The role of platelet tests in detection of clopidogrel hyper-response after percutaneous coronary intervention

diplomski rad

• Autor: Michael John Grašić
• Mentor: Matias Trbušić (mentor)
• Član povjerenstva: Matias Trbušić (predsjednik povjerenstva)
• Član povjerenstva: Jasenka Markeljević (član povjerenstva)
• Član povjerenstva: Vesna Degoricija (član povjerenstva)
• Ustanova koja je dodijelila akademski / stručni stupanj: Sveučilište u Zagrebu; Medicinski fakultet; Zagreb
• Datum i država obrane: 2016-09-28, Hrvatska
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Kliničke medicinske znanosti; Interna medicina

Sažetak

Clopidogrel is a PY212 antiplatelet medication which was shown to reduce mortality in patients post PCI. A percentage of the population has a resultant low platelet reactivity (LPR) or high platelet reactivity (HPR) while taking Clopidogrel. There is a connection between the LPR and increased rates of bleeding events as well as a connection between HPR and increased rates of ST events. We will examine bleeding avoidant strategies (BAS) which may be implemented to reduce bleeding event in those that are at high risk. The genetic polymorphism CYP2C19 and its association with LPR and HPR will also be looked at in more depth. Lastly, included in the discussion is the risk associated with LPR and bleeding events and HPR and ST events post PCI on clopidogrel and if these events can be accurately predicted with platelet reactivity testing before they occur. By exploring the different aspects of Clopidogrel and its resultant effects on LPR or HPR post PCI, different conclusions can be postulated on the best clinical strategies.

• Ključne riječi: platelet function tests; Clopidogrel hyper-response; percutaneous coronary intervention
• Jezik: engleski
• URN:NBN: urn:nbn:hr:105:820794
• Studijski program: Naziv: Medicina (na engleskom jeziku); Vrsta studija: sveučilišni; Stupanj studija: integrirani preddiplomski i diplomski; Akademski / stručni naziv: doktor/doktorica medicine (dr. med.)
• Vrsta resursa: Tekst
• Način izrade datoteke: Izvorno digitalna
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2017-08-25 09:38:39