prikaz prve stranice dokumenta Chronic hyperglycemia and intracranial meningiomas
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Chronic hyperglycemia and intracranial meningiomas
BMC Cancer, 24 (2024), 1; 488. https://doi.org/10.1186/s12885-024-12243-4
Orešković, Darko; Madero Pohlen, A.; Cvitković, Ivna; Alen, J.F.; Raguž, Marina; Álvarez-Sala de la Cuadra, A.; Bazarra Castro, G.J.; Bušić, Željko; Konstantinović, Ivan; Ledenko, Vlatko; Martínez Macho, C.; Müller, Danko; Žarak, Marko; Jovanov-Milošević, Nataša; Chudy, Darko; Marinović, Tonko Više autora...

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Orešković, D., Madero Pohlen, A., Cvitković, I., Alen, J., Raguž, M., Álvarez Sala de la Cuadra, A. ... Marinović, T. (2024). Chronic hyperglycemia and intracranial meningiomas. BMC Cancer, 24. (1). doi: 10.1186/s12885-024-12243-4

Orešković, Darko, et al. "Chronic hyperglycemia and intracranial meningiomas." BMC Cancer, vol. 24, br. 1, 2024. https://doi.org/10.1186/s12885-024-12243-4

Orešković, Darko, A. Madero Pohlen, Ivna Cvitković, J.F. Alen, Marina Raguž, A. Álvarez Sala de la Cuadra, G.J. Bazarra Castro, et al. "Chronic hyperglycemia and intracranial meningiomas." BMC Cancer 24, br. 1 (2024). https://doi.org/10.1186/s12885-024-12243-4

Orešković, D., et al. (2024) 'Chronic hyperglycemia and intracranial meningiomas', BMC Cancer, 24(1). doi: 10.1186/s12885-024-12243-4

Orešković D, Madero Pohlen A, Cvitković I, Alen J, Raguž M, Álvarez Sala de la Cuadra A, i sur.. Chronic hyperglycemia and intracranial meningiomas. BMC Cancer [Internet]. 17.04.2024. [pristupljeno 05.04.2025.];24(1). doi: 10.1186/s12885-024-12243-4

D. Orešković, et al., "Chronic hyperglycemia and intracranial meningiomas", BMC Cancer, vol. 24, br. 1, Travanj 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:654369. [Citirano: 05.04.2025.]

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Podaci o radu
Naslov (engleski)Chronic hyperglycemia and intracranial meningiomas
AutorDarko Orešković
AutorA. Madero Pohlen
AutorIvna Cvitković
AutorJ.F. Alen
AutorMarina Raguž
AutorA. Álvarez-Sala de la Cuadra
AutorG.J. Bazarra Castro
AutorŽeljko Bušić
AutorIvan Konstantinović
AutorVlatko Ledenko
AutorC. Martínez Macho
AutorDanko Müller
AutorMarko Žarak
AutorNataša Jovanov-Milošević
AutorDarko Chudy
AutorTonko Marinović
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(HRVATSKI INSTITUT ZA ISTRAŽIVANJE MOZGA)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA KIRURGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA MEDICINSKU BIOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Kirurgija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Citologija, histologija i embriologija
Sažetak (engleski)
Meningiomas are among the most common primary tumors of the central nervous system. Previous research into the meningioma histological appearance, genetic markers, transcriptome and epigenetic landscape has revealed that benign meningiomas significantly differ in their glucose metabolism compared to aggressive lesions. However, a correlation between the systemic glucose metabolism and the metabolism of the tumor hasn't yet been found. We hypothesized that chronic levels of glycaemia (approximated with glycated hemoglobin (HbA1c)) are different in patients with aggressive and benign meningiomas. The study encompassed 71 patients with de novo intracranial meningiomas, operated on in three European hospitals, two in Croatia and one in Spain. Our results show that patients with WHO grade 2 meningiomas had significantly higher HbA1c values compared to patients with grade 1 lesions (P = 0.0290). We also found a significant number of patients (19/71; 26.7%) being hyperglycemic, harboring all the risks that such a condition entails. Finally, we found a significant correlation between our patients' age and their preoperative HbA1c levels (P = 0.0008, ρ(rho) = 0.388), suggesting that older meningioma patients are at a higher risk of having their glycaemia severely dysregulated. These findings are especially important considering the current routine and wide-spread use of corticosteroids as anti-edematous treatment. Further research in this area could lead to better understanding of meningiomas and have immediate clinical impact.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBMC Cancer
Brojčani podacivol. 24, br. 1, 488
e-ISSN1471-2407
DOIhttps://doi.org/10.1186/s12885-024-12243-4
URN:NBNurn:nbn:hr:105:654369
Datum objave publikacije2024-04-17
URL dokumentahttps://bmccancer.biomedcentral.com/articles/10.1186/s12885-024-12243-4
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2025-03-06 09:32:06