prikaz prve stranice dokumenta Moderate SCRIB Expression Levels Correlate with Worse Prognosis in OPSCC Patients Regardless of HPV Status
  Preuzmi
PDF 1.65 MB
Znanstveni rad - Izvorni znanstveni rad
Moderate SCRIB Expression Levels Correlate with Worse Prognosis in OPSCC Patients Regardless of HPV Status
Cells, 13 (2024), 12; 1002. https://doi.org/10.3390/cells13121002
Lulić, Lucija; Šimić, Ivana; Božinović, Ksenija; Pešut, Ena; Manojlović, Luka; Grce, Magdalena; Dediol, Emil; Sabol, Ivan; Tomaić, Vjekoslav

Citirajte ovaj rad

Lulić, L., Šimić, I., Božinović, K., Pešut, E., Manojlović, L., Grce, M. ... Tomaić, V. (2024). Moderate SCRIB Expression Levels Correlate with Worse Prognosis in OPSCC Patients Regardless of HPV Status. Cells, 13. (12). doi: 10.3390/cells13121002

Lulić, Lucija, et al. "Moderate SCRIB Expression Levels Correlate with Worse Prognosis in OPSCC Patients Regardless of HPV Status." Cells, vol. 13, br. 12, 2024. https://doi.org/10.3390/cells13121002

Lulić, Lucija, Ivana Šimić, Ksenija Božinović, Ena Pešut, Luka Manojlović, Magdalena Grce, Emil Dediol, Ivan Sabol i Vjekoslav Tomaić. "Moderate SCRIB Expression Levels Correlate with Worse Prognosis in OPSCC Patients Regardless of HPV Status." Cells 13, br. 12 (2024). https://doi.org/10.3390/cells13121002

Lulić, L., et al. (2024) 'Moderate SCRIB Expression Levels Correlate with Worse Prognosis in OPSCC Patients Regardless of HPV Status', Cells, 13(12). doi: 10.3390/cells13121002

Lulić L, Šimić I, Božinović K, Pešut E, Manojlović L, Grce M, i sur.. Moderate SCRIB Expression Levels Correlate with Worse Prognosis in OPSCC Patients Regardless of HPV Status. Cells [Internet]. 08.06.2024. [pristupljeno 15.03.2025.];13(12). doi: 10.3390/cells13121002

L. Lulić, et al., "Moderate SCRIB Expression Levels Correlate with Worse Prognosis in OPSCC Patients Regardless of HPV Status", Cells, vol. 13, br. 12, Lipanj 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:572676. [Citirano: 15.03.2025.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:572676
Prijavite se u repozitorij kako biste mogli spremiti objekt u svoju listu.
Podaci o radu
Naslov (engleski)Moderate SCRIB Expression Levels Correlate with Worse Prognosis in OPSCC Patients Regardless of HPV Status
AutorLucija Lulić
AutorIvana Šimić
AutorKsenija Božinović
AutorEna Pešut
AutorLuka Manojlović
AutorMagdalena Grce
AutorEmil Dediol
AutorIvan Sabol
AutorVjekoslav Tomaić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA MAKSILOFACIJALNU KIRURGIJU SA STOMATOLOGIJOM)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Kirurgija
Sažetak (engleski)
Head and neck cancers rank as the sixth most prevalent cancers globally. In addition to traditional risk factors such as smoking and alcohol use, human papillomavirus (HPV) infections are becoming a significant causative agent of head and neck cancers, particularly among Western populations. Although HPV offers a significant survival benefit, the search for better biomarkers is still ongoing. In the current study, our objective was to investigate whether the expression levels of three PDZ-domain-containing proteins (SCRIB, NHERF2, and DLG1), known HPV E6 cellular substrates, influence the survival of HNSCC patients treated by primary surgery (n = 48). Samples were derived from oropharyngeal and oral cancers, and HPV presence was confirmed by PCR and p16 staining. Clinical and follow-up information was obtained from the hospital database and the Croatian Cancer registry up to November 2023. Survival was evaluated using the Kaplan–Meier method and Cox proportional hazard regression. The results were corroborated through the reanalysis of a comparable subset of TCGA cancer patients (n = 391). In conclusion, of the three targets studied, only SCRIB levels were found to be an independent predictor of survival in the Cox regression analysis, along with tumor stage. Further studies in a more typical Western population setting are needed since smoking and alcohol consumption are still prominent in the Croatian population, while the strongest association between survival and SCRIB levels was seen in HPV-negative cases.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCells
Brojčani podacivol. 13, br. 12, 1002
e-ISSN2073-4409
DOIhttps://doi.org/10.3390/cells13121002
URN:NBNurn:nbn:hr:105:572676
Datum objave publikacije2024-06-08
ProjektŠifra: IP-2013-11-4758
Naziv (hrvatski): Epigenetičke promjene karcinoma pločastih stanica glave i vrata
Naziv (engleski): Epigenetic changes in head and neck squamous cell carcinoma
Kratica: EpiC-HNSCC
Voditelj: Magdalena Grce
Pravna nadležnost: Hrvatska
Financijer: Hrvatska zaklada za znanost
Linija financiranja: Research Projects
URL dokumentahttps://www.mdpi.com/2073-4409/13/12/1002
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2025-01-22 13:08:11