prikaz prve stranice dokumenta Neutrophil-mediated type IV collagen degradation is elevated in patients with mild endoscopic ulcerative colitis reflecting early mucosal destruction
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Neutrophil-mediated type IV collagen degradation is elevated in patients with mild endoscopic ulcerative colitis reflecting early mucosal destruction
Scientific Reports, 14 (2024), 1; 1641. https://doi.org/10.1038/s41598-024-52208-y
Alexdottir, Marta S.; Pehrsson, Martin; Domislović, Viktor; Godskesen, Line E.; Krag, Aleksander; Kjeldsen, Jens; Brinar, Marko; Barišić, Ana; Bay-Jensen, Anne-Christine; Karsdal, Morten A.; Krznarić, Željko; Mortensen, Joachim H.

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Alexdottir, M. S., Pehrsson, M., Domislović, V., Godskesen, L. E., Krag, A., Kjeldsen, J. ... Mortensen, J. H. (2024). Neutrophil-mediated type IV collagen degradation is elevated in patients with mild endoscopic ulcerative colitis reflecting early mucosal destruction. Scientific Reports, 14. (1). doi: 10.1038/s41598-024-52208-y

Alexdottir, Marta S., et al. "Neutrophil-mediated type IV collagen degradation is elevated in patients with mild endoscopic ulcerative colitis reflecting early mucosal destruction." Scientific Reports, vol. 14, br. 1, 2024. https://doi.org/10.1038/s41598-024-52208-y

Alexdottir, Marta S., Martin Pehrsson, Viktor Domislović, Line E. Godskesen, Aleksander Krag, Jens Kjeldsen, Marko Brinar, et al. "Neutrophil-mediated type IV collagen degradation is elevated in patients with mild endoscopic ulcerative colitis reflecting early mucosal destruction." Scientific Reports 14, br. 1 (2024). https://doi.org/10.1038/s41598-024-52208-y

Alexdottir, M. S., et al. (2024) 'Neutrophil-mediated type IV collagen degradation is elevated in patients with mild endoscopic ulcerative colitis reflecting early mucosal destruction', Scientific Reports, 14(1). doi: 10.1038/s41598-024-52208-y

Alexdottir MS, Pehrsson M, Domislović V, Godskesen LE, Krag A, Kjeldsen J, i sur.. Neutrophil-mediated type IV collagen degradation is elevated in patients with mild endoscopic ulcerative colitis reflecting early mucosal destruction. Scientific Reports [Internet]. 18.01.2024. [pristupljeno 10.12.2024.];14(1). doi: 10.1038/s41598-024-52208-y

M. S. Alexdottir, et al., "Neutrophil-mediated type IV collagen degradation is elevated in patients with mild endoscopic ulcerative colitis reflecting early mucosal destruction", Scientific Reports, vol. 14, br. 1, Siječanj 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:454161. [Citirano: 10.12.2024.]

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Naslov (engleski)Neutrophil-mediated type IV collagen degradation is elevated in patients with mild endoscopic ulcerative colitis reflecting early mucosal destruction
AutorMarta S. Alexdottir
AutorMartin Pehrsson
AutorViktor Domislović
AutorLine E. Godskesen
AutorAleksander Krag
AutorJens Kjeldsen
AutorMarko Brinar
AutorAna Barišić
AutorAnne-Christine Bay-Jensen
AutorMorten A. Karsdal
AutorŽeljko Krznarić
MBZ: 75865
AutorJoachim H. Mortensen
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Neutrophils play a significant role in sustaining chronic inflammation in Inflammatory Bowel Disease. The intestinal basement membrane acts as a barrier for immunological homeostasis, where the α3 and α4 chains of type IV collagen are expressed on the mucosal surface. We wanted to develop a biomarker reflecting early tissue injury, providing an opportunity for intervention. Two competitive enzyme-linked immunosorbent assays (ELISAs) quantifying human neutrophil elastase (HNE) degraded neo-epitopes of COL4A3 and COL4A4 were developed and investigated in two observational cohorts (n = 161, n = 100). A biomarker of MMP-mediated degradation of COL4A1 (C4M) was used for comparison. In Cohort 1, patients with mild endoscopic ulcerative colitis showed elevated levels of C4A3-HNE compared to those with severe disease. C4M had a strong positive correlation with disease activity. C4A3-HNE/C4M provided superior discrimination between mild and severe endoscopic disease and negatively correlated to disease activity. In Cohort 2, C4A4-HNE and C4A4-HNE/C4M showed similar trends. C4A3-HNE and C4A4-HNE possibly reflect early intestinal tissue injury. Combining the markers with a biomarker of another α-chain of the same collagen provides information on two distinct stages of mucosal damage. These biomarkers may be used to monitor disease flare-up in patients in remission, reducing the need for frequent endoscopic procedures.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaScientific Reports
Brojčani podacivol. 14, br. 1, 1641
e-ISSN2045-2322
DOIhttps://doi.org/10.1038/s41598-024-52208-y
URN:NBNurn:nbn:hr:105:454161
Datum objave publikacije2024-01-18
URL dokumentahttps://www.nature.com/articles/s41598-024-52208-y
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-12-10 08:33:41