prikaz prve stranice dokumenta Axon morphology of rapid Golgi-stained pyramidal neurons in the prefrontal cortex in schizophrenia
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Axon morphology of rapid Golgi-stained pyramidal neurons in the prefrontal cortex in schizophrenia
Croatian Medical Journal, 61 (2020), 4; 354-365. https://doi.org/10.3325/cmj.2020.61.354
Banovac, Ivan; Sedmak, Dora; Rojnić Kuzman, Martina; Hladnik, Ana; Petanjek, Zdravko

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Banovac, I., Sedmak, D., Rojnić Kuzman, M., Hladnik, A. i Petanjek, Z. (2020). Axon morphology of rapid Golgi-stained pyramidal neurons in the prefrontal cortex in schizophrenia. Croatian Medical Journal, 61. (4), 354-365. doi: 10.3325/cmj.2020.61.354

Banovac, Ivan, et al. "Axon morphology of rapid Golgi-stained pyramidal neurons in the prefrontal cortex in schizophrenia." Croatian Medical Journal, vol. 61, br. 4, 2020, str. 354-365. https://doi.org/10.3325/cmj.2020.61.354

Banovac, Ivan, Dora Sedmak, Martina Rojnić Kuzman, Ana Hladnik i Zdravko Petanjek. "Axon morphology of rapid Golgi-stained pyramidal neurons in the prefrontal cortex in schizophrenia." Croatian Medical Journal 61, br. 4 (2020): 354-365. https://doi.org/10.3325/cmj.2020.61.354

Banovac, I., et al. (2020) 'Axon morphology of rapid Golgi-stained pyramidal neurons in the prefrontal cortex in schizophrenia', Croatian Medical Journal, 61(4), str. 354-365. doi: 10.3325/cmj.2020.61.354

Banovac I, Sedmak D, Rojnić Kuzman M, Hladnik A, Petanjek Z. Axon morphology of rapid Golgi-stained pyramidal neurons in the prefrontal cortex in schizophrenia. Croatian Medical Journal [Internet]. 31.08.2020. [pristupljeno 20.12.2024.];61(4):354-365. doi: 10.3325/cmj.2020.61.354

I. Banovac, D. Sedmak, M. Rojnić Kuzman, A. Hladnik i Z. Petanjek, "Axon morphology of rapid Golgi-stained pyramidal neurons in the prefrontal cortex in schizophrenia", Croatian Medical Journal, vol. 61, br. 4, str. 354-365, Kolovoz 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:205152. [Citirano: 20.12.2024.]

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Podaci o radu
Naslov (engleski)Axon morphology of rapid Golgi-stained pyramidal neurons in the prefrontal cortex in schizophrenia
AutorIvan Banovac
AutorDora Sedmak
AutorMartina Rojnić Kuzman
AutorAna Hladnik
AutorZdravko Petanjek
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(HRVATSKI INSTITUT ZA ISTRAŽIVANJE MOZGA)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA ANATOMIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PSIHIJATRIJU I PSIHOLOŠKU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Neurologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Anatomija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Psihijatrija
Sažetak (engleski)
Aim To analyze axon morphology on rapid Golgi impregnated pyramidal neurons in the dorsolateral prefrontal cortex in schizophrenia. ----- Methods Postmortem brain tissue from five subjects diagnosed with schizophrenia and five control subjects without neuropathological findings was processed with the rapid Golgi method. Layer III and layer V pyramidal neurons from Brodmann area 9 were chosen in each brain for reconstruction with Neurolucida software. The axons and cell bodies of 136 neurons from subjects with schizophrenia and of 165 neurons from control subjects were traced. The data obtained by quantitative analysis were compared between the schizophrenia and control group with the t test. ----- Results Axon impregnation length was consistently greater in the schizophrenia group. The axon main trunk length was significantly greater in the schizophrenia than in the control group (93.7 ± 36.6 μm vs 49.8 ± 9.9 μm, P = 0.032). Furthermore, in the schizophrenia group more axons had visibly stained collaterals (14.7% vs 5.5%). ----- Conclusion Axon rapid Golgi impregnation stops at the beginning of the myelin sheath. The increased axonal staining in the schizophrenia group could, therefore, be explained by reduced axon myelination. Such a decrease in axon myelination is in line with both the disconnection hypothesis and the two-hit model of schizophrenia as a neurodevelopmental disease. Our results support that the cortical circuitry disorganization in schizophrenia might be caused by functional alterations of two major classes of principal neurons due to altered oligodendrocyte development.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCroatian Medical Journal
Brojčani podacivol. 61, br. 4, str. 354-365
p-ISSN0353-9504
e-ISSN1332-8166
DOIhttps://doi.org/10.3325/cmj.2020.61.354
URN:NBNurn:nbn:hr:105:205152
Datum objave publikacije2020-08-31
URL dokumentahttp://www.cmj.hr/2020/61/4/32881434.htm
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2020-10-26 12:54:24