed for pediatric patients. Frontiers in Pediatrics, 11.. doi: 10.3389/fped.2023.1258054

Turudić, Daniel, et al. "Differentinating between non-transfusion dependant β-thalassemia and iron deficinecy anemia in children using ROC and logistic regression analysis: two novel discrimination indices designed for pediatric patients." Frontiers in Pediatrics, vol. 11, 2024. https://doi.org/10.3389/fped.2023.1258054

Turudić, Daniel, Jerko Vučak, Svetlana Kocheva, Danko Milošević i Ernest Bilić. "Differentinating between non-transfusion dependant β-thalassemia and iron deficinecy anemia in children using ROC and logistic regression analysis: two novel discrimination indices designed for pediatric patients." Frontiers in Pediatrics 11 (2024). https://doi.org/10.3389/fped.2023.1258054

Turudić, D., et al. (2024) 'Differentinating between non-transfusion dependant β-thalassemia and iron deficinecy anemia in children using ROC and logistic regression analysis: two novel discrimination indices designed for pediatric patients', Frontiers in Pediatrics, 11. doi: 10.3389/fped.2023.1258054

Turudić D, Vučak J, Kocheva S, Milošević D, Bilić E. Differentinating between non-transfusion dependant β-thalassemia and iron deficinecy anemia in children using ROC and logistic regression analysis: two novel discrimination indices designed for pediatric patients. Frontiers in Pediatrics [Internet]. 16.01.2024. [pristupljeno 14.03.2025.];11. doi: 10.3389/fped.2023.1258054

D. Turudić, J. Vučak, S. Kocheva, D. Milošević i E. Bilić, "Differentinating between non-transfusion dependant β-thalassemia and iron deficinecy anemia in children using ROC and logistic regression analysis: two novel discrimination indices designed for pediatric patients", Frontiers in Pediatrics, vol. 11, Siječanj 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:864772. [Citirano: 14.03.2025.]

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Naslov (engleski)Differentinating between non-transfusion dependant β-thalassemia and iron deficinecy anemia in children using ROC and logistic regression analysis: two novel discrimination indices designed for pediatric patients
AutorDaniel Turudić
AutorJerko Vučak
AutorSvetlana Kocheva
AutorDanko Milošević
AutorErnest Bilić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PEDIJATRIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Pedijatrija
Sažetak (engleski)
Introduction: This cross-sectional study enrolled a group of 271 children with microcytic anemia in order to test the performance of 41 single and 2 composite formulas andindices in distinguishing between β-thalassemia (β-thal) and iron deficiency anemia (IDA) in the pediatric population. Methods: Optimal pediatric cut-off values from the previously published formulas and indices were generated using ROC analysis. Logistic regression in R using generalized linear models (GLM) generated two new indices. Results: Formulas and indices with optimal cut-offvalues in children with accuracy ≥90% were (in descending order): Matos & Carvalho index, MDHL(Telmissani) formula, England and Fraser formula, Pornprasert index, Sirachainan index, Telmissani (MCHD) formula, CRUISE index, Hameed index, Sargolzaie formula and Zaghloul II index. The CroThalDD-LM1 index has an accuracy of 93.36% (AUC 0.986, 95% CI 0.975-0.997), while the second CroThalDD-LM2 index utilizes absolute reticulocyte count alongside CBC variables, with an accuracy of 96.77% (AUC 0.985, 95% CI 0.988-0.999). Discussion and conclusion: We recommend using aforementioned formulas and indices with corrected cut-off values and accuracy >90% alongside two new proposed indices. A comparison of both native and these new indices is encouraged. These are the first discrimination indices generated and designed precisely for the pediatric population, which includes preschool children.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaFrontiers in Pediatrics
Brojčani podacivol. 11, 1258054
e-ISSN2296-2360
DOIhttps://doi.org/10.3389/fped.2023.1258054
URN:NBNurn:nbn:hr:105:864772
Datum objave publikacije2024-01-16
URL dokumentahttps://www.frontiersin.org/articles/10.3389/fped.2023.1258054/full
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-12-03 08:27:12