prikaz prve stranice dokumenta Post-COVID-19 exacerbation of fibrodysplasia ossificans progressiva with multiple flare-ups and extensive heterotopic ossification in a 45-year-old female patient
  Preuzmi
PDF 1.75 MB
Znanstveni rad - Pregledni rad
Post-COVID-19 exacerbation of fibrodysplasia ossificans progressiva with multiple flare-ups and extensive heterotopic ossification in a 45-year-old female patient
Rheumatology International, 41 (2021), 8; 1495-1501. https://doi.org/10.1007/s00296-021-04911-6
Grgurević, Lovorka; Novak, Ruđer; Hrkač, Stela; Salai, Grgur; Grazio, Simeon

Povezani objekti
COVID-19 | Virtualna zbirka
Citirajte ovaj rad

Grgurević, L., Novak, R., Hrkač, S., Salai, G. i Grazio, S. (2021). Post-COVID-19 exacerbation of fibrodysplasia ossificans progressiva with multiple flare-ups and extensive heterotopic ossification in a 45-year-old female patient. Rheumatology International, 41. (8), 1495-1501. doi: 10.1007/s00296-021-04911-6

Grgurević, Lovorka, et al. "Post-COVID-19 exacerbation of fibrodysplasia ossificans progressiva with multiple flare-ups and extensive heterotopic ossification in a 45-year-old female patient." Rheumatology International, vol. 41, br. 8, 2021, str. 1495-1501. https://doi.org/10.1007/s00296-021-04911-6

Grgurević, Lovorka, Ruđer Novak, Stela Hrkač, Grgur Salai i Simeon Grazio. "Post-COVID-19 exacerbation of fibrodysplasia ossificans progressiva with multiple flare-ups and extensive heterotopic ossification in a 45-year-old female patient." Rheumatology International 41, br. 8 (2021): 1495-1501. https://doi.org/10.1007/s00296-021-04911-6

Grgurević, L., et al. (2021) 'Post-COVID-19 exacerbation of fibrodysplasia ossificans progressiva with multiple flare-ups and extensive heterotopic ossification in a 45-year-old female patient', Rheumatology International, 41(8), str. 1495-1501. doi: 10.1007/s00296-021-04911-6

Grgurević L, Novak R, Hrkač S, Salai G, Grazio S. Post-COVID-19 exacerbation of fibrodysplasia ossificans progressiva with multiple flare-ups and extensive heterotopic ossification in a 45-year-old female patient. Rheumatology International [Internet]. 08.2021. [pristupljeno 11.04.2024.];41(8):1495-1501. doi: 10.1007/s00296-021-04911-6

L. Grgurević, R. Novak, S. Hrkač, G. Salai i S. Grazio, "Post-COVID-19 exacerbation of fibrodysplasia ossificans progressiva with multiple flare-ups and extensive heterotopic ossification in a 45-year-old female patient", Rheumatology International, vol. 41, br. 8, str. 1495-1501, Kolovoz 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:578316. [Citirano: 11.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:578316
Prijavite se u repozitorij kako biste mogli spremiti objekt u svoju listu.
Podaci o radu
Naslov (engleski)Post-COVID-19 exacerbation of fibrodysplasia ossificans progressiva with multiple flare-ups and extensive heterotopic ossification in a 45-year-old female patient
AutorLovorka Grgurević
AutorRuđer Novak
AutorStela Hrkač
AutorGrgur Salai
AutorSimeon Grazio
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA ANATOMIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Anatomija
Sažetak (engleski)
Abstract Fibrodyplasia ossificans progressiva (FOP) is a rare hereditary disease, which has a variable course characterized by occasional flare-ups of heterotopic ossification (HO) in soft tissues that are followed by swelling, stiffness, pain and warmth. Here, we report for the first time a case of a 45-year-old female patient with known FOP recovering from COVID-19 with disease progression potentially linked with the viral illness. In December 2020 the patient contracted a mild form of COVID-19 infection without need for hospital admission. Since January 2021, the patient felt unwell, with occasional abdominal pain which progressively intensified. In March 2021 she presented with new onset of HO, complaining of pain, swelling and thickening sensation in the lower abdomen and left part of the neck. Computerized tomography (CT) and cytokine analysis were performed. CT scan revealed new heterotopic bone formation in multiple soft tissue areas of the neck indicating clear radiological progression. Radiotherapy, which has proven to be an efficient tool to control HO in this patient, was not able to halt HO formation after COVID-19 infection. Cytokine analysis of a plasma sample obtained during a flare-up after COVID-19 infection showed a significantly elevated pro-inflammatory cytokines compared to a flare-up panel prior to infection. Of the 23 analyzed levels of cytokines, a staggering number of 21 were above normal levels. This case is the first confirmation of uncontrolled post-COVID-19 effects in a FOP patient, which manifested with flare-ups followed by progressive HO, possibly caused by a thus far, never described form of post-COVID syndrome.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaRheumatology International
Brojčani podacivol. 41, br. 8, str. 1495-1501
p-ISSN0172-8172
e-ISSN1437-160X
DOIhttps://doi.org/10.1007/s00296-021-04911-6
URN:NBNurn:nbn:hr:105:578316
Datum objave publikacije2021-08
URL dokumentahttps://link.springer.com/10.1007/s00296-021-04911-6
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2021-11-15 11:58:46