prikaz prve stranice dokumenta Impact of the type of anthracycline and of stem cell transplantation in younger patients with acute myeloid leukaemia: Long‐term follow up of a phase study
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Impact of the type of anthracycline and of stem cell transplantation in younger patients with acute myeloid leukaemia: Long‐term follow up of a phase study
American Journal of Hematology, 95 (2020), 7; 749-758. https://doi.org/10.1002/ajh.25795
Baron, Frédéric; Efficace, Fabio; Cannella, Laura; Muus, Petra; Trisolini, Silvia; Halkes, Constantijn J. M.; Fazi, Paola; Vignetti, Marco; Marie, Jean‐Pierre; Chiusolo, Patrizia; Velden, Walter; La Sala, Edoardo; Vitolo, Umberto; Thomas, Xavier; Lefrère, Francois; Di Raimondo, Francesco; Bourhis, Jean‐Henri; Specchia, Giorgina; Guimarães, José E.; Allione, Bernardino; Vrhovac, Radovan; Ferrara, Felicetto; Stevens‐Kroef, Marian; Meert, Liv; Witte, Theo; Willemze, Roelof; Amadori, Sergio; Suciu, Stefan Više autora...

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Baron, F., Efficace, F., Cannella, L., Muus, P., Trisolini, S., Halkes, C. J. M. ... Suciu, S. (2020). Impact of the type of anthracycline and of stem cell transplantation in younger patients with acute myeloid leukaemia: Long‐term follow up of a phase study. American Journal of Hematology, 95. (7), 749-758. doi: 10.1002/ajh.25795

Baron, Frédéric, et al. "Impact of the type of anthracycline and of stem cell transplantation in younger patients with acute myeloid leukaemia: Long‐term follow up of a phase study." American Journal of Hematology, vol. 95, br. 7, 2020, str. 749-758. https://doi.org/10.1002/ajh.25795

Baron, Frédéric, Fabio Efficace, Laura Cannella, Petra Muus, Silvia Trisolini, Constantijn J. M. Halkes, Paola Fazi, et al. "Impact of the type of anthracycline and of stem cell transplantation in younger patients with acute myeloid leukaemia: Long‐term follow up of a phase study." American Journal of Hematology 95, br. 7 (2020): 749-758. https://doi.org/10.1002/ajh.25795

Baron, F., et al. (2020) 'Impact of the type of anthracycline and of stem cell transplantation in younger patients with acute myeloid leukaemia: Long‐term follow up of a phase study', American Journal of Hematology, 95(7), str. 749-758. doi: 10.1002/ajh.25795

Baron F, Efficace F, Cannella L, Muus P, Trisolini S, Halkes CJM, i sur.. Impact of the type of anthracycline and of stem cell transplantation in younger patients with acute myeloid leukaemia: Long‐term follow up of a phase study. American Journal of Hematology [Internet]. 07.2020. [pristupljeno 08.11.2024.];95(7):749-758. doi: 10.1002/ajh.25795

F. Baron, et al., "Impact of the type of anthracycline and of stem cell transplantation in younger patients with acute myeloid leukaemia: Long‐term follow up of a phase study", American Journal of Hematology, vol. 95, br. 7, str. 749-758, Srpanj 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:157213. [Citirano: 08.11.2024.]

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Naslov (engleski)Impact of the type of anthracycline and of stem cell transplantation in younger patients with acute myeloid leukaemia: Long‐term follow up of a phase study
AutorFrédéric Baron
AutorFabio Efficace
AutorLaura Cannella
AutorPetra Muus
AutorSilvia Trisolini
AutorConstantijn J. M. Halkes
AutorPaola Fazi
AutorMarco Vignetti
AutorJean‐Pierre Marie
AutorPatrizia Chiusolo
AutorWalter Velden
AutorEdoardo La Sala
AutorUmberto Vitolo
AutorXavier Thomas
AutorFrancois Lefrère
AutorFrancesco Di Raimondo
AutorJean‐Henri Bourhis
AutorGiorgina Specchia
AutorJosé E. Guimarães
AutorBernardino Allione
AutorRadovan Vrhovac
AutorFelicetto Ferrara
AutorMarian Stevens‐Kroef
AutorLiv Meert
AutorTheo Witte
AutorRoelof Willemze
AutorSergio Amadori
AutorStefan Suciu
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
We provide a long-term evaluation of patients enrolled in the EORTC/GIMEMA AML-10 trial which included a total of 2157 patients, 15-60 years old, randomized to receive either daunorubicin (DNR, 50 mg/m2 ), mitoxantrone (MXR, 12 mg/m2 ), or idarubicin (IDA, 10 mg/m2 ) in addition to standard-dose cytarabine and etoposide for induction chemotherapy and intermediate dose cytarabine for consolidation. Younger patients who reached complete remission with complete (CR) or incomplete (CRi) recovery were then scheduled to receive an allogeneic hematopoietic stem cell transplantation (HSCT). That was if they had a HLA-identical sibling donor; in all other cases, an autologous HSCT had to be administered. At an 11-year median follow-up, the 5-year, 10-year and 15-year overall survival (OS) rates were 33.2%, 30.1% and 28.0%, respectively. No significant difference between the three randomized groups regarding OS was observed (P = .38). In young patients, 15-45 years old, no treatment difference (P = .89) regarding OS was observed, while in patients 46-60 years old, MXR and IDA groups had a trend for a longer OS as compared to the DNR group (P = .029). Among younger patients without a favorable MRC cytogenetic risk subgroup who achieved a CR/CRi after induction chemotherapy, those with a HLA-identical sibling donor had higher 10-year and 15-year OS rates than those without. In older patients who reached CR/CRi, the long-term outcomes of those with or without a donor was similar. In conclusion, long-term outcomes of the study confirmed similar OS in the three randomized groups in the whole cohort of patients.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaAmerican Journal of Hematology
Brojčani podacivol. 95, br. 7, str. 749-758
p-ISSN0361-8609
e-ISSN1096-8652
DOIhttps://doi.org/10.1002/ajh.25795
URN:NBNurn:nbn:hr:105:157213
Datum objave publikacije2020-07
URL dokumentahttps://onlinelibrary.wiley.com/doi/10.1002/ajh.25795
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-02-04 08:45:01