Are important predictors of adverse outcome in children with symptomatic congenital cytomegalovirus infection overlooked in clinical settings?

Znanstveni rad - Izvorni znanstveni rad

• Autor: Ivana Đaković
• Autor: Ivica Kostović
• Autor: Katarina Vulin
• Autor: Iva Prvčić
• Autor: Goran Tešović
• Autor: Goran Krakar
• Autor: Tomislav Gojmerac
• Autor: Jadranka Sekelj Fureš
• Autor: Vlatka Mejaški Bošnjak
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet; (HRVATSKI INSTITUT ZA ISTRAŽIVANJE MOZGA)
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet; (KATEDRA ZA INFEKTOLOGIJU)
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Kliničke medicinske znanosti; Infektologija

Sažetak (engleski)

Objective: Congenital cytomegalovirus infection (cCMV) is a common, frequently unrecognized cause of childhood disability. The aim of the present study was to determine the symptoms that raise the suspicion of cCMV, define the neurodevelopmental outcomes, and assess their correlations.

Methods: This longitudinal observational study comprised 78 children with symptomatic cCMV who underwent neuropediatric follow-up for 4 to 17.9 years.

Results: Symptoms of central nervous system involvement, hearing/visual impairments, and hepatic involvement were mostly recognized. The average age of disease suspicion was 3.3 months. In terms of outcomes, 10.53% of the children developed complex minor neurological dysfunction and 23.68% developed cerebral palsy. Visual and hearing impairments occurred in 38.16% and 14.47% of patients, respectively. Intellectual disability was present in 30.26% of patients, and epilepsy in 21.05%. Microcephaly and hearing impairment was significantly associated with overall neurodevelopmental outcome. Microcephaly was also associated with poor motor outcomes, hearing impairment, and severe visual impairment. Furthermore, microcephaly and intrauterine growth restriction were significantly associated with poor cognitive outcomes.

Conclusion: Symptoms that raised the suspicion of cCMV-especially microcephaly, hearing impairment, and intrauterine growth restriction-were important parameters that were associated with outcomes; however, their recognition was often insufficient and/or late.

• Ključne riječi (engleski): Adolescent; Cerebral Palsy; Child; Child, Preschool; Cytomegalovirus / pathogenicity; Cytomegalovirus Infections / complications; Cytomegalovirus Infections / congenital; Cytomegalovirus Infections / diagnosis; Female; Fetal Growth Retardation / virology; Follow-Up Studies; Hearing Loss / diagnosis; Hearing Loss / etiology; Hearing Loss / virology; Humans; Infant; Infant, Newborn; Intellectual Disability / virology; Longitudinal Studies; Male; Microcephaly / etiology; Microcephaly / virology; Prognosis; Vision Disorders / diagnosis; Vision Disorders / etiology; Vision Disorders / virology
• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Izvorni znanstveni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: Journal of International Medical Research
• Brojčani podaci: vol. 52, br. 9, 3000605241274226
• p-ISSN: 0300-0605
• e-ISSN: 1473-2300
• DOI: https://doi.org/10.1177/03000605241274226
• URN:NBN: urn:nbn:hr:105:171114
• Datum objave publikacije: 2024-09-03
• URL dokumenta: https://journals.sagepub.com/doi/10.1177/03000605241274226
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2025-03-24 09:34:11