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How far along are we in revealing the connection between metformin and colorectal cancer?
World Journal of Gastroenterology, 27 (2021), 14; 1362-1368. https://doi.org/10.3748/wjg.v27.i14.1362
Cigrovski Berković, Maja; Mikulić, Danko; Bilić-Ćurčić, Ines; Mrzljak, Anna

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Cigrovski Berković, M., Mikulić, D., Bilić Ćurčić, I. i Mrzljak, A. (2021). How far along are we in revealing the connection between metformin and colorectal cancer?. World Journal of Gastroenterology, 27. (14), 1362-1368. doi: 10.3748/wjg.v27.i14.1362

Cigrovski Berković, Maja, et al. "How far along are we in revealing the connection between metformin and colorectal cancer?." World Journal of Gastroenterology, vol. 27, br. 14, 2021, str. 1362-1368. https://doi.org/10.3748/wjg.v27.i14.1362

Cigrovski Berković, Maja, Danko Mikulić, Ines Bilić Ćurčić i Anna Mrzljak. "How far along are we in revealing the connection between metformin and colorectal cancer?." World Journal of Gastroenterology 27, br. 14 (2021): 1362-1368. https://doi.org/10.3748/wjg.v27.i14.1362

Cigrovski Berković, M., et al. (2021) 'How far along are we in revealing the connection between metformin and colorectal cancer?', World Journal of Gastroenterology, 27(14), str. 1362-1368. doi: 10.3748/wjg.v27.i14.1362

Cigrovski Berković M, Mikulić D, Bilić Ćurčić I, Mrzljak A. How far along are we in revealing the connection between metformin and colorectal cancer?. World Journal of Gastroenterology [Internet]. 14.04.2021. [pristupljeno 20.12.2024.];27(14):1362-1368. doi: 10.3748/wjg.v27.i14.1362

M. Cigrovski Berković, D. Mikulić, I. Bilić Ćurčić i A. Mrzljak, "How far along are we in revealing the connection between metformin and colorectal cancer?", World Journal of Gastroenterology, vol. 27, br. 14, str. 1362-1368, Travanj 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:547932. [Citirano: 20.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:547932
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Podaci o radu
Naslov (engleski)How far along are we in revealing the connection between metformin and colorectal cancer?
AutorMaja Cigrovski Berković
AutorDanko Mikulić
AutorInes Bilić-Ćurčić
AutorAnna Mrzljak
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Colorectal cancer (CRC) is among the most prevalent cancers worldwide, and its prevention and reduction of incidence is imperative. The presence of diabetes has been associated with a 30% increased risk of CRC, likely through the mechanism of hyperinsulinemia, which promotes tumorigenesis via the insulin receptor in the epithelium or by insulin-like growth factor pathways, inflammation, or adipokines, inducing cancer cell proliferation and cancer spread. Metformin, the first-line agent in treating type 2 diabetes, has a chemopreventive role in CRC development. Additionally, preclinical studies suggest synergistic effects of metformin with oxaliplatin in inhibiting in vitro models of colon cancer. Although preclinical studies on the post diagnostic use of metformin were promising and suggested its synergistic effects with chemotherapy, the data on the possible effects of metformin after surgery and other CRC treatment in the clinical setting are less conclusive, and randomized controlled trials are still lacking.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaWorld Journal of Gastroenterology
Brojčani podacivol. 27, br. 14, str. 1362-1368
p-ISSN1007-9327
e-ISSN2219-2840
DOIhttps://doi.org/10.3748/wjg.v27.i14.1362
URN:NBNurn:nbn:hr:105:547932
Datum objave publikacije2021-04-14
URL dokumentahttps://www.wjgnet.com/1007-9327/full/v27/i14/1362.htm
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno 4.0 međunarodna (CC BY-NC 4.0)
Datum i vrijeme pohrane2021-10-15 07:51:05