prikaz prve stranice dokumenta Structural changes in brains of patients with disorders of consciousness treated with deep brain stimulation
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Structural changes in brains of patients with disorders of consciousness treated with deep brain stimulation
Scientific Reports, 11 (2021); 4401. https://doi.org/10.1038/s41598-021-83873-y
Raguž, Marina; Predrijevac, Nina; Dlaka, Domagoj; Orešković, Darko; Rotim, Ante; Romić, Dominik; Almahariq, Fadi; Marčinković, Petar; Deletis, Vedran; Kostović, Ivica; Chudy, Darko

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Raguž, M., Predrijevac, N., Dlaka, D., Orešković, D., Rotim, A., Romić, D. ... Chudy, D. (2021). Structural changes in brains of patients with disorders of consciousness treated with deep brain stimulation. Scientific Reports, 11.. doi: 10.1038/s41598-021-83873-y

Raguž, Marina, et al. "Structural changes in brains of patients with disorders of consciousness treated with deep brain stimulation." Scientific Reports, vol. 11, 2021. https://doi.org/10.1038/s41598-021-83873-y

Raguž, Marina, Nina Predrijevac, Domagoj Dlaka, Darko Orešković, Ante Rotim, Dominik Romić, Fadi Almahariq, et al. "Structural changes in brains of patients with disorders of consciousness treated with deep brain stimulation." Scientific Reports 11 (2021). https://doi.org/10.1038/s41598-021-83873-y

Raguž, M., et al. (2021) 'Structural changes in brains of patients with disorders of consciousness treated with deep brain stimulation', Scientific Reports, 11. doi: 10.1038/s41598-021-83873-y

Raguž M, Predrijevac N, Dlaka D, Orešković D, Rotim A, Romić D, i sur.. Structural changes in brains of patients with disorders of consciousness treated with deep brain stimulation. Scientific Reports [Internet]. 23.02.2021. [pristupljeno 18.10.2024.];11. doi: 10.1038/s41598-021-83873-y

M. Raguž, et al., "Structural changes in brains of patients with disorders of consciousness treated with deep brain stimulation", Scientific Reports, vol. 11, Veljača 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:252363. [Citirano: 18.10.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:252363
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Podaci o radu
Naslov (engleski)Structural changes in brains of patients with disorders of consciousness treated with deep brain stimulation
AutorMarina Raguž
AutorNina Predrijevac
AutorDomagoj Dlaka
AutorDarko Orešković
AutorAnte Rotim
AutorDominik Romić
AutorFadi Almahariq
AutorPetar Marčinković
AutorVedran Deletis
AutorIvica Kostović
AutorDarko Chudy
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(HRVATSKI INSTITUT ZA ISTRAŽIVANJE MOZGA)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA KIRURGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Kirurgija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Neuroznanost
Sažetak (engleski)
Disorders of consciousness (DOC) are one of the major consequences after anoxic or traumatic brain injury. So far, several studies have described the regaining of consciousness in DOC patients using deep brain stimulation (DBS). However, these studies often lack detailed data on the structural and functional cerebral changes after such treatment. The aim of this study was to conduct a volumetric analysis of specific cortical and subcortical structures to determine the impact of DBS after functional recovery of DOC patients. Five DOC patients underwent unilateral DBS electrode implantation into the centromedian parafascicular complex of the thalamic intralaminar nuclei. Consciousness recovery was confirmed using the Rappaport Disability Rating and the Coma/Near Coma scale. Brain MRI volumetric measurements were done prior to the procedure, then approximately a year after, and finally 7 years after the implementation of the electrode. The volumetric analysis included changes in regional cortical volumes and thickness, as well as in subcortical structures. Limbic cortices (parahippocampal and cingulate gyrus) and paralimbic cortices (insula) regions showed a significant volume increase and presented a trend of regional cortical thickness increase 1 and 7 years after DBS. The volumes of related subcortical structures, namely the caudate, the hippocampus as well as the amygdala, were significantly increased 1 and 7 years after DBS, while the putamen and nucleus accumbens presented with volume increase. Volume increase after DBS could be a result of direct DBS effects, or a result of functional recovery. Our findings are in accordance with the results of very few human studies connecting DBS and brain volume increase. Which mechanisms are behind the observed brain changes and whether structural changes are caused by consciousness recovery or DBS in patients with DOC is still a matter of debate.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaScientific Reports
Brojčani podacivol. 11, 4401
e-ISSN2045-2322
DOIhttps://doi.org/10.1038/s41598-021-83873-y
URN:NBNurn:nbn:hr:105:252363
Datum objave publikacije2021-02-23
URL dokumentahttp://www.nature.com/articles/s41598-021-83873-y
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2021-06-28 10:08:42