prikaz prve stranice dokumenta Impaired HDL antioxidant and anti-inflammatory functions are linked to increased mortality in acute heart failure patients
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Impaired HDL antioxidant and anti-inflammatory functions are linked to increased mortality in acute heart failure patients
Redox Biology, 76 (2024); 103341. https://doi.org/10.1016/j.redox.2024.103341
Pammer, Anja; Klobučar, Iva; Stadler, Julia T.; Meissl, Sabine; Habisch, Hansjörg; Madl, Tobias; Frank, Saša; Degoricija, Vesna; Marsche, Gunther

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Pammer, A., Klobučar, I., Stadler, J. T., Meissl, S., Habisch, H., Madl, T. ... Marsche, G. (2024). Impaired HDL antioxidant and anti-inflammatory functions are linked to increased mortality in acute heart failure patients. Redox Biology, 76.. doi: 10.1016/j.redox.2024.103341

Pammer, Anja, et al. "Impaired HDL antioxidant and anti-inflammatory functions are linked to increased mortality in acute heart failure patients." Redox Biology, vol. 76, 2024. https://doi.org/10.1016/j.redox.2024.103341

Pammer, Anja, Iva Klobučar, Julia T. Stadler, Sabine Meissl, Hansjörg Habisch, Tobias Madl, Saša Frank, Vesna Degoricija i Gunther Marsche. "Impaired HDL antioxidant and anti-inflammatory functions are linked to increased mortality in acute heart failure patients." Redox Biology 76 (2024). https://doi.org/10.1016/j.redox.2024.103341

Pammer, A., et al. (2024) 'Impaired HDL antioxidant and anti-inflammatory functions are linked to increased mortality in acute heart failure patients', Redox Biology, 76. doi: 10.1016/j.redox.2024.103341

Pammer A, Klobučar I, Stadler JT, Meissl S, Habisch H, Madl T, i sur.. Impaired HDL antioxidant and anti-inflammatory functions are linked to increased mortality in acute heart failure patients. Redox Biology [Internet]. 10.2024. [pristupljeno 25.04.2025.];76. doi: 10.1016/j.redox.2024.103341

A. Pammer, et al., "Impaired HDL antioxidant and anti-inflammatory functions are linked to increased mortality in acute heart failure patients", Redox Biology, vol. 76, Listopad 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:101287. [Citirano: 25.04.2025.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:101287
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Podaci o radu
Naslov (engleski)Impaired HDL antioxidant and anti-inflammatory functions are linked to increased mortality in acute heart failure patients
AutorAnja Pammer
AutorIva Klobučar
AutorJulia T. Stadler
AutorSabine Meissl
AutorHansjörg Habisch
AutorTobias Madl
AutorSaša Frank
AutorVesna Degoricija
AutorGunther Marsche
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Aims: Acute heart failure (AHF) is typified by inflammatory and oxidative stress responses, which are associated with unfavorable patient outcomes. Given the anti-inflammatory and antioxidant properties of high-density lipoprotein (HDL), this study sought to examine the relationship between impaired HDL function and mortality in AHF patients. The complex interplay between various HDL-related biomarkers and clinical outcomes remains poorly understood. Methods: HDL subclass distribution was quantified by nuclear magnetic resonance spectroscopy. Lecithin-cholesterol acyltransferase (LCAT) activity, cholesterol ester transfer protein (CETP) activity, and paraoxonase (PON-1) activity were assessed using fluorometric assays. HDL-cholesterol efflux capacity (CEC) was assessed in a validated assay using [3H]-cholesterol-labeled J774 macrophages. Results: Among the study participants, 74 (23.5 %) out of 315 died within three months after hospitalization due to AHF. These patients exhibited lower activities of the anti-oxidant enzymes PON1 and LCAT, impaired CEC, and lower concentration of small HDL subclasses, which remained significant after accounting for potential confounding factors. Smaller HDL particles, particularly HDL3 and HDL4, exhibited a strong association with CEC, PON1 activity, and LCAT activity. Conclusions: In patients with AHF, impaired HDL CEC, HDL antioxidant and anti-inflammatory function, and impaired HDL metabolism are associated with increased mortality. Assessment of HDL function and subclass distribution could provide valuable clinical information and help identify patients at high risk.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaRedox Biology
Brojčani podacivol. 76, 103341
p-ISSN2213-2317
DOIhttps://doi.org/10.1016/j.redox.2024.103341
URN:NBNurn:nbn:hr:105:101287
Datum objave publikacije2024-10
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S2213231724003197
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2025-03-24 09:15:55