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Erythrocyte Glutathione S-Transferase Activity as a Sensitive Marker of Kidney Function Impairment in Children with IgA Vasculitis
International Journal of Molecular Sciences, 25 (2024), 7; 3795. https://doi.org/10.3390/ijms25073795
Frković, Marijan; Turčić, Ana; Gagro, Alenka; Sršen, Saša; Huljev Frković, Sanda; Rogić, Dunja; Jelušić, Marija

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Frković, M., Turčić, A., Gagro, A., Sršen, S., Huljev Frković, S., Rogić, D. i Jelušić, M. (2024). Erythrocyte Glutathione S-Transferase Activity as a Sensitive Marker of Kidney Function Impairment in Children with IgA Vasculitis. International Journal of Molecular Sciences, 25. (7). doi: 10.3390/ijms25073795

Frković, Marijan, et al. "Erythrocyte Glutathione S-Transferase Activity as a Sensitive Marker of Kidney Function Impairment in Children with IgA Vasculitis." International Journal of Molecular Sciences, vol. 25, br. 7, 2024. https://doi.org/10.3390/ijms25073795

Frković, Marijan, Ana Turčić, Alenka Gagro, Saša Sršen, Sanda Huljev Frković, Dunja Rogić i Marija Jelušić. "Erythrocyte Glutathione S-Transferase Activity as a Sensitive Marker of Kidney Function Impairment in Children with IgA Vasculitis." International Journal of Molecular Sciences 25, br. 7 (2024). https://doi.org/10.3390/ijms25073795

Frković, M., et al. (2024) 'Erythrocyte Glutathione S-Transferase Activity as a Sensitive Marker of Kidney Function Impairment in Children with IgA Vasculitis', International Journal of Molecular Sciences, 25(7). doi: 10.3390/ijms25073795

Frković M, Turčić A, Gagro A, Sršen S, Huljev Frković S, Rogić D, i sur.. Erythrocyte Glutathione S-Transferase Activity as a Sensitive Marker of Kidney Function Impairment in Children with IgA Vasculitis. International Journal of Molecular Sciences [Internet]. 28.03.2024. [pristupljeno 12.03.2025.];25(7). doi: 10.3390/ijms25073795

M. Frković, et al., "Erythrocyte Glutathione S-Transferase Activity as a Sensitive Marker of Kidney Function Impairment in Children with IgA Vasculitis", International Journal of Molecular Sciences, vol. 25, br. 7, Ožujak 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:575421. [Citirano: 12.03.2025.]

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Naslov (engleski)Erythrocyte Glutathione S-Transferase Activity as a Sensitive Marker of Kidney Function Impairment in Children with IgA Vasculitis
AutorMarijan Frković
AutorAna Turčić
AutorAlenka Gagro
AutorSaša Sršen
AutorSanda Huljev Frković
AutorDunja Rogić
AutorMarija Jelušić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PEDIJATRIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Pedijatrija
Sažetak (engleski)
IgA vasculitis (IgAV) is the most common childhood vasculitis. The main cause of morbidity and mortality in children with IgAV is nephritis (IgAVN), but the risk of its development, severity, and chronicity remain unclear. Erythrocyte glutathione S-transferase (e-GST) activity has been previously detected as a sensitive marker of kidney function impairment in several diseases. We spectrophotometrically assessed and correlated e-GST activity between 55 IgAV patients without nephritis (IgAVwN), 42 IgAVN patients, and 52 healthy controls. At disease onset, e-GST activity was significantly higher in IgAVN patients (median (interquartile range)) (5.7 U/gHb (4.4–7.5)) than in IgAVwN patients (3.1 U/gHb (2.2–4.2); p < 0.001), and controls (3.1 U/gHb (1.9–4.2); p < 0.001). Therewithal, there were no differences between the IgAVwN patients and controls (p = 0.837). e-GST activity was also significantly higher in the IgAVN patients than in the IgAVwN patients after 3 months (5.0 U/gHb (4.2–6.2) vs. 3.3 U/gHb (2.3–4.1); p < 0.001) and 6 months (4.2 U/gHb (3.2–5.8) vs. 3.3 U/gHb (2.1–4.1); p < 0.001) since the disease onset. Consistent correlations between e-GST activity and serum creatinine, estimated glomerular filtration rate (eGFR), and proteinuria levels were not detected. In conclusion, increased e-GST activity can serve as a subtle indicator of kidney function impairment in children with IgAV.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 25, br. 7, 3795
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms25073795
URN:NBNurn:nbn:hr:105:575421
Datum objave publikacije2024-03-28
URL dokumentahttps://www.mdpi.com/1422-0067/25/7/3795
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2025-03-12 12:32:29