prikaz prve stranice dokumenta Addition of Rituximab in Reduced Intensity Conditioning Regimens for B-Cell Malignancies Does Not Influence Transplant Outcomes: EBMT Registry Analyses Following Allogeneic Stem Cell Transplantation for B-Cell Malignancies
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Addition of Rituximab in Reduced Intensity Conditioning Regimens for B-Cell Malignancies Does Not Influence Transplant Outcomes: EBMT Registry Analyses Following Allogeneic Stem Cell Transplantation for B-Cell Malignancies
Frontiers in Immunology, 11 (2021); 613954. https://doi.org/10.3389/fimmu.2020.613954
Tomaszewska, Agnieszka; Jagasia, Madan; Beohou, Eric; van der Werf, Steffie; Blaise, Didier; Kanfer, Edward; Milpied, Noel; Reményi, Péter; Ciceri, Fabio; Bourhis, Jean H.; Chevallier, Patrice; Solano, Carlos; Socié, Gerard; Bruno, Benedetto; Rambaldi, Alessandro; Castagna, Luca; Kröger, Nicolaus; Corradini, Paolo; Afanasyev, Boris; Ladetto, Marco; Niederwieser, Dietger; Scheid, Christof; Sengeloev, Henrik; Kroschinsky, Frank; Yakoub-Agha, Ibrahim; Schoemans, Helene; Koenecke, Christian; Penack, Olaf; Perić, Zinaida; Greinix, Hildegard; Duarte, Rafael F.; Basak, Grzegorz W. Više autora...

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Tomaszewska, A., Jagasia, M., Beohou, E., van der Werf, S., Blaise, D., Kanfer, E. ... Basak, G. W. (2021). Addition of Rituximab in Reduced Intensity Conditioning Regimens for B-Cell Malignancies Does Not Influence Transplant Outcomes: EBMT Registry Analyses Following Allogeneic Stem Cell Transplantation for B-Cell Malignancies. Frontiers in Immunology, 11.. doi: 10.3389/fimmu.2020.613954

Tomaszewska, Agnieszka, et al. "Addition of Rituximab in Reduced Intensity Conditioning Regimens for B-Cell Malignancies Does Not Influence Transplant Outcomes: EBMT Registry Analyses Following Allogeneic Stem Cell Transplantation for B-Cell Malignancies." Frontiers in Immunology, vol. 11, 2021. https://doi.org/10.3389/fimmu.2020.613954

Tomaszewska, Agnieszka, Madan Jagasia, Eric Beohou, Steffie van der Werf, Didier Blaise, Edward Kanfer, Noel Milpied, et al. "Addition of Rituximab in Reduced Intensity Conditioning Regimens for B-Cell Malignancies Does Not Influence Transplant Outcomes: EBMT Registry Analyses Following Allogeneic Stem Cell Transplantation for B-Cell Malignancies." Frontiers in Immunology 11 (2021). https://doi.org/10.3389/fimmu.2020.613954

Tomaszewska, A., et al. (2021) 'Addition of Rituximab in Reduced Intensity Conditioning Regimens for B-Cell Malignancies Does Not Influence Transplant Outcomes: EBMT Registry Analyses Following Allogeneic Stem Cell Transplantation for B-Cell Malignancies', Frontiers in Immunology, 11. doi: 10.3389/fimmu.2020.613954

Tomaszewska A, Jagasia M, Beohou E, van der Werf S, Blaise D, Kanfer E, i sur.. Addition of Rituximab in Reduced Intensity Conditioning Regimens for B-Cell Malignancies Does Not Influence Transplant Outcomes: EBMT Registry Analyses Following Allogeneic Stem Cell Transplantation for B-Cell Malignancies. Frontiers in Immunology [Internet]. 02.2021. [pristupljeno 19.04.2024.];11. doi: 10.3389/fimmu.2020.613954

A. Tomaszewska, et al., "Addition of Rituximab in Reduced Intensity Conditioning Regimens for B-Cell Malignancies Does Not Influence Transplant Outcomes: EBMT Registry Analyses Following Allogeneic Stem Cell Transplantation for B-Cell Malignancies", Frontiers in Immunology, vol. 11, Veljača 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:878916. [Citirano: 19.04.2024.]

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Naslov (engleski)Addition of Rituximab in Reduced Intensity Conditioning Regimens for B-Cell Malignancies Does Not Influence Transplant Outcomes: EBMT Registry Analyses Following Allogeneic Stem Cell Transplantation for B-Cell Malignancies
AutorAgnieszka Tomaszewska
AutorMadan Jagasia
AutorEric Beohou
AutorSteffie van der Werf
AutorDidier Blaise
AutorEdward Kanfer
AutorNoel Milpied
AutorPéter Reményi
AutorFabio Ciceri
AutorJean H. Bourhis
AutorPatrice Chevallier
AutorCarlos Solano
AutorGerard Socié
AutorBenedetto Bruno
AutorAlessandro Rambaldi
AutorLuca Castagna
AutorNicolaus Kröger
AutorPaolo Corradini
AutorBoris Afanasyev
AutorMarco Ladetto
AutorDietger Niederwieser
AutorChristof Scheid
AutorHenrik Sengeloev
AutorFrank Kroschinsky
AutorIbrahim Yakoub-Agha
AutorHelene Schoemans
AutorChristian Koenecke
AutorOlaf Penack
AutorZinaida Perić
AutorHildegard Greinix
AutorRafael F. Duarte
AutorGrzegorz W. Basak
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Rituximab (R) is increasingly incorporated in reduced intensity conditioning (RIC) regimens for allogeneic hematopoietic cell transplantation (alloHCT) in patients with B-cell malignancies, not only to improve disease control, but also to prevent graft-versus-host disease (GVHD). There are no randomized prospective data to validate this practice, although single center data and the CIBMTR analysis have shown promising results. We aimed at validation of these findings in a large registry study. We conducted a retrospective analysis using the EBMT registry of 3,803 adult patients with B-cell malignancies undergoing alloHCT (2001–2013) with either rituximab (R-RIC-9%) or non-rituximab (RIC-91%) reduced intensity regimens respectively. Median age and median follow up were 55 years (range 19.1–77.3) and 43.2 months (range 0.3–179.8), respectively. There was no difference in transplant outcomes (R-RIC vs RIC), including 1-year overall survival (69.9% vs 70.7%), 1-year disease-free survival (64.4% vs 62.2%), 1-year non-relapse mortality (21% vs 22%), and day-100 incidence of acute GVHD 2-4° (12% vs 12%). In summary, we found that addition of rituximab in RIC regimens for B-cell malignancies had no significant impact on major transplant outcome variables. Of note, data on chronic GVHD was not available, limiting the conclusions that can be drawn from the present study.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaFrontiers in Immunology
Brojčani podacivol. 11, 613954
e-ISSN1664-3224
DOIhttps://doi.org/10.3389/fimmu.2020.613954
URN:NBNurn:nbn:hr:105:878916
Datum objave publikacije2021-02
URL dokumentahttps://www.frontiersin.org/articles/10.3389/fimmu.2020.613954/full
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2021-06-29 08:27:34