prikaz prve stranice dokumenta Leydig Cells in Patients with Non-Obstructive Azoospermia: Do They Really Proliferate?
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Leydig Cells in Patients with Non-Obstructive Azoospermia: Do They Really Proliferate?
Life, 11 (2021), 11; 1266. https://doi.org/10.3390/life11111266
Hauptman, Dinko; Himelreich Perić, Marta; Marić, Tihana; Katušić Bojanac, Ana; Sinčić, Nino; Zimak, Zoran; Kaštelan, Željko; Ježek, Davor

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Hauptman, D., Himelreich Perić, M., Marić, T., Katušić Bojanac, A., Sinčić, N., Zimak, Z. ... Ježek, D. (2021). Leydig Cells in Patients with Non-Obstructive Azoospermia: Do They Really Proliferate?. Life, 11. (11). doi: 10.3390/life11111266

Hauptman, Dinko, et al. "Leydig Cells in Patients with Non-Obstructive Azoospermia: Do They Really Proliferate?." Life, vol. 11, br. 11, 2021. https://doi.org/10.3390/life11111266

Hauptman, Dinko, Marta Himelreich Perić, Tihana Marić, Ana Katušić Bojanac, Nino Sinčić, Zoran Zimak, Željko Kaštelan i Davor Ježek. "Leydig Cells in Patients with Non-Obstructive Azoospermia: Do They Really Proliferate?." Life 11, br. 11 (2021). https://doi.org/10.3390/life11111266

Hauptman, D., et al. (2021) 'Leydig Cells in Patients with Non-Obstructive Azoospermia: Do They Really Proliferate?', Life, 11(11). doi: 10.3390/life11111266

Hauptman D, Himelreich Perić M, Marić T, Katušić Bojanac A, Sinčić N, Zimak Z, i sur.. Leydig Cells in Patients with Non-Obstructive Azoospermia: Do They Really Proliferate?. Life [Internet]. 19.11.2021. [pristupljeno 09.11.2024.];11(11). doi: 10.3390/life11111266

D. Hauptman, et al., "Leydig Cells in Patients with Non-Obstructive Azoospermia: Do They Really Proliferate?", Life, vol. 11, br. 11, Studeni 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:510919. [Citirano: 09.11.2024.]

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Podaci o radu
Naslov (engleski)Leydig Cells in Patients with Non-Obstructive Azoospermia: Do They Really Proliferate?
AutorDinko Hauptman
AutorMarta Himelreich Perić
AutorTihana Marić
AutorAna Katušić Bojanac
AutorNino Sinčić
AutorZoran Zimak
AutorŽeljko Kaštelan
AutorDavor Ježek
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA HISTOLOGIJU I EMBRIOLOGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA MEDICINSKU BIOLOGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA UROLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Citologija, histologija i embriologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Urologija
Sažetak (engleski)
Background: Non-obstructive azoospermia (NOA) is a form of male infertility caused by disorders of the testicular parenchyma and impaired spermatogenesis. This study aimed to investigate the nature of Leydig cell changes in patients with NOA, especially whether their actual proliferation occurred. ----- Methods: 48 testicular biopsies from infertile patients with NOA and 24 testicular biopsies originating from azoospermic patients suffering from obstructive azoospermia (OA) were included in the study. Leydig cells and their possible proliferative activity were analysed by immunohistochemistry and morphometry (stereology). ----- Results: Unlike in the OA group, Leydig cells in NOA patients were sometimes organised into larger clusters and displayed an abundant cytoplasm/hypertrophy. Moreover, significant fibrosis of the interstitial compartment was demonstrated in some NOA samples, often accompanied by inflammatory cells. Stereological analysis showed no increase/proliferation of Leydig cells; on the contrary, these cells decreased in number in the NOA group. ----- Conclusions: The decrease in the number of Leydig cells can be explained by previous inflammatory changes within the testicular interstitium and consequent interstitial fibrosis. The interstitial fibrosis might have a deteriorating effect on Leydig cells.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaLife
Brojčani podacivol. 11, br. 11, 1266
e-ISSN2075-1729
DOIhttps://doi.org/10.3390/life11111266
URN:NBNurn:nbn:hr:105:510919
Datum objave publikacije2021-11-19
URL dokumentahttps://www.mdpi.com/2075-1729/11/11/1266
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-03-01 09:39:05