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IL-1β, IL-6, IL-10, and TNFα Single Nucleotide Polymorphisms in Human Influence the Susceptibility to Alzheimer’s Disease Pathology
Journal of Alzheimer's Disease, 75 (2020), 3; 1029-1047. https://doi.org/10.3233/JAD-200056
Babić Leko, Mirjana; Nikolac Perković, Matea; Klepac, Nataša; Švob Štrac, Dubravka; Borovečki, Fran; Pivac, Nela; Hof, Patrick R.; Šimić, Goran

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Babić Leko, M., Nikolac Perković, M., Klepac, N., Švob Štrac, D., Borovečki, F., Pivac, N. ... Šimić, G. (2020). IL-1β, IL-6, IL-10, and TNFα Single Nucleotide Polymorphisms in Human Influence the Susceptibility to Alzheimer’s Disease Pathology. Journal of Alzheimer's Disease, 75. (3), 1029-1047. doi: 10.3233/JAD-200056

Babić Leko, Mirjana, et al. "IL-1β, IL-6, IL-10, and TNFα Single Nucleotide Polymorphisms in Human Influence the Susceptibility to Alzheimer’s Disease Pathology." Journal of Alzheimer's Disease, vol. 75, br. 3, 2020, str. 1029-1047. https://doi.org/10.3233/JAD-200056

Babić Leko, Mirjana, Matea Nikolac Perković, Nataša Klepac, Dubravka Švob Štrac, Fran Borovečki, Nela Pivac, Patrick R. Hof i Goran Šimić. "IL-1β, IL-6, IL-10, and TNFα Single Nucleotide Polymorphisms in Human Influence the Susceptibility to Alzheimer’s Disease Pathology." Journal of Alzheimer's Disease 75, br. 3 (2020): 1029-1047. https://doi.org/10.3233/JAD-200056

Babić Leko, M., et al. (2020) 'IL-1β, IL-6, IL-10, and TNFα Single Nucleotide Polymorphisms in Human Influence the Susceptibility to Alzheimer’s Disease Pathology', Journal of Alzheimer's Disease, 75(3), str. 1029-1047. doi: 10.3233/JAD-200056

Babić Leko M, Nikolac Perković M, Klepac N, Švob Štrac D, Borovečki F, Pivac N, i sur.. IL-1β, IL-6, IL-10, and TNFα Single Nucleotide Polymorphisms in Human Influence the Susceptibility to Alzheimer’s Disease Pathology. Journal of Alzheimer's Disease [Internet]. 02.06.2020. [pristupljeno 12.11.2024.];75(3):1029-1047. doi: 10.3233/JAD-200056

M. Babić Leko, et al., "IL-1β, IL-6, IL-10, and TNFα Single Nucleotide Polymorphisms in Human Influence the Susceptibility to Alzheimer’s Disease Pathology", Journal of Alzheimer's Disease, vol. 75, br. 3, str. 1029-1047, Lipanj 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:478592. [Citirano: 12.11.2024.]

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Podaci o radu
Naslov (engleski)IL-1β, IL-6, IL-10, and TNFα Single Nucleotide Polymorphisms in Human Influence the Susceptibility to Alzheimer’s Disease Pathology
AutorMirjana Babić Leko
AutorMatea Nikolac Perković
AutorNataša Klepac
AutorDubravka Švob Štrac
AutorFran Borovečki
AutorNela Pivac
AutorPatrick R. Hof
AutorGoran Šimić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(HRVATSKI INSTITUT ZA ISTRAŽIVANJE MOZGA)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA NEUROLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Neurologija
Sažetak (engleski)
Background: Neuroinflammation plays an important role in Alzheimer's disease (AD). During this process, activated microglia release pro-inflammatory cytokines such as interleukin (IL)-1α, IL-1β, IL-6, and tumor necrosis factor α (TNFα) that participate in neuron damage, but also anti-inflammatory cytokines (such as IL-10), which maintain homeostasis of immune response. Previous studies showed the association of IL-1α -889C/T (rs1800587), IL-1β-1473G/C (rs1143623), IL-6 -174C/G (rs1800795), IL-10 -1082G/A (rs1800896), and TNFα -308A/G (rs1800629) polymorphisms with AD. ----- Objective: We aimed to investigate whether people with certain IL-1α, IL-1β, IL-6, IL-10, and TNFα genotypes in these polymorphisms are more prone to develop AD-related pathology, reflected by pathological levels of cerebrospinal fluid (CSF) AD biomarkers including amyloid-β1-42, total tau (t-tau), tau phosphorylated at Thr 181 (p-tau181), Ser 199 (p-tau199), and Thr 231 (p-tau231), and visinin-like protein 1 (VILIP-1). ----- Methods: The study included 115 AD patients, 53 patients with mild cognitive impairment, and 11 healthy controls. The polymorphisms were determined using real-time polymerase chain reaction. Levels of CSF biomarkers were determined by enzyme-linked immunosorbent assay. ----- Results: A significant increase in p-tau CSF levels was found in patients with the AA IL-10 -1082G/A and GG TNFα -308A/G genotypes, and in carriers of a G allele in IL-1β -1473C/G and IL-6 -174C/G polymorphisms. t-tau levels were increased in carriers of a G allele in IL-1β -1473C/G polymorphism. An increase in VILIP-1 levels was observed in patients with CG and GG IL-1β -1473C/G, GC IL-6 -174C/G, and GG TNFα -308A/G genotype. ----- Conclusion: These results suggest that persons carrying certain genotypes in IL10 (-1082G/A), IL1β (1473C/G), IL6 (-174C/G), and TNFIα (-308A/G) could be more vulnerable to development of neuroinflammation, and consequently of AD.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaJournal of Alzheimer's Disease
Brojčani podacivol. 75, br. 3, str. 1029-1047
p-ISSN1387-2877
e-ISSN1875-8908
DOIhttps://doi.org/10.3233/JAD-200056
URN:NBNurn:nbn:hr:105:478592
Datum objave publikacije2020-06-02
URL dokumentahttps://www.medra.org/servlet/aliasResolver?alias=iospress&doi=10.3233/JAD-200056
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Datum isteka embarga: 2021-07-01
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2021-04-21 11:08:25