Role of Microglial Cells in Alzheimer’s Disease Tau Propagation

Znanstveni rad - Izvorni znanstveni rad

• Autor: Ena Španić
• Autor: Lea Langer Horvat
• Autor: Patrick R. Hof
• Autor: Goran Šimić
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet; (HRVATSKI INSTITUT ZA ISTRAŽIVANJE MOZGA)
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet; (KATEDRA ZA ANATOMIJU)
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Temeljne medicinske znanosti; Anatomija
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Temeljne medicinske znanosti; Neuroznanost

Sažetak (engleski)

Uncontrolled immune response in the brain contributes to the progression of all neurodegenerative disease, including Alzheimer's disease (AD). Recent investigations have documented the prion-like features of tau protein and the involvement of microglial changes with tau pathology. While it is still unclear what sequence of events is causal, it is likely that tau seeding potential and microglial contribution to tau propagation act together, and are essential for the development and progression of degenerative changes. Based on available evidence, targeting tau seeds and controlling some signaling pathways in a complex inflammation process could represent a possible new therapeutic approach for treating neurodegenerative diseases. Recent findings propose novel diagnostic assays and markers that may be used together with standard methods to complete and improve the diagnosis and classification of these diseases. In conclusion, a novel perspective on microglia-tau relations reveals new issues to investigate and imposes different approaches for developing therapeutic strategies for AD.

• Ključne riječi (engleski): Alzheimer’s disease; blood-brain barrier; inflammation; microglia; neurodegeneration; tau protein propagation
• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Izvorni znanstveni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: Frontiers in Aging Neuroscience
• Brojčani podaci: vol. 11, 271
• e-ISSN: 1663-4365
• DOI: https://doi.org/10.3389/fnagi.2019.00271
• URN:NBN: urn:nbn:hr:105:437965
• Datum objave publikacije: 2019-10-04
• Projekt: Šifra: IP-2014-09-9730; Naziv (hrvatski): Hiperfosforilacija, agregacija i transsinaptički prijenos tau proteina u Alzheimerovoj bolesti: analiza likvora i ispitivanje potencijalnih neuroprotektivnih spojeva; Naziv (engleski): Tau protein hyperphosphorylation, aggregation and trans-synaptic transfer in Alzheimer's disease: cerebrospinal fluid analysis and assessment of potential neuroprotective compounds; Kratica: ALZTAUPROTECT; Pravna nadležnost: Hrvatska; Financijer: HRZZ; Linija financiranja: IP
• URL dokumenta: https://www.frontiersin.org/article/10.3389/fnagi.2019.00271/full
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2021-03-01 10:18:41