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Identification of Recent Tuberculosis Exposure Using QuantiFERON-TB Gold Plus, a Multicenter Study
Microbiology Spectrum, 9 (2021), 3; e0097221.. https://doi.org/10.1128/Spectrum.00972-21
(ESCMID Study Group for Mycobacterial Infections (ESGMYC), Mycobacteria Study Group (GEIM) of the Spanish Society of Clinical Microbiology and Infectious Diseases (SEIMC)) Pérez-Recio, Sandra; Pallarès, Natàlia; Grijota-Camino, Maria D.; Sánchez-Montalvá, Adrián; Barcia, Laura; Campos-Gutiérrez, Silvia; Pomar, Virginia; Rabuñal-Rey, Ramón; Balcells, María Elvira; Gazel, Deniz; Montiel, Natalia; Vicente, Diego; Goić-Barišić, Ivana; Schön, Thomas; Paues, Jakob; Mareković, Ivana; Cacho-Calvo, Juana; Barac, Aleksandra; Goletti, Delia; García-Gasalla, Mercedes; Barcala, José María; Tórtola, María Teresa; Anibarro, Luis; Suárez-Toste, Isabel; Moga, Esther; Gude-Gonzalez, María J.; Naves, Rodrigo; Karslıgil, Tekin; Martin-Peñaranda, Tania; Stevanovic, Goran; Trigo, Matilde; Rubio, Verónica; Karaoğlan, İlkay; Bayram, Nazan; Alcaide, Fernando; Tebé, Cristian; Santin, Miguel Više autora...

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Pérez Recio, S., Pallarès, N., Grijota Camino, M. D., Sánchez Montalvá, A., Barcia, L., Campos Gutiérrez, S. ... Santin, M. (2021). Identification of Recent Tuberculosis Exposure Using QuantiFERON-TB Gold Plus, a Multicenter Study. Microbiology Spectrum, 9. (3). doi: 10.1128/Spectrum.00972-21

Pérez Recio, Sandra, et al. "Identification of Recent Tuberculosis Exposure Using QuantiFERON-TB Gold Plus, a Multicenter Study." Microbiology Spectrum, vol. 9, br. 3, 2021. https://doi.org/10.1128/Spectrum.00972-21

Pérez Recio, Sandra, Natàlia Pallarès, Maria D. Grijota Camino, Adrián Sánchez Montalvá, Laura Barcia, Silvia Campos Gutiérrez, Virginia Pomar, et al. "Identification of Recent Tuberculosis Exposure Using QuantiFERON-TB Gold Plus, a Multicenter Study." Microbiology Spectrum 9, br. 3 (2021). https://doi.org/10.1128/Spectrum.00972-21

Pérez Recio, S., et al. (2021) 'Identification of Recent Tuberculosis Exposure Using QuantiFERON-TB Gold Plus, a Multicenter Study', Microbiology Spectrum, 9(3). doi: 10.1128/Spectrum.00972-21

Pérez Recio S, Pallarès N, Grijota Camino MD, Sánchez Montalvá A, Barcia L, Campos Gutiérrez S, i sur.. Identification of Recent Tuberculosis Exposure Using QuantiFERON-TB Gold Plus, a Multicenter Study. Microbiology Spectrum [Internet]. 22.12.2021. [pristupljeno 01.05.2024.];9(3). doi: 10.1128/Spectrum.00972-21

