Novel Pharmaceuticals in Appetite Regulation: Exploring emerging gut peptides and their pharmacological prospects

Znanstveni rad - Pregledni rad

• Autor: Igor Rubinić
• Autor: Marija Kurtov
• Autor: Robert Likić
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet; (KATEDRA ZA INTERNU MEDICINU)
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Kliničke medicinske znanosti; Interna medicina

Sažetak (engleski)

Obesity, a global health challenge, necessitates innovative approaches for effective management. Targeting gut peptides in the development of anti‐obesity pharmaceuticals has already demonstrated significant efficacy. Ghrelin, peptide YY (PYY), cholecystokinin (CCK), and amylin are crucial in appetite regulation offering promising targets for pharmacological interventions in obesity treatment using both peptide‐based and small molecule‐based pharmaceuticals. Ghrelin, a sole orexigenic gut peptide, has a potential for anti‐obesity therapies through various approaches, including endogenous ghrelin neutralization, ghrelin receptor antagonists, ghrelin O‐acyltransferase, and functional inhibitors. Anorexigenic gut peptides, peptide YY, cholecystokinin, and amylin, have exhibited appetite‐reducing effects in animal models and humans. Overcoming substantial obstacles is imperative for translating these findings into clinically effective pharmaceuticals. Peptide YY and cholecystokinin analogues, characterized by prolonged half‐life and resistance to proteolytic enzymes, present viable options. Positive allosteric modulators emerge as a novel approach for modulating the cholecystokinin pathway. Amylin is currently the most promising, with both amylin analogues and dual amylin and calcitonin receptor agonists (DACRAs) progressing to advanced stages of clinical trials. Despite persistent challenges, innovative pharmaceutical strategies provide a glimpse into the future of anti‐obesity therapies.

• Ključne riječi (engleski): Animals; Anti-Obesity Agents / pharmacology; Anti-Obesity Agents / therapeutic use; Appetite Depressants / pharmacology; Appetite Depressants / therapeutic use; Appetite Regulation / drug effects; Cholecystokinin / metabolism; Cholecystokinin / pharmacology; Ghrelin / pharmacology; Ghrelin / therapeutic use; Humans; Islet Amyloid Polypeptide / metabolism; Islet Amyloid Polypeptide / pharmacology; Obesity / drug therapy; Peptide YY / pharmacology; Peptide YY / therapeutic use
• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Pregledni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: Pharmacology Research & Perspectives
• Brojčani podaci: vol. 12, br. 4, e1243
• p-ISSN: 2052-1707
• e-ISSN: 2052-1707
• DOI: https://doi.org/10.1002/prp2.1243
• URN:NBN: urn:nbn:hr:105:344954
• Datum objave publikacije: 2024-07-17
• URL dokumenta: https://bpspubs.onlinelibrary.wiley.com/doi/10.1002/prp2.1243
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2025-04-08 07:02:10