prikaz prve stranice dokumenta Effect of vortioxetine vs. escitalopram on plasma BDNF and platelet serotonin in depressed patients
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Effect of vortioxetine vs. escitalopram on plasma BDNF and platelet serotonin in depressed patients
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 105 (2021); 110016. https://doi.org/10.1016/j.pnpbp.2020.110016
Dvojković, Anja; Nikolac Perković, Matea; Šagud, Marina; Nedić Erjavec, Gordana; Mihaljević Peleš, Alma; Švob Štrac, Dubravka; Vuksan Ćusa, Bjanka; Tudor, Lucija; Kušević, Zorana; Konjevod, Marcela; Živković, Maja; Jevtović, Saša; Pivac, Nela

Citirajte ovaj rad

Dvojković, A., Nikolac Perković, M., Šagud, M., Nedić Erjavec, G., Mihaljević Peleš, A., Švob Štrac, D. ... Pivac, N. (2021). Effect of vortioxetine vs. escitalopram on plasma BDNF and platelet serotonin in depressed patients. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 105.. doi: 10.1016/j.pnpbp.2020.110016

Dvojković, Anja, et al. "Effect of vortioxetine vs. escitalopram on plasma BDNF and platelet serotonin in depressed patients." Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 105, 2021. https://doi.org/10.1016/j.pnpbp.2020.110016

Dvojković, Anja, Matea Nikolac Perković, Marina Šagud, Gordana Nedić Erjavec, Alma Mihaljević Peleš, Dubravka Švob Štrac, Bjanka Vuksan Ćusa, et al. "Effect of vortioxetine vs. escitalopram on plasma BDNF and platelet serotonin in depressed patients." Progress in Neuro-Psychopharmacology and Biological Psychiatry 105 (2021). https://doi.org/10.1016/j.pnpbp.2020.110016

Dvojković, A., et al. (2021) 'Effect of vortioxetine vs. escitalopram on plasma BDNF and platelet serotonin in depressed patients', Progress in Neuro-Psychopharmacology and Biological Psychiatry, 105. doi: 10.1016/j.pnpbp.2020.110016

Dvojković A, Nikolac Perković M, Šagud M, Nedić Erjavec G, Mihaljević Peleš A, Švob Štrac D, i sur.. Effect of vortioxetine vs. escitalopram on plasma BDNF and platelet serotonin in depressed patients. Progress in Neuro-Psychopharmacology and Biological Psychiatry [Internet]. 08.03.2021. [pristupljeno 14.04.2024.];105. doi: 10.1016/j.pnpbp.2020.110016

A. Dvojković, et al., "Effect of vortioxetine vs. escitalopram on plasma BDNF and platelet serotonin in depressed patients", Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 105, Ožujak 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:222295. [Citirano: 14.04.2024.]

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Naslov (engleski)Effect of vortioxetine vs. escitalopram on plasma BDNF and platelet serotonin in depressed patients
AutorAnja Dvojković
AutorMatea Nikolac Perković
AutorMarina Šagud
AutorGordana Nedić Erjavec
AutorAlma Mihaljević Peleš
AutorDubravka Švob Štrac
AutorBjanka Vuksan Ćusa
AutorLucija Tudor
AutorZorana Kušević
AutorMarcela Konjevod
AutorMaja Živković
AutorSaša Jevtović
AutorNela Pivac
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PSIHIJATRIJU I PSIHOLOŠKU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Psihijatrija
Sažetak (engleski)
Escitalopram and vortioxetine are efficacious antidepressants. They directly target serotonin (5-HT) system, but vortioxetine mechanism of action is distinct from the one of selective serotonin reuptake inhibitors (SSRIs). Treatment with SSRIs decrease platelet 5-HT concentration and increase peripheral brain-derived neurotrophic factor (BDNF) levels. Since vortioxetine has a multimodal mechanism of action, it is expected to have a greater effect on circulatory BDNF concentration, compared to conventional antidepressants. This longitudinal study aimed to explore and compare the effects of 4-weeks of treatment with vortioxetine and escitalopram on plasma BDNF and platelet 5-HT concentration in patients with major depressive disorder (MDD). The results revealed that vortioxetine significantly increased plasma BDNF concentration (p = .018) and significantly decreased platelet 5-HT concentration (p < .001). Treatment with escitalopram significantly decreased platelet 5-HT concentration (p < .001), but it did not affect plasma BDNF concentration (p = .379). Response to vortioxetine was not predicted by baseline plasma BDNF or platelet 5-HT concentration, but response to escitalopram was predicted by baseline platelet 5-HT concentration. These effects might be due to vortioxetine unique mechanism of action, but the clinical implications are unclear. It remains to be determined whether this finding extends during long-term vortioxetine treatment, and which, if any, clinical effects emerge from BDNF increase.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaProgress in Neuro-Psychopharmacology and Biological Psychiatry
Brojčani podacivol. 105, 110016
p-ISSN0278-5846
e-ISSN1878-4216
DOIhttps://doi.org/10.1016/j.pnpbp.2020.110016
URN:NBNurn:nbn:hr:105:222295
Datum objave publikacije2021-03-08
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S0278584620303328
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Datum isteka embarga: 2022-04-30
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2021-04-20 10:32:07