Impact of Human Papillomavirus on microRNA-21 Expression in Oral and Oropharyngeal Cancer—A Systematic Review

Znanstveni rad - Pregledni rad

• Autor: Mario Kordić
• Autor: Dinko Martinović
• Autor: Ema Puizina
• Autor: Joško Božić
• Autor: Željko Zubčić
• Autor: Emil Dediol
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet; (KATEDRA ZA MAKSILOFACIJALNU KIRURGIJU SA STOMATOLOGIJOM)
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Kliničke medicinske znanosti; Kirurgija

Sažetak (engleski)

Recently, microRNAs (miR) were identified to have potential links with oral squamous cell carcinoma (OSCC) and oropharyngeal squamous cell carcinoma (OPSCC) oncogenesis, specifically miR-21. Since HPV is a major risk factor for the development of these diseases, we aimed to search the literature regarding miR-21 expression in both HPV-positive and HPV-negative OSCC/OPSCC. The search was performed in the PubMed (MEDLINE), Scopus, Web of Science, and Cochrane electronic databases. The research question was as follows: Is there a difference in the tissue expression of miR-21 between patients with HPV-positive and those with HPV-negative OSCC/OPSCC? After conducting a meticulous search strategy, four studies were included, and they had a pooled sample size of 621 subjects with OSCC and/or OPSCC. Three studies did not find any significant difference in miR-21 expression between HPV-positive and HPV-negative OSCC/OPSCC. The findings of this systematic review showed that there are no differences in miR-21 expression between HPV-positive and HPV-negative OSCC/OPSCC. Nevertheless, it is worth noting that there are still insufficient studies regarding this important subject, because understanding how HPV influences miR-21 expression and its downstream effects can provide insights into the molecular mechanisms underlying OSCC/OPSCC development and progression.

• Ključne riječi (engleski): Carcinoma, Squamous Cell / genetics; Carcinoma, Squamous Cell / metabolism; Carcinoma, Squamous Cell / virology; Gene Expression Regulation, Neoplastic; Human Papillomavirus Viruses / genetics; Humans; MicroRNAs / genetics; MicroRNAs / metabolism; Mouth Neoplasms / genetics; Mouth Neoplasms / metabolism; Mouth Neoplasms / virology; Oropharyngeal Neoplasms / genetics; Oropharyngeal Neoplasms / metabolism; Oropharyngeal Neoplasms / virology; Papillomavirus Infections / complications; Papillomavirus Infections / genetics; Papillomavirus Infections / virology
• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Pregledni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: International Journal of Molecular Sciences
• Brojčani podaci: vol. 25, br. 15, 8038
• e-ISSN: 1422-0067
• DOI: https://doi.org/10.3390/ijms25158038
• URN:NBN: urn:nbn:hr:105:338794
• Datum objave publikacije: 2024-07-23
• URL dokumenta: https://www.mdpi.com/1422-0067/25/15/8038
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2025-03-31 08:41:25