The epidemiological and clinical features of odontogenic infective endocarditis

Znanstveni rad - Izvorni znanstveni rad

• Autor: Ivana Šutej
• Autor: Kristina Peroš
• Autor: Vladimir Trkulja
• Autor: Igor Rudež
• Autor: Davor Barić
• Autor: Ivan Alajbeg
• Autor: Hrvoje Pintarić
• Autor: Ranko Stevanović
• Autor: Dragan Lepur
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet; (KATEDRA ZA TEMELJNU I KLINIČKU FARMAKOLOGIJU)
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet; (KATEDRA ZA KIRURGIJU)
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Kliničke medicinske znanosti; Kirurgija
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Temeljne medicinske znanosti; Farmakologija

Sažetak (engleski)

Antibiotic prophylaxis (AP) of infective endocarditis (IE) in dental practice is a controversial topic. We evaluated the characteristics of the odontogenic IE and assessed the practice and sources of information pertaining to the topic utilized by the Croatian dentists. We conducted a retrospective review of consecutive medical charts of adult patients with IE, admitted to the University Hospital for Infectious Diseases in Zagreb, Croatia, between January 2007 and December 2017. In addition, a cross-sectional, self-reporting questionnaire survey was conducted with participation of 348 Croatian dentists. Of the 811 admissions for suspected IE (40.3% of all Croatian and 92.1% of all Zagreb hospitals), 386 patients were confirmed as definite IE: 68 with odontogenic IE and 318 with IE of other origin. Their first hospital admissions were analyzed. Definite odontogenic IE was defined as a positive echocardiographic result in conjunction with two separate positive blood cultures showing exclusive oral cavity pathogen or Streptococcus viridans associated with current or recent (< 1 month) dental, periodontal, or oral cavity infection. The annual number of new odontogenic IE patients appeared constant over time. In 91.2% of the cases, odontogenic IE was not preceded by a dental procedure; poor oral health was found in 51.5% of patients, and 47.1% had no cardiac condition that increases the IE risk. In-hospital mortality was 5.1% with conservative treatment and 4.5% with cardiac surgery and was much lower for odontogenic IE than in non-odontogenic IE (14.6% and 34.4%, respectively). An increasing number of admissions for non-odontogenic IE were observed in parallel with an increasing number of staphylococcal IE. Surveyed dentists (500 invited, 69.6% responded) were aware of the AP recommendations, but were largely reluctant to treat patients at risk. In people with poor oral health, AP should be considered regardless of cardiac risk factors. Improvement of oral health should be the cornerstone of odontogenic IE prevention.

• Ključne riječi (engleski): Aged; Antibiotic Prophylaxis; Croatia / epidemiology; Cross-Sectional Studies; Dental Care / adverse effects; Endocarditis / epidemiology; Endocarditis / etiology; Endocarditis / prevention & control; Female; Hospitals, University; Humans; Male; Middle Aged; Odontogenesis; Retrospective Studies; Risk Factors; Streptococcal Infections / complications; Streptococcal Infections / epidemiology; Streptococcal Infections / etiology; Surveys and Questionnaires; Viridans Streptococci / isolation & purification; Viridans Streptococci / pathogenicity
• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Izvorni znanstveni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran
• Verzija publikacije: Završna verzija rukopisa prihvaćena za objavljivanje (postprint)
• Naslov časopisa: European Journal of Clinical Microbiology & Infectious Diseases
• Brojčani podaci: vol. 39, br. 4, str. 637-645
• p-ISSN: 0934-9723
• e-ISSN: 1435-4373
• DOI: https://doi.org/10.1007/s10096-019-03766-x
• URN:NBN: urn:nbn:hr:105:749746
• Datum objave publikacije: 2020-04
• URL dokumenta: http://link.springer.com/10.1007/s10096-019-03766-x
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup; Datum isteka embarga: 2021-04-30
• Datum i vrijeme pohrane: 2021-01-14 11:13:31