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Are comorbidities of patients with adrenal incidentaloma tied to sex?
Frontiers in Endocrinology, 15 (2024); 1385808. https://doi.org/10.3389/fendo.2024.1385808
Puglisi, Soraya; Barač Nekić, Anja; Morelli, Valentina; Alessi, Ylenia; Fosci, Michele; Pani, Angelo; Zibar Tomšić, Karin; Palmieri, Serena; Ferraù, Francesco; Pia, Anna; Chiodini, Iacopo; Kaštelan, Darko; Reimondo, Giuseppe; Terzolo, Massimo

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Puglisi, S., Barač Nekić, A., Morelli, V., Alessi, Y., Fosci, M., Pani, A. ... Terzolo, M. (2024). Are comorbidities of patients with adrenal incidentaloma tied to sex?. Frontiers in Endocrinology, 15.. doi: 10.3389/fendo.2024.1385808

Puglisi, Soraya, et al. "Are comorbidities of patients with adrenal incidentaloma tied to sex?." Frontiers in Endocrinology, vol. 15, 2024. https://doi.org/10.3389/fendo.2024.1385808

Puglisi, Soraya, Anja Barač Nekić, Valentina Morelli, Ylenia Alessi, Michele Fosci, Angelo Pani, Karin Zibar Tomšić, et al. "Are comorbidities of patients with adrenal incidentaloma tied to sex?." Frontiers in Endocrinology 15 (2024). https://doi.org/10.3389/fendo.2024.1385808

Puglisi, S., et al. (2024) 'Are comorbidities of patients with adrenal incidentaloma tied to sex?', Frontiers in Endocrinology, 15. doi: 10.3389/fendo.2024.1385808

Puglisi S, Barač Nekić A, Morelli V, Alessi Y, Fosci M, Pani A, i sur.. Are comorbidities of patients with adrenal incidentaloma tied to sex?. Frontiers in Endocrinology [Internet]. 14.05.2024. [pristupljeno 14.03.2025.];15. doi: 10.3389/fendo.2024.1385808

S. Puglisi, et al., "Are comorbidities of patients with adrenal incidentaloma tied to sex?", Frontiers in Endocrinology, vol. 15, Svibanj 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:819421. [Citirano: 14.03.2025.]

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Naslov (engleski)Are comorbidities of patients with adrenal incidentaloma tied to sex?
AutorSoraya Puglisi
AutorAnja Barač Nekić
AutorValentina Morelli
AutorYlenia Alessi
AutorMichele Fosci
AutorAngelo Pani
AutorKarin Zibar Tomšić
AutorSerena Palmieri
AutorFrancesco Ferraù
AutorAnna Pia
AutorIacopo Chiodini
AutorDarko Kaštelan
AutorGiuseppe Reimondo
AutorMassimo Terzolo
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Background: A recent cross-sectional study showed that both comorbidities and mortality in patients with adrenal incidentaloma (AI) are tied to sex. However, few longitudinal studies evaluated the development of arterial hypertension, hyperglycemia, dyslipidemia and bone impairment in patients with AI. The aim of this study is to analyze the impact of sex in the development of these comorbidities during long-term follow-up. Methods: We retrospectively evaluated 189 patients (120 females, 69... Više males) with AI, from four referral centers in Italy and Croatia. Clinical characteristics, comorbidities and cortisol after 1-mg dexamethasone suppression test (1-mg DST) were assessed at baseline and at last follow-up visit (LFUV). Median follow-up was 52 (Interquartile Range 25-86) months. Results: The rates of arterial hypertension and hyperglycemia increased over time both in females (65.8% at baseline versus 77.8% at LFUV, p=0.002; 23.7% at baseline versus 39.6% at LFUV, p<0.001; respectively) and males (58.0% at baseline versus 69.1% at LFUV, p=0.035; 33.8% at baseline versus 54.0% at LFUV, p<0.001; respectively). Patients were stratified in two groups using 1.8 µg/dl as cut-off of cortisol following 1-mg DST: non-functional adrenal tumors (NFAT) and tumors with mild autonomous cortisol secretion (MACS). In the NFAT group (99 patients, females 62.6%), at baseline, we did not observe any difference in clinical characteristics and comorbidities between males and females. At LFUV, males showed a higher frequency of hyperglycemia than females (57.6% versus 33.9%, p=0.03). In the MACS group (89 patients, females 64.0%), at baseline, the prevalence of hypertension, hyperglycemia and dyslipidemia was similar between sexes, despite females were younger (60, IQR 55-69 versus 67.5, IQR 61-73, years; p=0.01). Moreover, females presented higher rates of bone impairment (89.3% versus 54.5%, p=0.02) than males. At LFUV, a similar sex-related pattern was observed. Conclusion: Patients with AI frequently develop arterial hypertension and hyperglycemia and should be periodically checked for these comorbidities, regardless of sex. In patients with MACS, the lack of difference between sexes in the frequency of cardiometabolic comorbidities despite that females are younger, and the higher frequency of bone impairment in females, suggest a sex-specific effect of cortisol. Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaFrontiers in Endocrinology
Brojčani podacivol. 15, 1385808
e-ISSN1664-2392
DOIhttps://doi.org/10.3389/fendo.2024.1385808
URN:NBNurn:nbn:hr:105:819421
Datum objave publikacije2024-05-14
URL dokumentahttps://www.frontiersin.org/articles/10.3389/fendo.2024.1385808/full
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2025-02-03 12:53:41
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