Adrenergic hyperactivity: a missing link between multiple sclerosis and cardiovascular comorbidities?

Znanstveni rad - Izvorni znanstveni rad

• Autor: Mario Habek
• Autor: Tomislav Mutak
• Autor: Bojana Nevajdić
• Autor: Dunja Pucić
• Autor: Luka Crnošija
• Autor: Magdalena Krbot Skorić
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet; (KATEDRA ZA NEUROLOGIJU)
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Kliničke medicinske znanosti; Neurologija

Sažetak (engleski)

The aim of the study is to investigate differences in non-standard adrenergic baroreflex sensitivity (BRS) indices in patients with different phenotypes of multiple sclerosis (pwMS) and healthy controls (HC). Retrospective analysis of types of systolic blood pressure (BP) curves during Valsalva maneuver (VM) [balanced (BAR), augmented (AAR) and suppressed (SAR) autonomic responses] and adrenergic baroreflex sensitivity (BRSa) measured with BRSa1, α-BRSa and β-BRSa in patients with clinically isolated syndrome (CIS), relapsing remitting multiple sclerosis (RRMS), progressive multiple sclerosis (PMS) and HC. We also investigated correlations between BRSa1, α-BRSa, β-BRSa and resting catecholamine levels. pwMS had higher α-BRSa compared to HC (p = 0.02). There was no difference in BRSa1, s and β-BRSa between patients with CIS, RRMS and PMS. There was no association between pwMS and HC, and the type of sBP curve [χ2 = 4.332, p = 0.114]. pwMS and BAR or AAR had higher supine systolic and diastolic BP compared to pwMS and SAR. There was a significant correlation between α-BRSa and upright systolic BP (rp =0.194, p = 0.017), α-BRSa and norepinephrine (rs =0.228, p = 0.021), and BRSa1 and epinephrine (rs = 0.226, p = 0.040). pwMS and HC exhibit different alpha-adrenergic response to Valsalva maneuver. These results may explain the connection between MS and increased cardiovascular risk.

• Ključne riječi (engleski): Adrenergic baroreflex sensitivity; Cardiovascular autonomic dysfunction; Multiple sclerosis; Valsalva maneuver
• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Izvorni znanstveni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran
• Verzija publikacije: Završna verzija rukopisa prihvaćena za objavljivanje (postprint)
• Naslov časopisa: Acta Neurologica Belgica
• Brojčani podaci: vol. 120, br. 3, str. 581-587
• p-ISSN: 0300-9009
• e-ISSN: 2240-2993
• DOI: https://doi.org/10.1007/s13760-018-1051-4
• URN:NBN: urn:nbn:hr:105:377935
• Datum objave publikacije: 2020-06
• URL dokumenta: http://link.springer.com/10.1007/s13760-018-1051-4
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup; Datum isteka embarga: 2021-06-30
• Datum i vrijeme pohrane: 2021-01-14 09:36:00