prikaz prve stranice dokumenta The Association between TNF-alpha, IL-1 alpha and IL-10 with Alzheimer's Disease
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The Association between TNF-alpha, IL-1 alpha and IL-10 with Alzheimer's Disease
Current Alzheimer Research, 17 (2021), 11; 972-984. https://doi.org/10.2174/1567205017666201130092427
Čuljak, Marija; Nikolac Perković, Matea; Uzun, Suzana; Švob Štrac, Dubravka; Nedić Erjavec, Gordana; Babić Leko, Mirjana; Šimić, Goran; Tudor, Lucija; Konjevod, Marcela; Kozumplik, Oliver; Mimica, Ninoslav; Pivac, Nela

Citirajte ovaj rad

Čuljak, M., Nikolac Perković, M., Uzun, S., Švob Štrac, D., Nedić Erjavec, G., Babić Leko, M. ... Pivac, N. (2021). The Association between TNF-alpha, IL-1 alpha and IL-10 with Alzheimer's Disease. Current Alzheimer Research, 17. (11), 972-984. doi: 10.2174/1567205017666201130092427

Čuljak, Marija, et al. "The Association between TNF-alpha, IL-1 alpha and IL-10 with Alzheimer's Disease." Current Alzheimer Research, vol. 17, br. 11, 2021, str. 972-984. https://doi.org/10.2174/1567205017666201130092427

Čuljak, Marija, Matea Nikolac Perković, Suzana Uzun, Dubravka Švob Štrac, Gordana Nedić Erjavec, Mirjana Babić Leko, Goran Šimić, et al. "The Association between TNF-alpha, IL-1 alpha and IL-10 with Alzheimer's Disease." Current Alzheimer Research 17, br. 11 (2021): 972-984. https://doi.org/10.2174/1567205017666201130092427

Čuljak, M., et al. (2021) 'The Association between TNF-alpha, IL-1 alpha and IL-10 with Alzheimer's Disease', Current Alzheimer Research, 17(11), str. 972-984. doi: 10.2174/1567205017666201130092427

Čuljak M, Nikolac Perković M, Uzun S, Švob Štrac D, Nedić Erjavec G, Babić Leko M, i sur.. The Association between TNF-alpha, IL-1 alpha and IL-10 with Alzheimer's Disease. Current Alzheimer Research [Internet]. 21.01.2021. [pristupljeno 07.11.2024.];17(11):972-984. doi: 10.2174/1567205017666201130092427

M. Čuljak, et al., "The Association between TNF-alpha, IL-1 alpha and IL-10 with Alzheimer's Disease", Current Alzheimer Research, vol. 17, br. 11, str. 972-984, Siječanj 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:201249. [Citirano: 07.11.2024.]

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Podaci o radu
Naslov (engleski)The Association between TNF-alpha, IL-1 alpha and IL-10 with Alzheimer's Disease
AutorMarija Čuljak
AutorMatea Nikolac Perković
AutorSuzana Uzun
AutorDubravka Švob Štrac
AutorGordana Nedić Erjavec
AutorMirjana Babić Leko
AutorGoran Šimić
AutorLucija Tudor
AutorMarcela Konjevod
AutorOliver Kozumplik
AutorNinoslav Mimica
AutorNela Pivac
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(HRVATSKI INSTITUT ZA ISTRAŽIVANJE MOZGA)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PSIHIJATRIJU I PSIHOLOŠKU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Psihijatrija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Neuroznanost
Sažetak (engleski)
Background: Sporadic Alzheimer's Disease (AD) is assumed to be associated with different biological/genetic vulnerability, as well as with neuroinflammation, mediated by cytokines. The present study evaluated the role of cytokines in AD. ----- Objective: The aim was to determine the possible association of TNF-α (rs1800629), IL1-α (rs1800587) and IL-10 (rs1800896) polymorphisms with AD, and to assess serum TNF-α, IL-1α and IL-10 concentrations in patients with AD and in subjects with mild cognitive impairment (MCI). ----- Methods: The study included 645 Caucasian participants: 395 subjects with AD and 250 subjects with MCI. Genotyping was performed using real-time PCR in all 645 subjects, while serum concentrations of TNF-α, IL-1α and IL-10 and were determined using ELISA in 174 subjects. ----- Results: The frequency of the TNF-α rs1800629, IL1-α rs1800587 or IL-10 rs1800896 genotypes did not differ significantly between patients with AD and MCI. Serum concentration of IL-1α and IL-10 were significantly decreased, while the concentration of TNF-α was significantly higher in patients with AD than in MCI subjects. TNF-α, IL1-α or IL-10 concentrations were similar in subjects with AD or MCI subdivided into carriers of the corresponding TNF-α rs1800629, IL1-α rs1800587 or IL-10 rs1800896 genotypes. ----- Conclusion: Similar distribution of the IL1-α rs1800587, TNF-α rs1800629 or IL-10 rs1800896 genotypes in subjects with AD and MCI failed to confirm that these specific risk genotypes are associated with vulnerability to develop AD. Alteration in IL-1α, IL-10 and TNF-α concentrations in patients with AD partially confirmed the association with the neuroinflammatory response in AD.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaCurrent Alzheimer Research
Brojčani podacivol. 17, br. 11, str. 972-984
p-ISSN1567-2050
e-ISSN1875-5828
DOIhttps://doi.org/10.2174/1567205017666201130092427
URN:NBNurn:nbn:hr:105:201249
Datum objave publikacije2021-01-21
URL dokumentahttps://www.eurekaselect.com/188488/article
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Datum isteka embarga: 2021-12-01
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2021-05-20 08:15:46