prikaz prve stranice dokumenta Autologous blood coagulum containing rhBMP6 induces new bone formation to promote anterior lumbar interbody fusion (ALIF) and posterolateral lumbar fusion (PLF) of spine in sheep
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Autologous blood coagulum containing rhBMP6 induces new bone formation to promote anterior lumbar interbody fusion (ALIF) and posterolateral lumbar fusion (PLF) of spine in sheep
Bone, 138 (2020); 115448. https://doi.org/10.1016/j.bone.2020.115448
Grgurević, Lovorka; Erjavec, Igor; Gupta, Munish; Pećin, Marko; Bordukalo-Nikšić, Tatjana; Štoković, Nikola; Vnuk, Dražen; Farkaš, Vladimir; Capak, Hrvoje; Milošević, Milan; Bubić Špoljar, Jadranka; Perić, Mihaela; Vučković, Mirta; Matičić, Dražen; Windhager, Reinhard; Oppermann, Hermann; Sampath, T. Kuber; Vukičević, Slobodan Više autora...

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Grgurević, L., Erjavec, I., Gupta, M., Pećin, M., Bordukalo Nikšić, T., Štoković, N. ... Vukičević, S. (2020). Autologous blood coagulum containing rhBMP6 induces new bone formation to promote anterior lumbar interbody fusion (ALIF) and posterolateral lumbar fusion (PLF) of spine in sheep. Bone, 138.. doi: 10.1016/j.bone.2020.115448

Grgurević, Lovorka, et al. "Autologous blood coagulum containing rhBMP6 induces new bone formation to promote anterior lumbar interbody fusion (ALIF) and posterolateral lumbar fusion (PLF) of spine in sheep." Bone, vol. 138, 2020. https://doi.org/10.1016/j.bone.2020.115448

Grgurević, Lovorka, Igor Erjavec, Munish Gupta, Marko Pećin, Tatjana Bordukalo Nikšić, Nikola Štoković, Dražen Vnuk, et al. "Autologous blood coagulum containing rhBMP6 induces new bone formation to promote anterior lumbar interbody fusion (ALIF) and posterolateral lumbar fusion (PLF) of spine in sheep." Bone 138 (2020). https://doi.org/10.1016/j.bone.2020.115448

Grgurević, L., et al. (2020) 'Autologous blood coagulum containing rhBMP6 induces new bone formation to promote anterior lumbar interbody fusion (ALIF) and posterolateral lumbar fusion (PLF) of spine in sheep', Bone, 138. doi: 10.1016/j.bone.2020.115448

Grgurević L, Erjavec I, Gupta M, Pećin M, Bordukalo Nikšić T, Štoković N, i sur.. Autologous blood coagulum containing rhBMP6 induces new bone formation to promote anterior lumbar interbody fusion (ALIF) and posterolateral lumbar fusion (PLF) of spine in sheep. Bone [Internet]. 09.2020. [pristupljeno 11.04.2024.];138. doi: 10.1016/j.bone.2020.115448

L. Grgurević, et al., "Autologous blood coagulum containing rhBMP6 induces new bone formation to promote anterior lumbar interbody fusion (ALIF) and posterolateral lumbar fusion (PLF) of spine in sheep", Bone, vol. 138, Rujan 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:660078. [Citirano: 11.04.2024.]

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Naslov (engleski)Autologous blood coagulum containing rhBMP6 induces new bone formation to promote anterior lumbar interbody fusion (ALIF) and posterolateral lumbar fusion (PLF) of spine in sheep
AutorLovorka Grgurević
AutorIgor Erjavec
AutorMunish Gupta
AutorMarko Pećin
AutorTatjana Bordukalo-Nikšić
AutorNikola Štoković
AutorDražen Vnuk
AutorVladimir Farkaš
AutorHrvoje Capak
AutorMilan Milošević
AutorJadranka Bubić Špoljar
AutorMihaela Perić
MBZ: 222361
AutorMirta Vučković
AutorDražen Matičić
AutorReinhard Windhager
AutorHermann Oppermann
AutorT. Kuber Sampath
AutorSlobodan Vukičević
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA ANATOMIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Anatomija
Sažetak (engleski)
In the present study, we evaluated an autologous bone graft substitute (ABGS) composed of recombinant human BMP6 (rhBMP6) dispersed within autologous blood coagulum (ABC) used as a physiological carrier for new bone formation in spine fusion sheep models. The application of ABGS included cervical cage for use in the anterior lumbar interbody fusion (ALIF), while for the posterolateral lumbar fusion (PLF) sheep model allograft devitalized bone particles (ALLO) were applied with and without use of instrumentation. In the ALIF model, ABGS (rhBMP6/ABC/cage) implants fused significantly when placed in between the L4-L5 vertebrae as compared to control (ABC/cage) which appears to have a fibrocartilaginous gap, as examined by histology and micro CT analysis at 16 weeks following surgery. In the PLF model, ABGS implants with or without ALLO showed a complete fusion when placed ectopically in the gutter bilaterally between two decorticated L4-L5 transverse processes at a success rate of 88% without instrumentation and at 80% with instrumentation; however the bone volume was 50% lower in the instrumentation group than without, as examined by histology, radiographs, micro CT analyses and biomechanical testing at 27 weeks following surgery. The newly formed bone was uniform within ABGS implants resulting in a biomechanically competent and histologically qualified fusion with an optimum dose in the range of 100 μg rhBMP6 per mL ABC, while in the implants that contained ALLO, the mineralized bone particles were substituted by the newly formed remodeling bone via creeping substitution. These findings demonstrate for the first time that ABGS (rhBMP6/ABC) without and with ALLO particles induced a robust bone formation with a successful fusion in sheep models of ALIF and PLF, and that autologous blood coagulum (ABC) can serve as a preferred physiological native carrier to induce new bone at low doses of rhBMP6 and to achieve a successful spinal fusion.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBone
Brojčani podacivol. 138, 115448
p-ISSN8756-3282
e-ISSN1873-2763
DOIhttps://doi.org/10.1016/j.bone.2020.115448
URN:NBNurn:nbn:hr:105:660078
Datum objave publikacije2020-09
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S8756328220302283
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-02-04 09:04:10