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S-GRAS score for prognostic classification of adrenocortical carcinoma: an international, multicenter ENSAT study
European Journal of Endocrinology, 186 (2021), 1; 25-36. https://doi.org/10.1530/EJE-21-0510
Elhassan, Y S; Altieri, B; Berhane, S; Cosentini, D; Calabrese, A; Haissaguerre, M; Kaštelan, Darko; Fragoso, M C B V; Bertherat, J; Al Ghuzlan, A; Haak, H; Boudina, M; Canu, L; Loli, P; Sherlock, M; Kimpel, O; Laganà, M; Sitch, A J; Kroiss, M; Arlt, W; Terzolo, M; Berruti, A; Deeks, J J; Libé, R; Fassnacht, M; Ronchi, C L Više autora...

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Elhassan, Y. S., Altieri, B., Berhane, S., Cosentini, D., Calabrese, A., Haissaguerre, M. ... Ronchi, C. L. (2021). S-GRAS score for prognostic classification of adrenocortical carcinoma: an international, multicenter ENSAT study. European Journal of Endocrinology, 186. (1), 25-36. doi: 10.1530/EJE-21-0510

Elhassan, Y S, et al. "S-GRAS score for prognostic classification of adrenocortical carcinoma: an international, multicenter ENSAT study." European Journal of Endocrinology, vol. 186, br. 1, 2021, str. 25-36. https://doi.org/10.1530/EJE-21-0510

Elhassan, Y S, B Altieri, S Berhane, D Cosentini, A Calabrese, M Haissaguerre, Darko Kaštelan, et al. "S-GRAS score for prognostic classification of adrenocortical carcinoma: an international, multicenter ENSAT study." European Journal of Endocrinology 186, br. 1 (2021): 25-36. https://doi.org/10.1530/EJE-21-0510

Elhassan, Y. S., et al. (2021) 'S-GRAS score for prognostic classification of adrenocortical carcinoma: an international, multicenter ENSAT study', European Journal of Endocrinology, 186(1), str. 25-36. doi: 10.1530/EJE-21-0510

Elhassan YS, Altieri B, Berhane S, Cosentini D, Calabrese A, Haissaguerre M, i sur.. S-GRAS score for prognostic classification of adrenocortical carcinoma: an international, multicenter ENSAT study. European Journal of Endocrinology [Internet]. 30.11.2021. [pristupljeno 12.04.2024.];186(1):25-36. doi: 10.1530/EJE-21-0510

Y. S. Elhassan, et al., "S-GRAS score for prognostic classification of adrenocortical carcinoma: an international, multicenter ENSAT study", European Journal of Endocrinology, vol. 186, br. 1, str. 25-36, Studeni 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:228456. [Citirano: 12.04.2024.]

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Naslov (engleski)S-GRAS score for prognostic classification of adrenocortical carcinoma: an international, multicenter ENSAT study
AutorY S Elhassan
AutorB Altieri
AutorS Berhane
AutorD Cosentini
AutorA Calabrese
AutorM Haissaguerre
AutorDarko Kaštelan
AutorM C B V Fragoso
AutorJ Bertherat
AutorA Al Ghuzlan
AutorH Haak
AutorM Boudina
AutorL Canu
AutorP Loli
AutorM Sherlock
AutorO Kimpel
AutorM Laganà
AutorA J Sitch
AutorM Kroiss
AutorW Arlt
AutorM Terzolo
AutorA Berruti
AutorJ J Deeks
AutorR Libé
AutorM Fassnacht
AutorC L Ronchi
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Objective: Adrenocortical carcinoma (ACC) has an aggressive but variable clinical course. Prognostic stratification based on the European Network for the Study of Adrenal Tumours stage and Ki67 index is limited. We aimed to demonstrate the prognostic role of a points-based score (S-GRAS) in a large cohort of patients with ACC. ----- Design: This is a multicentre, retrospective study on ACC patients who underwent adrenalectomy. ----- Methods: The S-GRAS score was calculated as a sum of the following points: tumour stage (1-2 = 0; 3 = 1; 4 = 2), grade (Ki67 index 0-9% = 0; 10-19% = 1; ≥20% = 2 points), resection status (R0 = 0; RX = 1; R1 = 2; R2 = 3), age (<50 years = 0; ≥50 years = 1), symptoms (no = 0; yes = 1), and categorised, generating four groups (0-1, 2-3, 4-5, and 6-9). Endpoints were progression-free survival (PFS) and disease-specific survival (DSS). The discriminative performance of S-GRAS and its components was tested by Harrell's Concordance index (C-index) and Royston-Sauerbrei's R2D statistic. ----- Results: We included 942 ACC patients. The S-GRAS score showed superior prognostic performance for both PFS and DSS, with best discrimination obtained using the individual scores (0-9) (C-index = 0.73, R2D = 0.30, and C-index = 0.79, R2D = 0.45, respectively, all P < 0.01vs each component). The superiority of S-GRAS score remained when comparing patients treated or not with adjuvant mitotane (n = 481 vs 314). In particular, the risk of recurrence was significantly reduced as a result of adjuvant mitotane only in patients with S-GRAS 4-5. ----- Conclusion: The prognostic performance of S-GRAS is superior to tumour stage and Ki67 in operated ACC patients, independently from adjuvant mitotane. S-GRAS score provides a new important guide for personalised management of ACC (i.e. radiological surveillance and adjuvant treatment).
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaEuropean Journal of Endocrinology
Brojčani podacivol. 186, br. 1, str. 25-36
p-ISSN0804-4643
e-ISSN1479-683X
DOIhttps://doi.org/10.1530/EJE-21-0510
URN:NBNurn:nbn:hr:105:228456
Datum objave publikacije2021-11-30
URL dokumentahttps://eje.bioscientifica.com/view/journals/eje/186/1/EJE-21-0510.xml
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-04-01 08:08:53