Exploring Acute Pancreatitis in Kidney Transplant Recipients: A Multicentre Retrospective Cohort Analysis of Incidence, Causes, and Clinical Outcomes

Znanstveni rad - Izvorni znanstveni rad

• Autor: Nikolina Bašić-Jukić
• Autor: Alen Andrović
• Autor: David Beck
• Autor: Danilo Radunović
• Autor: Ivana Jurić
• Autor: Vesna Furić-Čunko
• Autor: Lea Katalinić
• Autor: Zoran Sabljić
• Autor: Margareta Fištrek-Prlić
• Autor: Armin Atić
• Autor: Marina Kljajić
• Autor: Bojan Jelaković
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet; (KATEDRA ZA INTERNU MEDICINU)
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Kliničke medicinske znanosti; Interna medicina

Sažetak (engleski)

Background: The aim of this multicentre retrospective study is to determine the incidence, etiology, clinical characteristics, and outcomes of kidney transplant recipients diagnosed and treated for acute pancreatitis.
Methods: We analyzed data from kidney transplant recipients who received kidney allografts between October 1973 and December 2023 and were diagnosed and treated for acute pancreatitis.
Results: Of 2482 patients who received kidney allografts, 10 (0.4%) (5 male) were diagnosed with acute pancreatitis, with a mean age of 48.6 years. Patients were diagnosed with acute pancreatitis between 3 weeks and 24 years after the transplantation. Possible etiologies included cholecystolithiasis, COVID-19, hypercalcemia, postprocedural, use of cannabis, trimetoprim-sulphometoxasole, statins, sirolimus, tacrolimus and obesity. There was no suspected etiology in two patients. Patients were treated with aggressive hydration, pain alleviation and antibiotics if indicated. Four patients developed complications. Local complications included peripancreatic collections, pseudocyst, and abscesses formation, while systemic complications occurred in the form of Cytomegalovirus (CMV) reactivation and urinary tract infection. All patients survived with preserved kidney allograft function.
Conclusions: Acute pancreatitis in kidney transplant recipients is rare. However, it may be linked to significant morbidity and mortality. While symptoms may be nonspecific and brought on by a variety of viral and non-infectious illnesses, as well as adverse effects from immunosuppressive medications, a high degree of awareness is required.

• Ključne riječi (engleski): acute pancreatitis; cannabis; kidney transplantation; sirolimus; tacrolimus
• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Izvorni znanstveni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: Journal of Clinical Medicine
• Brojčani podaci: vol. 13, br. 12, 3366
• e-ISSN: 2077-0383
• DOI: https://doi.org/10.3390/jcm13123366
• URN:NBN: urn:nbn:hr:105:099177
• Datum objave publikacije: 2024-06-07
• URL dokumenta: https://www.mdpi.com/2077-0383/13/12/3366
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2024-12-18 11:24:47