prikaz prve stranice dokumenta Bone morphogenetic protein 1.3 inhibition decreases scar formation and supports cardiomyocyte survival after myocardial infarction
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Bone morphogenetic protein 1.3 inhibition decreases scar formation and supports cardiomyocyte survival after myocardial infarction
Nature Communications, 13 (2022), 1; 81. https://doi.org/10.1038/s41467-021-27622-9
Vukičević, Slobodan; Colliva, Andrea; Kufner, Vera; Martinelli, Valentina; Moimas, Silvia; Vodret, Simone; Rumenović, Viktorija; Milošević, Milan; Brkljačić, Boris; Delić-Brkljačić, Diana; Correa, Ricardo; Giacca, Mauro; Maglione, Manuel; Bordukalo-Nikšić, Tatjana; Dumić-Čule, Ivo; Zacchigna, Serena Više autora...

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Vukičević, S., Colliva, A., Kufner, V., Martinelli, V., Moimas, S., Vodret, S. ... Zacchigna, S. (2022). Bone morphogenetic protein 1.3 inhibition decreases scar formation and supports cardiomyocyte survival after myocardial infarction. Nature Communications, 13. (1). doi: 10.1038/s41467-021-27622-9

Vukičević, Slobodan, et al. "Bone morphogenetic protein 1.3 inhibition decreases scar formation and supports cardiomyocyte survival after myocardial infarction." Nature Communications, vol. 13, br. 1, 2022. https://doi.org/10.1038/s41467-021-27622-9

Vukičević, Slobodan, Andrea Colliva, Vera Kufner, Valentina Martinelli, Silvia Moimas, Simone Vodret, Viktorija Rumenović, et al. "Bone morphogenetic protein 1.3 inhibition decreases scar formation and supports cardiomyocyte survival after myocardial infarction." Nature Communications 13, br. 1 (2022). https://doi.org/10.1038/s41467-021-27622-9

Vukičević, S., et al. (2022) 'Bone morphogenetic protein 1.3 inhibition decreases scar formation and supports cardiomyocyte survival after myocardial infarction', Nature Communications, 13(1). doi: 10.1038/s41467-021-27622-9

Vukičević S, Colliva A, Kufner V, Martinelli V, Moimas S, Vodret S, i sur.. Bone morphogenetic protein 1.3 inhibition decreases scar formation and supports cardiomyocyte survival after myocardial infarction. Nature Communications [Internet]. 10.01.2022. [pristupljeno 01.12.2024.];13(1). doi: 10.1038/s41467-021-27622-9

S. Vukičević, et al., "Bone morphogenetic protein 1.3 inhibition decreases scar formation and supports cardiomyocyte survival after myocardial infarction", Nature Communications, vol. 13, br. 1, Siječanj 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:938875. [Citirano: 01.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:938875
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Naslov (engleski)Bone morphogenetic protein 1.3 inhibition decreases scar formation and supports cardiomyocyte survival after myocardial infarction
AutorSlobodan Vukičević
AutorAndrea Colliva
AutorVera Kufner
AutorValentina Martinelli
AutorSilvia Moimas
AutorSimone Vodret
AutorViktorija Rumenović
AutorMilan Milošević
AutorBoris Brkljačić
AutorDiana Delić-Brkljačić
AutorRicardo Correa
AutorMauro Giacca
AutorManuel Maglione
AutorTatjana Bordukalo-Nikšić
AutorIvo Dumić-Čule
AutorSerena Zacchigna
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA ANATOMIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA RADIOLOGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA ZDRAVSTVENU EKOLOGIJU, MEDICINU RADA I SPORTA)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Radiologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Javno zdravstvo i zdravstvena zaštita
Medicina rada i športa
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Anatomija
Sažetak (engleski)
Abstract Despite the high prevalence of ischemic heart diseases worldwide, no antibody-based treatment currently exists. Starting from the evidence that a specific isoform of the Bone Morphogenetic Protein 1 (BMP1.3) is particularly elevated in both patients and animal models of myocardial infarction, here we assess whether its inhibition by a specific monoclonal antibody reduces cardiac fibrosis. We find that this treatment reduces collagen deposition and cross-linking, paralleled by enhanced cardiomyocyte survival, both in vivo and in primary cultures of cardiac cells. Mechanistically, we show that the anti-BMP1.3 monoclonal antibody inhibits Transforming Growth Factor β pathway, thus reducing myofibroblast activation and inducing cardioprotection through BMP5. Collectively, these data support the therapeutic use of anti-BMP1.3 antibodies to prevent cardiomyocyte apoptosis, reduce collagen deposition and preserve cardiac function after ischemia.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaNature Communications
Brojčani podacivol. 13, br. 1, 81
e-ISSN2041-1723
DOIhttps://doi.org/10.1038/s41467-021-27622-9
URN:NBNurn:nbn:hr:105:938875
Datum objave publikacije2022-01-10
URL dokumentahttps://www.nature.com/articles/s41467-021-27622-9
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-01-12 13:37:43