prikaz prve stranice dokumenta Prognostic significance of bone morphogenetic protein 6 (BMP6) expression, clinical and pathological factors in clinically node-negative oral squamous cell carcinoma (OSCC)
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Prognostic significance of bone morphogenetic protein 6 (BMP6) expression, clinical and pathological factors in clinically node-negative oral squamous cell carcinoma (OSCC)
Journal of Cranio-Maxillofacial Surgery, 47 (2019), 1; 80-86. https://doi.org/10.1016/j.jcms.2018.10.003
Suton, Petar; Bolanča, Ante; Grgurević, Lovorka; Erjavec, Igor; Nikles, Iva; Muller, Danko; Manojlović, Spomenka; Vukičević, Slobodan; Petrovečki, Mladen; Dokuzović, Stjepan; Lukšić, Ivica

Citirajte ovaj rad

Suton, P., Bolanča, A., Grgurević, L., Erjavec, I., Nikles, I., Muller, D. ... Lukšić, I. (2019). Prognostic significance of bone morphogenetic protein 6 (BMP6) expression, clinical and pathological factors in clinically node-negative oral squamous cell carcinoma (OSCC). Journal of Cranio-Maxillofacial Surgery, 47. (1), 80-86. doi: 10.1016/j.jcms.2018.10.003

Suton, Petar, et al. "Prognostic significance of bone morphogenetic protein 6 (BMP6) expression, clinical and pathological factors in clinically node-negative oral squamous cell carcinoma (OSCC)." Journal of Cranio-Maxillofacial Surgery, vol. 47, br. 1, 2019, str. 80-86. https://doi.org/10.1016/j.jcms.2018.10.003

Suton, Petar, Ante Bolanča, Lovorka Grgurević, Igor Erjavec, Iva Nikles, Danko Muller, Spomenka Manojlović, et al. "Prognostic significance of bone morphogenetic protein 6 (BMP6) expression, clinical and pathological factors in clinically node-negative oral squamous cell carcinoma (OSCC)." Journal of Cranio-Maxillofacial Surgery 47, br. 1 (2019): 80-86. https://doi.org/10.1016/j.jcms.2018.10.003

Suton, P., et al. (2019) 'Prognostic significance of bone morphogenetic protein 6 (BMP6) expression, clinical and pathological factors in clinically node-negative oral squamous cell carcinoma (OSCC)', Journal of Cranio-Maxillofacial Surgery, 47(1), str. 80-86. doi: 10.1016/j.jcms.2018.10.003

Suton P, Bolanča A, Grgurević L, Erjavec I, Nikles I, Muller D, i sur.. Prognostic significance of bone morphogenetic protein 6 (BMP6) expression, clinical and pathological factors in clinically node-negative oral squamous cell carcinoma (OSCC). Journal of Cranio-Maxillofacial Surgery [Internet]. 01.2019. [pristupljeno 24.10.2024.];47(1):80-86. doi: 10.1016/j.jcms.2018.10.003

P. Suton, et al., "Prognostic significance of bone morphogenetic protein 6 (BMP6) expression, clinical and pathological factors in clinically node-negative oral squamous cell carcinoma (OSCC)", Journal of Cranio-Maxillofacial Surgery, vol. 47, br. 1, str. 80-86, Siječanj 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:792561. [Citirano: 24.10.2024.]

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Naslov (engleski)Prognostic significance of bone morphogenetic protein 6 (BMP6) expression, clinical and pathological factors in clinically node-negative oral squamous cell carcinoma (OSCC)
AutorPetar Suton
AutorAnte Bolanča
AutorLovorka Grgurević
AutorIgor Erjavec
AutorIva Nikles
AutorDanko Muller
AutorSpomenka Manojlović
AutorSlobodan Vukičević
AutorMladen Petrovečki
AutorStjepan Dokuzović
AutorIvica Lukšić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA MAKSILOFACIJALNU KIRURGIJU SA STOMATOLOGIJOM)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Kirurgija
Sažetak (engleski)
Bone morphogenetic protein 6 (BMP6) has unique properties regarding structure and function in supporting bone formation during development and adult life. Despite its known role in various malignant tumors, the prognostic significance of BMP6 expression in oral squamous cell carcinoma (OSCC) remains unknown. The aim of the study was to investigate immunohistochemical expression of BMP6 in OSCC in correlation with clinical and pathological parameters, disease recurrence and survival. In addition, we investigated other parameters in order to identify prognosticators of neck metastases and final outcome. The study included 120 patients with clinically T1-3N0 OSCC who were primarily surgically treated between 2003 and 2008. There were 99 (82.5%) male and 21 (17.5%) female patients. The five-year disease-specific survival for the whole cohort was 79.7%. Tumors smaller than 2 cm in diameter showed higher incidence of strong BMP6 expression. No statistical correlation was observed between other clinico-pathological factors and BMP6 expression. Expression of BMP6 was not associated with disease recurrence and survival. BMP6 may not serve as prognosticator of final outcome or recurrence in clinically node-negative OSCC subjects. In multivariate analysis predictors of poorer survival were positive surgical margin, moderate tumor cell differentiation and pathological involvement of levels IV and/or V.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaJournal of Cranio-Maxillofacial Surgery
Brojčani podacivol. 47, br. 1, str. 80-86
p-ISSN1010-5182
e-ISSN1878-4119
DOIhttps://doi.org/10.1016/j.jcms.2018.10.003
URN:NBNurn:nbn:hr:105:792561
Datum objave publikacije2019-01
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S1010518218308485
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2021-02-08 11:09:12