prikaz prve stranice dokumenta Dose-volume derived nomogram as a reliable predictor of radiotherapy-induced hypothyroidism in head and neck cancer patients
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Dose-volume derived nomogram as a reliable predictor of radiotherapy-induced hypothyroidism in head and neck cancer patients
Radiology and Oncology, 53 (2019), 4; 488-496. https://doi.org/10.2478/raon-2019-0055
Prpić, Marin; Kruljac, Ivan; Kust, Davor; Suton, Petar; Purgar, Neva; Biloš, Lora Kirigin; Gregov, Marin; Mrcela, Iva; Franceschi, Maja; Đakovic, Nikola; Frobe, Ana

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Prpić, M., Kruljac, I., Kust, D., Suton, P., Purgar, N., Biloš, L. K. ... Frobe, A. (2019). Dose-volume derived nomogram as a reliable predictor of radiotherapy-induced hypothyroidism in head and neck cancer patients. Radiology and Oncology, 53. (4), 488-496. doi: 10.2478/raon-2019-0055

Prpić, Marin, et al. "Dose-volume derived nomogram as a reliable predictor of radiotherapy-induced hypothyroidism in head and neck cancer patients." Radiology and Oncology, vol. 53, br. 4, 2019, str. 488-496. https://doi.org/10.2478/raon-2019-0055

Prpić, Marin, Ivan Kruljac, Davor Kust, Petar Suton, Neva Purgar, Lora Kirigin Biloš, Marin Gregov, et al. "Dose-volume derived nomogram as a reliable predictor of radiotherapy-induced hypothyroidism in head and neck cancer patients." Radiology and Oncology 53, br. 4 (2019): 488-496. https://doi.org/10.2478/raon-2019-0055

Prpić, M., et al. (2019) 'Dose-volume derived nomogram as a reliable predictor of radiotherapy-induced hypothyroidism in head and neck cancer patients', Radiology and Oncology, 53(4), str. 488-496. doi: 10.2478/raon-2019-0055

Prpić M, Kruljac I, Kust D, Suton P, Purgar N, Biloš LK, i sur.. Dose-volume derived nomogram as a reliable predictor of radiotherapy-induced hypothyroidism in head and neck cancer patients. Radiology and Oncology [Internet]. 20.11.2019. [pristupljeno 21.12.2024.];53(4):488-496. doi: 10.2478/raon-2019-0055

M. Prpić, et al., "Dose-volume derived nomogram as a reliable predictor of radiotherapy-induced hypothyroidism in head and neck cancer patients", Radiology and Oncology, vol. 53, br. 4, str. 488-496, Studeni 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:982480. [Citirano: 21.12.2024.]

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Naslov (engleski)Dose-volume derived nomogram as a reliable predictor of radiotherapy-induced hypothyroidism in head and neck cancer patients
AutorMarin Prpić
AutorIvan Kruljac
AutorDavor Kust
AutorPetar Suton
AutorNeva Purgar
AutorLora Kirigin Biloš
AutorMarin Gregov
AutorIva Mrcela
AutorMaja Franceschi
AutorNikola Đakovic
AutorAna Frobe
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA KLINIČKU ONKOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Onkologija
Sažetak (engleski)
Background The aim of this study was to determine the possible predictive value of various dosimetric parameters on the development of hypothyroidism (HT) in patients with head and neck squamous cell carcinoma (HNSCC) treated with (chemo)radiotherapy. ----- Patients and methods This study included 156 patients with HNSCC who were treated with (chemo)radiotherapy in a primary or postoperative setting between August 2012 and September 2017. Dose-volume parameters as well as V10 toV70, D02 to D98, and the VS10 to VS70 were evaluated. The patients’ hormone status was regularly assessed during follow-up. A nomogram (score) was constructed, and the Kaplan-Maier curves and Log-Rank test were used to demonstrate the difference in incidence of HT between cut-off values of specific variables. ----- Results After a median follow-up of 23.0 (12.0–38.5) months, 70 (44.9%) patients developed HT. In univariate analysis, VS65, Dmin, V50, and total thyroid volume (TTV) had the highest accuracy in predicting HT. In a multivariate model, HT was associated with lower TTV (OR 0.31, 95% CI 0.11–0.87, P = 0.026) and Dmin (OR 9.83, 95% CI 1.89–108.08, P = 0.042). Hypothyroidism risk score (HRS) was constructed as a regression equation and comprised TTV and Dmin. HRS had an AUC of 0.709 (95% CI 0.627–0.791). HT occurred in 13 (20.0%) patients with a score < 7.1 and in 57 (62.6%) patients with a score > 7.1. ----- Conclusions The dose volume parameters VS65, Dmin, V50, and TTV had the highest accuracy in predicting HT. The HRS may be a useful tool in detecting patients with high risk for radiation-induced hypothyroidism.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaRadiology and Oncology
Brojčani podacivol. 53, br. 4, str. 488-496
e-ISSN1581-3207
DOIhttps://doi.org/10.2478/raon-2019-0055
URN:NBNurn:nbn:hr:105:982480
Datum objave publikacije2019-11-20
URL dokumentahttps://content.sciendo.com/doi/10.2478/raon-2019-0055
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 3.0 (CC BY-NC-ND 3.0)
Datum i vrijeme pohrane2020-12-08 12:48:22