Epidemiology of 10-year paediatric renal biopsies in the region of southern Croatia

Znanstveni rad - Izvorni znanstveni rad

• Autor: Adela Arapović
• Autor: Katarina Vukojević
• Autor: Natalija Filipović
• Autor: Merica Glavina Durdov
• Autor: Danica Ljubanović-Galešić
• Autor: Mirna Saraga-Babić
• Autor: Sandra Prgomet
• Autor: Ana Simičić Majce
• Autor: Anja Belavić
• Autor: Dijana Borić Škaro
• Autor: Dragan Ljutić
• Autor: Marijan Saraga
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet; (KATEDRA ZA PATOLOGIJU)
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Kliničke medicinske znanosti; Patologija

Sažetak (engleski)

Background: Information about renal diseases in children is available from national registries of renal biopsies. Aim of the study was to compare the clinical presentation of glomerular diseases and tubulointerstitial space diseases with pathohistological diagnosis of indicated renal biopsies from pediatric population in the Croatian region of Dalmatia.
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Methods: Out of 231 pediatric patients with suspected glomerular and tubulointerstitial diseases, 54 underwent ultrasound-guided renal biopsy at University Hospital of Split. Kidney allograft biopsy, and re-biopsy were excluded. The biopsy sections were examined under light microscopy, immunofluorescence and electron microscopy. The data was reviewed to determine the pathohistological spectrum and clinicopathologic correlations. We retrospectively analyzed kidney biopsy data from 2008 to 2017 and compared them to that between 1995 and 2005.
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Results: The mean age of patients was 9.84 ± 5.4 years. Male:female ratio was 1.2:1. The main indications for biopsy were pure nephrotic syndrome without hematuria (25.9%), non-nephrotic proteinuria with haematuria (22.2%), nephritic syndrome with nephrotic proteinuria (18.5%), and isolated hematuria (16.7%). The most common pathohistological findings were IgA nephropathy (IgAN, 24.1%), minimal change disease (MCD, 16.7%), Henoch-Schönlein purpura glomerulonephritis (HSPN, 14.8%), Alport syndrome and focal segmental glomerulosclerosis (AS and FSGS, 11.1% each), tubulointerstitial nephritis and membranous glomerulopathy (TIN and MGN, 3.7% each), while other cases were diagnosed rarely.
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Conclusions: Changes in epidemiology of renal diseases in children between the analyzed periods showed an increasing trend of IgAN, MCD, HSPN, AS and FSGS, while mesangioproliferative glomerulonephritis (MesPGN) and endoproliferative glomerulonephritis (EDGN) showed a decreasing trend that can be explained with the new pathohistological classification.

• Ključne riječi (engleski): Epidemiology; Nephrotic syndrome; Registries; Renal biopsy
• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Izvorni znanstveni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: BMC Nephrology
• Brojčani podaci: vol. 21, br. 1, 65
• e-ISSN: 1471-2369
• DOI: https://doi.org/10.1186/s12882-020-01727-7
• URN:NBN: urn:nbn:hr:105:423055
• Datum objave publikacije: 2020-02-26
• URL dokumenta: https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-020-01727-7
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2021-03-22 10:55:53