prikaz prve stranice dokumenta Impact of age on the cumulative risk of transformation in patients with chronic myelomonocytic leukaemia
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Impact of age on the cumulative risk of transformation in patients with chronic myelomonocytic leukaemia
European Journal of Haematology, 107 (2021), 2; 265-274. https://doi.org/10.1111/ejh.13647
Machherndl‐Spandl, Sigrid; Jäger, Eva; Barna, Agnes; Gurbisz, Michael; Marschon, Renate; Graf, Temeida; Graf, Elmir; Geissler, Christoph; Hoermann, Gregor; Nösslinger, Thomas; Pfeilstöcker, Michael; Bettelheim, Peter; Zach, Otto; Weltermann, Ansgar; Heibl, Sonja; Thaler, Josef; Zebisch, Armin; Sill, Heinz; Stauder, Reinhard; Webersinke, Gerald; Kušec, Rajko; Ulsperger, Ernst; Schneeweiss, Bruno; Öhler, Leopold; Germing, Ulrich; Valent, Peter; Tüchler, Heinz; Geissler, Klaus Više autora...

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Machherndl‐Spandl, S., Jäger, E., Barna, A., Gurbisz, M., Marschon, R., Graf, T. ... Geissler, K. (2021). Impact of age on the cumulative risk of transformation in patients with chronic myelomonocytic leukaemia. European Journal of Haematology, 107. (2), 265-274. doi: 10.1111/ejh.13647

Machherndl‐Spandl, Sigrid, et al. "Impact of age on the cumulative risk of transformation in patients with chronic myelomonocytic leukaemia." European Journal of Haematology, vol. 107, br. 2, 2021, str. 265-274. https://doi.org/10.1111/ejh.13647

Machherndl‐Spandl, Sigrid, Eva Jäger, Agnes Barna, Michael Gurbisz, Renate Marschon, Temeida Graf, Elmir Graf, et al. "Impact of age on the cumulative risk of transformation in patients with chronic myelomonocytic leukaemia." European Journal of Haematology 107, br. 2 (2021): 265-274. https://doi.org/10.1111/ejh.13647

Machherndl‐Spandl, S., et al. (2021) 'Impact of age on the cumulative risk of transformation in patients with chronic myelomonocytic leukaemia', European Journal of Haematology, 107(2), str. 265-274. doi: 10.1111/ejh.13647

Machherndl‐Spandl S, Jäger E, Barna A, Gurbisz M, Marschon R, Graf T, i sur.. Impact of age on the cumulative risk of transformation in patients with chronic myelomonocytic leukaemia. European Journal of Haematology [Internet]. 08.2021. [pristupljeno 15.02.2025.];107(2):265-274. doi: 10.1111/ejh.13647

S. Machherndl‐Spandl, et al., "Impact of age on the cumulative risk of transformation in patients with chronic myelomonocytic leukaemia", European Journal of Haematology, vol. 107, br. 2, str. 265-274, Kolovoz 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:108756. [Citirano: 15.02.2025.]

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Naslov (engleski)Impact of age on the cumulative risk of transformation in patients with chronic myelomonocytic leukaemia
AutorSigrid Machherndl‐Spandl
AutorEva Jäger
AutorAgnes Barna
AutorMichael Gurbisz
AutorRenate Marschon
AutorTemeida Graf
AutorElmir Graf
AutorChristoph Geissler
AutorGregor Hoermann
AutorThomas Nösslinger
AutorMichael Pfeilstöcker
AutorPeter Bettelheim
AutorOtto Zach
AutorAnsgar Weltermann
AutorSonja Heibl
AutorJosef Thaler
AutorArmin Zebisch
AutorHeinz Sill
AutorReinhard Stauder
AutorGerald Webersinke
AutorRajko Kušec
AutorErnst Ulsperger
AutorBruno Schneeweiss
AutorLeopold Öhler
AutorUlrich Germing
AutorPeter Valent
AutorHeinz Tüchler
AutorKlaus Geissler
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
In older patients with chronic myelomonocytic leukaemia (CMML) and limited life expectancy due to age and or comorbidities, it is particularly important to consider the risk of transformation for individualised treatment decisions. There is limited information on potential differences between younger and older CMML patients regarding the cumulative risk of transformation as well as haematological, molecular and biologic characteristics. We analysed data from the Austrian Biodatabase for CMML (ABCMML) to compare these parameters in 518 CMML patients. Categorisation of patients into 3 age-related groups: <60 years, 60-79 years and ≥80 years, showed a significantly lower risk of transformation at higher age by competing risk analysis, with a 4-year risk of 39%, 23% and 13%, respectively (P < .0001). The lower probability of transformation was associated with a lower percentage of blast cells in the peripheral blood (PB) of older patients. Furthermore, we provide a simple score based on age, PB blasts and platelet counts that allowed us to define subgroups of CMML patients with a different cumulative transformation risk, including a low-risk group with a transformation risk of only 5%. Our findings may facilitate reasonable treatment decisions in elderly patients with CMML.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaEuropean Journal of Haematology
Brojčani podacivol. 107, br. 2, str. 265-274
p-ISSN0902-4441
e-ISSN1600-0609
DOIhttps://doi.org/10.1111/ejh.13647
URN:NBNurn:nbn:hr:105:108756
Datum objave publikacije2021-08
URL dokumentahttps://onlinelibrary.wiley.com/doi/10.1111/ejh.13647
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-01-10 10:33:05