prikaz prve stranice dokumenta Carvedilol to prevent hepatic decompensation of cirrhosis in patients with clinically significant portal hypertension stratified by new non-invasive model (CHESS2306)
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Carvedilol to prevent hepatic decompensation of cirrhosis in patients with clinically significant portal hypertension stratified by new non-invasive model (CHESS2306)
Clinical and Molecular Hepatology, 31 (2025), 1; 105-118. https://doi.org/10.3350/cmh.2024.0198
Liu, Chuan; You, Hong; Zeng, Qing-Lei; Wong, Yu Jun; Wang, Bingqiong; Grgurević, Ivica; Liu, Chenghai; Yim, Hyung Joon; Gou, Wei; Dong, Bingtian; Ju, Shenghong; Guo, Yanan; Yu, Qian; Hirooka, Masashi; Enomoto, Hirayuki; Hanafy, Amr Shaaban; Cao, Zhujun; Dong, Xiemin; LV, Jing; Kim, Tae Hyung; Koizumi, Yohei; Hiasa, Yoichi; Nishimura, Takashi; Iijima, Hiroko; Xu, Chuanjun; Dai, Erhei; Lan, Xiaoling; Lai, Changxiang; Liu, Shirong; Wang, Fang; Guo, Ying; Lv, Jiaojian; Zhang, Liting; Wang, Yuqing; Xie, Qing; Shao, Chuxiao; Liu, Zhensheng; Ravaioli, Federico; Colecchia, Antonio; Li, Jie; Teng, Gao-Jun; Qi, Xiaolong Više autora...

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Liu, C., You, H., Zeng, Q. L., Wong, Y. J., Wang, B., Grgurević, I. ... Qi, X. (2025). Carvedilol to prevent hepatic decompensation of cirrhosis in patients with clinically significant portal hypertension stratified by new non-invasive model (CHESS2306). Clinical and Molecular Hepatology, 31. (1), 105-118. doi: 10.3350/cmh.2024.0198

Liu, Chuan, et al. "Carvedilol to prevent hepatic decompensation of cirrhosis in patients with clinically significant portal hypertension stratified by new non-invasive model (CHESS2306)." Clinical and Molecular Hepatology, vol. 31, br. 1, 2025, str. 105-118. https://doi.org/10.3350/cmh.2024.0198

Liu, Chuan, Hong You, Qing Lei Zeng, Yu Jun Wong, Bingqiong Wang, Ivica Grgurević, Chenghai Liu, et al. "Carvedilol to prevent hepatic decompensation of cirrhosis in patients with clinically significant portal hypertension stratified by new non-invasive model (CHESS2306)." Clinical and Molecular Hepatology 31, br. 1 (2025): 105-118. https://doi.org/10.3350/cmh.2024.0198

Liu, C., et al. (2025) 'Carvedilol to prevent hepatic decompensation of cirrhosis in patients with clinically significant portal hypertension stratified by new non-invasive model (CHESS2306)', Clinical and Molecular Hepatology, 31(1), str. 105-118. doi: 10.3350/cmh.2024.0198

Liu C, You H, Zeng QL, Wong YJ, Wang B, Grgurević I, i sur.. Carvedilol to prevent hepatic decompensation of cirrhosis in patients with clinically significant portal hypertension stratified by new non-invasive model (CHESS2306). Clinical and Molecular Hepatology [Internet]. 01.2025. [pristupljeno 11.04.2025.];31(1):105-118. doi: 10.3350/cmh.2024.0198

C. Liu, et al., "Carvedilol to prevent hepatic decompensation of cirrhosis in patients with clinically significant portal hypertension stratified by new non-invasive model (CHESS2306)", Clinical and Molecular Hepatology, vol. 31, br. 1, str. 105-118, Siječanj 2025. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:262519. [Citirano: 11.04.2025.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:262519
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Naslov (engleski)Carvedilol to prevent hepatic decompensation of cirrhosis in patients with clinically significant portal hypertension stratified by new non-invasive model (CHESS2306)
AutorChuan Liu
AutorHong You
AutorQing-Lei Zeng
AutorYu Jun Wong
AutorBingqiong Wang
AutorIvica Grgurević
AutorChenghai Liu
AutorHyung Joon Yim
AutorWei Gou
AutorBingtian Dong
AutorShenghong Ju
AutorYanan Guo
AutorQian Yu
AutorMasashi Hirooka
AutorHirayuki Enomoto
AutorAmr Shaaban Hanafy
AutorZhujun Cao
AutorXiemin Dong
AutorJing LV
AutorTae Hyung Kim
AutorYohei Koizumi
AutorYoichi Hiasa
AutorTakashi Nishimura
AutorHiroko Iijima
AutorChuanjun Xu
AutorErhei Dai
AutorXiaoling Lan
AutorChangxiang Lai
AutorShirong Liu
AutorFang Wang
AutorYing Guo
AutorJiaojian Lv
AutorLiting Zhang
AutorYuqing Wang
AutorQing Xie
AutorChuxiao Shao
AutorZhensheng Liu
AutorFederico Ravaioli
AutorAntonio Colecchia
AutorJie Li
AutorGao-Jun Teng
AutorXiaolong Qi
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Backgrounds/Aims: Non-invasive models stratifying clinically significant portal hypertension (CSPH) are limited. Herein, we developed a new non-invasive model for predicting CSPH in patients with compensated cirrhosis and investigated whether carvedilol can prevent hepatic decompensation in patients with high-risk CSPH stratified using the new model. Methods: Non-invasive risk factors of CSPH were identified via systematic review and meta-analysis of studies involving patients with hepatic venous pressure gradient (HVPG). A new non-invasive model was validated for various performance aspects in three cohorts, i.e., a multicenter HVPG cohort, a follow-up cohort, and a carvediloltreating cohort. Results: In the meta-analysis with six studies (n=819), liver stiffness measurement and platelet count were identified as independent risk factors for CSPH and were used to develop the new “CSPH risk” model. In the HVPG cohort (n=151), the new model accurately predicted CSPH with cutoff values of 0 and –0.68 for ruling in and out CSPH, respectively. In the follow-up cohort (n=1,102), the cumulative incidences of decompensation events significantly differed using the cutoff values of 0 (high-risk). In the carvediloltreated cohort, patients with high-risk CSPH treated with carvedilol (n=81) had lower rates of decompensation events than non-selective beta-blockers untreated patients with high-risk CSPH (n=613 before propensity score matching [PSM], n=162 after PSM). Conclusions: Treatment with carvedilol significantly reduces the risk of hepatic decompensation in patients with high-risk CSPH stratified by the new model.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaClinical and Molecular Hepatology
Brojčani podacivol. 31, br. 1, str. 105-118
p-ISSN2287-2728
e-ISSN2287-285X
DOIhttps://doi.org/10.3350/cmh.2024.0198
URN:NBNurn:nbn:hr:105:262519
Datum objave publikacije2025-01
URL dokumentahttp://e-cmh.org/journal/view.php?doi=10.3350/cmh.2024.0198
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno 4.0 međunarodna (CC BY-NC 4.0)
Datum i vrijeme pohrane2025-04-11 08:32:47