prikaz prve stranice dokumenta Robert’s Intragastric Alcohol-Induced Gastric Lesion Model as an Escalated General Peripheral and Central Syndrome, Counteracted by the Stable Gastric Pentadecapeptide BPC 157
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Robert’s Intragastric Alcohol-Induced Gastric Lesion Model as an Escalated General Peripheral and Central Syndrome, Counteracted by the Stable Gastric Pentadecapeptide BPC 157
Biomedicines, 9 (2021), 10; 1300. https://doi.org/10.3390/biomedicines9101300
Gojković, Slaven; Krezić, Ivan; Vraneš, Hrvoje; Žižek, Helena; Drmić, Domagoj; Batelja Vuletić, Lovorka; Milavić, Marija; Sikirić, Sunčana; Stilinović, Irma; Simeon, Paris; Knežević, Mario; Kolak, Toni; Tepeš, Marijan; Simonji, Karol; Štrbe, Sanja; Nikolac Gabaj, Nora; Barišić, Ivan; Orešković, Emma Grace; Lovrić, Eva; Kokot, Antonio; Škrtić, Anita; Boban Blagaić, Alenka; Seiwerth, Sven; Sikirić, Predrag Više autora...

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Gojković, S., Krezić, I., Vraneš, H., Žižek, H., Drmić, D., Batelja Vuletić, L. ... Sikirić, P. (2021). Robert’s Intragastric Alcohol-Induced Gastric Lesion Model as an Escalated General Peripheral and Central Syndrome, Counteracted by the Stable Gastric Pentadecapeptide BPC 157. Biomedicines, 9. (10). doi: 10.3390/biomedicines9101300

Gojković, Slaven, et al. "Robert’s Intragastric Alcohol-Induced Gastric Lesion Model as an Escalated General Peripheral and Central Syndrome, Counteracted by the Stable Gastric Pentadecapeptide BPC 157." Biomedicines, vol. 9, br. 10, 2021. https://doi.org/10.3390/biomedicines9101300

Gojković, Slaven, Ivan Krezić, Hrvoje Vraneš, Helena Žižek, Domagoj Drmić, Lovorka Batelja Vuletić, Marija Milavić, et al. "Robert’s Intragastric Alcohol-Induced Gastric Lesion Model as an Escalated General Peripheral and Central Syndrome, Counteracted by the Stable Gastric Pentadecapeptide BPC 157." Biomedicines 9, br. 10 (2021). https://doi.org/10.3390/biomedicines9101300

Gojković, S., et al. (2021) 'Robert’s Intragastric Alcohol-Induced Gastric Lesion Model as an Escalated General Peripheral and Central Syndrome, Counteracted by the Stable Gastric Pentadecapeptide BPC 157', Biomedicines, 9(10). doi: 10.3390/biomedicines9101300

Gojković S, Krezić I, Vraneš H, Žižek H, Drmić D, Batelja Vuletić L, i sur.. Robert’s Intragastric Alcohol-Induced Gastric Lesion Model as an Escalated General Peripheral and Central Syndrome, Counteracted by the Stable Gastric Pentadecapeptide BPC 157. Biomedicines [Internet]. 23.09.2021. [pristupljeno 15.03.2025.];9(10). doi: 10.3390/biomedicines9101300

S. Gojković, et al., "Robert’s Intragastric Alcohol-Induced Gastric Lesion Model as an Escalated General Peripheral and Central Syndrome, Counteracted by the Stable Gastric Pentadecapeptide BPC 157", Biomedicines, vol. 9, br. 10, Rujan 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:165684. [Citirano: 15.03.2025.]

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Podaci o radu
Naslov (engleski)Robert’s Intragastric Alcohol-Induced Gastric Lesion Model as an Escalated General Peripheral and Central Syndrome, Counteracted by the Stable Gastric Pentadecapeptide BPC 157
AutorSlaven Gojković
AutorIvan Krezić
AutorHrvoje Vraneš
AutorHelena Žižek
AutorDomagoj Drmić
AutorLovorka Batelja Vuletić
AutorMarija Milavić
AutorSunčana Sikirić
AutorIrma Stilinović
AutorParis Simeon
AutorMario Knežević
AutorToni Kolak
AutorMarijan Tepeš
AutorKarol Simonji
AutorSanja Štrbe
MBZ: 319335
AutorNora Nikolac Gabaj
AutorIvan Barišić
AutorEmma Grace Orešković
AutorEva Lovrić
AutorAntonio Kokot
AutorAnita Škrtić
AutorAlenka Boban Blagaić
AutorSven Seiwerth
AutorPredrag Sikirić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA TEMELJNU I KLINIČKU FARMAKOLOGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PATOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Patologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Farmakologija
Sažetak (engleski)
We redefined Robert’s prototypical cytoprotection model, namely the intragastric administration of 96% alcohol in order to generate a general peripheral and central syndrome similar to that which occurs when major central or peripheral veins are occluded in animal models. With this redefinition, we used Robert’s model to examine the cytoprotective effects of the stable gastric pentadecapeptide BPC 157. The intragastric administration of alcohol induced gastric lesions, intracranial (superior... Više sagittal sinus) hypertension, severe brain swelling and lesions, portal and vena caval hypertension, aortal hypotension, severe thrombosis, inferior vena cava and superior mesenteric vein congestion, azygos vein failure (as a failed collateral pathway), electrocardiogram disturbances, and heart, lung, liver and kidney lesions. The use of BPC 157 therapy (10 µg/kg or 10 ng/kg given intraperitoneally 1 min after alcohol) counteracted these deficits rapidly. Specifically, BPC 157 reversed brain swelling and superior mesenteric vein and inferior vena caval congestion, and helped the azygos vein to recover, which improved the collateral blood flow pathway. Microscopically, BPC 157 counteracted brain (i.e., intracerebral hemorrhage with degenerative changes of cerebral and cerebellar neurons), heart (acute subendocardial infarct), lung (parenchymal hemorrhage), liver (congestion), kidney (congestion) and gastrointestinal (epithelium loss, hemorrhagic gastritis) lesions. In addition, this may have taken place along with the activation of specific molecular pathways. In conclusion, these findings clarify and extend the theory of cytoprotection, offer an approach to its practical application, and establish BPC 157 as a prospective cytoprotective treatment. Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiomedicines
Brojčani podacivol. 9, br. 10, 1300
e-ISSN2227-9059
DOIhttps://doi.org/10.3390/biomedicines9101300
URN:NBNurn:nbn:hr:105:165684
Datum objave publikacije2021-09-23
URL dokumentahttps://www.mdpi.com/2227-9059/9/10/1300
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-04-01 11:35:48
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