Immunohistochemical Expression of Wnt-4 Protein in Clear Cell Renal Carcinoma

Znanstveni rad - Izvorni znanstveni rad

• Autor: Oliver Pavlović
• Autor: Tvrtko Hudolin
• Autor: Ivan Miškulin
• Autor: Stela Bulimbašić
• Autor: Marijana Ćorić
• Autor: Josip Perković
• Autor: Toni Zekulić
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet; (KATEDRA ZA PATOLOGIJU)
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet; (KATEDRA ZA UROLOGIJU)
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Kliničke medicinske znanosti; Patologija
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Kliničke medicinske znanosti; Urologija

Sažetak (engleski)

Wingless binding integration site proteins (Wnt) have an important role in normal kidney development and in various kidney diseases. They are required for complete epithelial differentiation and normal nephron formation. Changes in these proteins could also have important role in carcinogenesis. This study included 185 patients with clear cell renal carcinoma (ccRCC) in whom immunohistochemical expression of Wnt-4 protein in healthy and tumorous tissue after surgery was investigated. There was higher expression of Wnt-4 in healthy than in tumor tissue. No difference between Fuhrman’s grade and Wnt-4 expression was found. A poor negative correlation between tumor size and Wnt-4 expression was found. Patients with suspected metastatic diseases had higher Wnt-4 expression. There was no difference in survival rates between Wnt-4 negative and positive groups. In our study we have shown that high Wnt-4 expression in healthy tissue decreases in low-grade tumors but then increases in high-grade tumors, suggesting that tumor progression requires Wnt-4 activation or reactivation.

• Ključne riječi (engleski): Wnt signaling pathway; Wnt-4 protein; clear cell renal carcinoma; immunohistochemistry
• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Izvorni znanstveni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: Journal of Clinical Medicine
• Brojčani podaci: vol. 10, br. 24, 5795
• e-ISSN: 2077-0383
• DOI: https://doi.org/10.3390/jcm10245795
• URN:NBN: urn:nbn:hr:105:994891
• Datum objave publikacije: 2021-12-11
• URL dokumenta: https://www.mdpi.com/2077-0383/10/24/5795
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2022-02-01 09:44:02