S. Pérez Recio, et al., "Identification of Recent Tuberculosis Exposure Using QuantiFERON-TB Gold Plus, a Multicenter Study", Microbiology Spectrum, vol. 9, br. 3, Prosinac 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:700919. [Citirano: 01.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:700919
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Naslov (engleski)Identification of Recent Tuberculosis Exposure Using QuantiFERON-TB Gold Plus, a Multicenter Study
AutorSandra Pérez-Recio
AutorNatàlia Pallarès
AutorMaria D. Grijota-Camino
AutorAdrián Sánchez-Montalvá
AutorLaura Barcia
AutorSilvia Campos-Gutiérrez
AutorVirginia Pomar
AutorRamón Rabuñal-Rey
AutorMaría Elvira Balcells
AutorDeniz Gazel
AutorNatalia Montiel
AutorDiego Vicente
AutorIvana Goić-Barišić
AutorThomas Schön
AutorJakob Paues
AutorIvana Mareković
AutorJuana Cacho-Calvo
AutorAleksandra Barac
AutorDelia Goletti
AutorMercedes García-Gasalla
AutorJosé María Barcala
AutorMaría Teresa Tórtola
AutorLuis Anibarro
AutorIsabel Suárez-Toste
AutorEsther Moga
AutorMaría J. Gude-Gonzalez
AutorRodrigo Naves
AutorTekin Karslıgil
AutorTania Martin-Peñaranda
AutorGoran Stevanovic
AutorMatilde Trigo
AutorVerónica Rubio
Autorİlkay Karaoğlan
AutorNazan Bayram
AutorFernando Alcaide
AutorCristian Tebé
AutorMiguel Santin
KolaboracijaESCMID Study Group for Mycobacterial Infections (ESGMYC)
KolaboracijaMycobacteria Study Group (GEIM) of the Spanish Society of Clinical Microbiology and Infectious Diseases (SEIMC)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA MEDICINSKU MIKROBIOLOGIJU I PARAZITOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Medicinska mikrobiologija
Sažetak (engleski)
We investigated whether the difference of antigen tube 2 (TB2) minus antigen tube 1 (TB1) (TB2-TB1) of the QuantiFERON-TB gold plus test, which has been postulated as a surrogate for the CD8+ T-cell response, could be useful in identifying recent tuberculosis (TB) exposure. We looked at the interferon gamma (IFN-γ) responses and differences in TB2 and TB1 tubes for 686 adults with QFT-plus positive test results. These results were compared among groups with high (368 TB contacts), low (229 patients with immune-mediated inflammatory diseases [IMID]), and indeterminate (89 asylum seekers or people from abroad [ASPFA]) risks of recent TB exposure. A TB2-TB1 value >0.6 IU·ml-1 was deemed to indicate a true difference between tubes. In the whole cohort, 13.6%, 10.9%, and 11.2% of cases had a TB2>TB1 result in the contact, IMID, and ASPFA groups, respectively (P = 0.591). The adjusted odds ratios (aORs) for an association between a TB2-TB1 result of >0.6 IU·ml-1 and risk of recent exposure versus contacts were 0.71 (95% confidence interval [CI], 0.31 to 1.61) for the IMID group and 0.86 (95% CI, 0.49 to 1.52) for the ASPFA group. In TB contact subgroups, 11.4%, 15.4%, and 17.7% with close, frequent, and sporadic contact had a TB2>TB1 result (P = 0.362). The aORs versus the close subgroup were 1.29 (95% CI, 0.63 to 2.62) for the frequent subgroup and 1.55 (95% CI, 0.67 to 3.60) for the sporadic subgroup. A TB2-TB1 difference of >0.6 IU·ml-1 was not associated with increased risk of recent TB exposure, which puts into question the clinical potential as a proxy marker for recently acquired TB infection. IMPORTANCE Contact tuberculosis tracing is essential to identify recently infected people, who therefore merit preventive treatment. However, there are no diagnostic tests that can determine whether the infection is a result of a recent exposure or not. It has been suggested that by using the QuantiFERON-TB gold plus, an interferon gamma (IFN-γ) release assay, a difference in IFN-γ production between the two antigen tubes (TB2 minus TB1) of >0.6 IU·ml-1 could serve as a proxy marker for recent infection. In this large multinational study, infected individuals could not be classified according to the risk of recent exposure based on differences in IFN-γ in TB1 and TB2 tubes that were higher than 0.6 IU·ml-1. QuantiFERON-TB gold plus is not able to distinguish between recent and remotely acquired tuberculosis infection, and it should not be used for that purpose in contact tuberculosis tracing.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaMicrobiology Spectrum
Brojčani podacivol. 9, br. 3, e0097221.
e-ISSN2165-0497
DOIhttps://doi.org/10.1128/Spectrum.00972-21
URN:NBNurn:nbn:hr:105:700919
Datum objave publikacije2021-12-22
URL dokumentahttps://journals.asm.org/doi/10.1128/Spectrum.00972-21
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-03-14 08:45:25