prikaz prve stranice dokumenta The Absence of Gastrointestinal Redox Dyshomeostasis in the Brain-First Rat Model of Parkinson’s Disease Induced by Bilateral Intrastriatal 6-Hydroxydopamine
  Preuzmi
PDF 1.68 MB
Znanstveni rad - Izvorni znanstveni rad
The Absence of Gastrointestinal Redox Dyshomeostasis in the Brain-First Rat Model of Parkinson’s Disease Induced by Bilateral Intrastriatal 6-Hydroxydopamine
Molecular Neurobiology, 61 (2024), 8; 5481-5493. https://doi.org/10.1007/s12035-023-03906-7
Homolak, Jan; Joja, Mihovil; Grabaric, Gracia; Schiatti, Emiliano; Virag, Davor; Babić Perhoč, Ana; Knezović, Ana; Osmanović Barilar, Jelena; Šalkovic-Petrišić, Melita

Citirajte ovaj rad

Homolak, J., Joja, M., Grabaric, G., Schiatti, E., Virag, D., Babić Perhoč, A. ... Šalkovic Petrišić, M. (2024). The Absence of Gastrointestinal Redox Dyshomeostasis in the Brain-First Rat Model of Parkinson’s Disease Induced by Bilateral Intrastriatal 6-Hydroxydopamine. Molecular Neurobiology, 61. (8), 5481-5493. doi: 10.1007/s12035-023-03906-7

Homolak, Jan, et al. "The Absence of Gastrointestinal Redox Dyshomeostasis in the Brain-First Rat Model of Parkinson’s Disease Induced by Bilateral Intrastriatal 6-Hydroxydopamine." Molecular Neurobiology, vol. 61, br. 8, 2024, str. 5481-5493. https://doi.org/10.1007/s12035-023-03906-7

Homolak, Jan, Mihovil Joja, Gracia Grabaric, Emiliano Schiatti, Davor Virag, Ana Babić Perhoč, Ana Knezović, Jelena Osmanović Barilar i Melita Šalkovic Petrišić. "The Absence of Gastrointestinal Redox Dyshomeostasis in the Brain-First Rat Model of Parkinson’s Disease Induced by Bilateral Intrastriatal 6-Hydroxydopamine." Molecular Neurobiology 61, br. 8 (2024): 5481-5493. https://doi.org/10.1007/s12035-023-03906-7

Homolak, J., et al. (2024) 'The Absence of Gastrointestinal Redox Dyshomeostasis in the Brain-First Rat Model of Parkinson’s Disease Induced by Bilateral Intrastriatal 6-Hydroxydopamine', Molecular Neurobiology, 61(8), str. 5481-5493. doi: 10.1007/s12035-023-03906-7

Homolak J, Joja M, Grabaric G, Schiatti E, Virag D, Babić Perhoč A, i sur.. The Absence of Gastrointestinal Redox Dyshomeostasis in the Brain-First Rat Model of Parkinson’s Disease Induced by Bilateral Intrastriatal 6-Hydroxydopamine. Molecular Neurobiology [Internet]. 10.01.2024. [pristupljeno 11.12.2024.];61(8):5481-5493. doi: 10.1007/s12035-023-03906-7

J. Homolak, et al., "The Absence of Gastrointestinal Redox Dyshomeostasis in the Brain-First Rat Model of Parkinson’s Disease Induced by Bilateral Intrastriatal 6-Hydroxydopamine", Molecular Neurobiology, vol. 61, br. 8, str. 5481-5493, Siječanj 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:674241. [Citirano: 11.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:674241
Prijavite se u repozitorij kako biste mogli spremiti objekt u svoju listu.
Podaci o radu
Naslov (engleski)The Absence of Gastrointestinal Redox Dyshomeostasis in the Brain-First Rat Model of Parkinson’s Disease Induced by Bilateral Intrastriatal 6-Hydroxydopamine
AutorJan Homolak
AutorMihovil Joja
AutorGracia Grabaric
AutorEmiliano Schiatti
AutorDavor Virag
AutorAna Babić Perhoč
AutorAna Knezović
AutorJelena Osmanović Barilar
AutorMelita Šalkovic-Petrišić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA TEMELJNU I KLINIČKU FARMAKOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Farmakologija
Sažetak (engleski)
The gut-brain axis plays an important role in Parkinson’s disease (PD) by acting as a route for vagal propagation of aggregated α-synuclein in the gut-first endophenotype and as a mediator of gastrointestinal dyshomeostasis via the nigro-vagal pathway in the brain-first endophenotype of the disease. One important mechanism by which the gut-brain axis may promote PD is by regulating gastrointestinal redox homeostasis as overwhelming evidence suggests that oxidative stress plays a key role in the etiopathogenesis and progression of PD and the gastrointestinal tract maintains redox homeostasis of the organism by acting as a critical barrier to environmental and microbiological electrophilic challenges. The present aim was to utilize the bilateral intrastriatal 6-hydroxydopamine (6-OHDA) brain-first PD model to study the effects of isolated central pathology on redox homeostasis of the gastrointestinal tract. Three-month-old male Wistar rats were either not treated (intact controls; CTR) or treated bilaterally intrastriatally with vehicle (CIS) or 6-OHDA (6-OHDA). Motor deficits were assessed with the rotarod performance test, and the duodenum, ileum, and colon were dissected for biochemical analyses 12 weeks after the treatment. Lipid peroxidation, total antioxidant capacity, low-molecular-weight thiols, and protein sulfhydryls, the activity of total and Mn/Fe superoxide dismutases, and total and azide-insensitive catalase/peroxidase were measured. Both univariate and multivariate models analyzing redox biomarkers indicate that significant disturbances in gastrointestinal redox balance are not present. The findings demonstrate that motor impairment observed in the brain-first 6-OHDA model of PD can occur without concurrent redox imbalances in the gastrointestinal system.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaMolecular Neurobiology
Brojčani podacivol. 61, br. 8, str. 5481-5493
p-ISSN0893-7648
e-ISSN1559-1182
DOIhttps://doi.org/10.1007/s12035-023-03906-7
URN:NBNurn:nbn:hr:105:674241
Datum objave publikacije2024-01-10
ProjektŠifra: IP-2018-01-8938
Naziv (hrvatski): Mehanizmi nutrijentom posredovanih učinaka endogenog glukagonu sličnog peptida-1 na kognitivne i metaboličke poremećaje u eksperimentalnim modelima neurodegenerativnih bolesti
Naziv (engleski): Mechanisms of nutrient-mediated effects of endogenous glucagone-like peptide -1 on cognitive and metabolic alterations in experimental models of neurodegenerative disorders
Kratica: NutrientGLP-1
Voditelj: Melita Šalković-Petrišić
Pravna nadležnost: Hrvatska
Financijer: Hrvatska zaklada za znanost
Linija financiranja: Research Projects
ProjektŠifra: KK.01.1.1.01.0007
Naziv (hrvatski): Znanstveni centar izvrsnosti - eksperimentalna i klinička istraživanja hipoksijsko-ishemijskog oštećenja mozga u perinatalnoj i odrasloj dobi
Naziv (engleski): Scientific center of excellence - Experimental and clinical research of hypoxic-ischemic brain damage in perinatal and adulthood
Kratica: ZCI-NEURO
Voditelj: Miloš Judaš
Pravna nadležnost: eu
Financijer: Europska unija
Linija financiranja: European Regional Development Fund
URL dokumentahttps://link.springer.com/10.1007/s12035-023-03906-7
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-12-11 14:44:50