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HTR1A, HTR1B, HTR2A, HTR2C and HTR6 Gene Polymorphisms and Extrapyramidal Side Effects in Haloperidol-Treated Patients with Schizophrenia
International Journal of Molecular Sciences, 21 (2020), 7; 2345. https://doi.org/10.3390/ijms21072345
Grubor, Mirko; Živković, Maja; Šagud, Marina; Nikolac Perković, Matea; Mihaljević-Peleš, Alma; Pivac, Nela; Muck-Šeler, Dorotea; Švob Štrac, Dubravka

Citirajte ovaj rad

Grubor, M., Živković, M., Šagud, M., Nikolac Perković, M., Mihaljević Peleš, A., Pivac, N. ... Švob Štrac, D. (2020). HTR1A, HTR1B, HTR2A, HTR2C and HTR6 Gene Polymorphisms and Extrapyramidal Side Effects in Haloperidol-Treated Patients with Schizophrenia. International Journal of Molecular Sciences, 21. (7). doi: 10.3390/ijms21072345

Grubor, Mirko, et al. "HTR1A, HTR1B, HTR2A, HTR2C and HTR6 Gene Polymorphisms and Extrapyramidal Side Effects in Haloperidol-Treated Patients with Schizophrenia." International Journal of Molecular Sciences, vol. 21, br. 7, 2020. https://doi.org/10.3390/ijms21072345

Grubor, Mirko, Maja Živković, Marina Šagud, Matea Nikolac Perković, Alma Mihaljević Peleš, Nela Pivac, Dorotea Muck Šeler i Dubravka Švob Štrac. "HTR1A, HTR1B, HTR2A, HTR2C and HTR6 Gene Polymorphisms and Extrapyramidal Side Effects in Haloperidol-Treated Patients with Schizophrenia." International Journal of Molecular Sciences 21, br. 7 (2020). https://doi.org/10.3390/ijms21072345

Grubor, M., et al. (2020) 'HTR1A, HTR1B, HTR2A, HTR2C and HTR6 Gene Polymorphisms and Extrapyramidal Side Effects in Haloperidol-Treated Patients with Schizophrenia', International Journal of Molecular Sciences, 21(7). doi: 10.3390/ijms21072345

Grubor M, Živković M, Šagud M, Nikolac Perković M, Mihaljević Peleš A, Pivac N, i sur.. HTR1A, HTR1B, HTR2A, HTR2C and HTR6 Gene Polymorphisms and Extrapyramidal Side Effects in Haloperidol-Treated Patients with Schizophrenia. International Journal of Molecular Sciences [Internet]. 28.03.2020. [pristupljeno 20.12.2024.];21(7). doi: 10.3390/ijms21072345

M. Grubor, et al., "HTR1A, HTR1B, HTR2A, HTR2C and HTR6 Gene Polymorphisms and Extrapyramidal Side Effects in Haloperidol-Treated Patients with Schizophrenia", International Journal of Molecular Sciences, vol. 21, br. 7, Ožujak 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:380748. [Citirano: 20.12.2024.]

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Naslov (engleski)HTR1A, HTR1B, HTR2A, HTR2C and HTR6 Gene Polymorphisms and Extrapyramidal Side Effects in Haloperidol-Treated Patients with Schizophrenia
AutorMirko Grubor
AutorMaja Živković
AutorMarina Šagud
AutorMatea Nikolac Perković
AutorAlma Mihaljević-Peleš
AutorNela Pivac
AutorDorotea Muck-Šeler
AutorDubravka Švob Štrac
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PSIHIJATRIJU I PSIHOLOŠKU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Psihijatrija
Sažetak (engleski)
Schizophrenia is a serious, chronic psychiatric disorder requiring lifelong treatment. Extrapyramidal side effects (EPS) are common adverse reactions to antipsychotic medications. In addition to the dopaminergic system, serotonergic mechanisms, including serotonin (5-HT) receptors, might be involved in EPS development. This study aimed to examine molecular associations of HTR1A, HTR1B, HTR2A, HTR2C and HTR6 gene polymorphisms with acute EPS in 229 male schizophrenia patients, following two weeks of haloperidol monotherapy. The Simpson–Angus Rating Scale for Extrapyramidal Side Effects (SAS), Barnes Akathisia Rating Scale (BARS) and Extrapyramidal Symptom Rating Scale (ESRS) were used to evaluate EPS severity. Genotyping was performed using real-time PCR, following extraction of blood DNA. Significant acute EPS appeared in 48.03% of schizophrenia patients. For the rs13212041 HTR1B gene polymorphism, affecting microRNA regulation of HTR1B gene expression, a higher frequency of TT carriers was found among haloperidol-treated patients with akathisia when compared to the group without akathisia symptoms. In comparison to C-allele carriers, patients carrying the TT genotype had higher akathisia severity, as determined by the SAS, BARS and ESRS scales. These molecular findings suggest potential involvement of 5-HT1B receptors in akathisia development following haloperidol treatment, as well as possible epigenetic mechanisms of serotonergic modulation associated with antipsychotic-induced EPS.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 21, br. 7, 2345
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms21072345
URN:NBNurn:nbn:hr:105:380748
Datum objave publikacije2020-03-28
URL dokumentahttps://www.mdpi.com/1422-0067/21/7/2345
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2021-04-19 11:50:09